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Condition: Diabetes Mellitus

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Total 6126 results found since Jan 2013.

CYP2C19 Loss-of-Function Variants Associated with Long-term Ischemic Stroke Events During Clopidogrel Treatment in the Chinese Population
This study aims to determine whether CYP2C19 loss-of-function (LoF) variants were associated with long-term ischemic stroke risk in Chinese primary care patients treated with clopidogrel. Patients treated with clopidogrel were ascertained from a Chinese Electronic Medical Record linked with biobank for a retrospective cohort study. Their medical information was examined for the period from January 2018 to December 2021. Two CYP2C19 major loss of function variants (*2:rs4244285, *3: rs4986893) were genotyped. The clinical outcome was ischemic stroke event. Cox regression analysis was used to evaluate the association between...
Source: Clinical Pharmacology and Therapeutics - August 22, 2023 Category: Drugs & Pharmacology Authors: Peng Wu Ziqing Liu Zijian Tian Benrui Wu Jian Shao Qian Li Zhaoxu Geng Ying Pan Ke Lu Qiang Wang Tao Xu Kaixin Zhou Source Type: research

Consensus statement for the management of incidentally found brain white matter hyperintensities in general medical practice
Med J Aust. 2023 Aug 21. doi: 10.5694/mja2.52079. Online ahead of print.ABSTRACTINTRODUCTION: There is a paradigm shift in our understanding of white matter hyperintensities (WMH) found on brain imaging. They were once thought to be a normal phenomenon of ageing and, therefore, warranted no further investigation. However, evidence now suggests these lesions are markers of poor brain and cardiovascular health, portending an increased risk of stroke, cognitive decline, depression and death. Nevertheless, no specific guidelines exist for the management of incidentally found WMH for general medical practitioners and other clin...
Source: Med J Aust - August 21, 2023 Category: General Medicine Authors: Thomas P Ottavi Elizabeth Pepper Grant Bateman Mark Fiorentino Amy Brodtmann Source Type: research

P114/135 Drug-coated balloons for treatment of in-stent restenosis following carotid artery stenting: a major case, single center study
ConclusionIn our practice, DCB offers a straightforward option to treat restenosis of the ACI ostium. The low rate of periprocedural complications and the median time of freedom from symptoms and/or restenosis suggest that DCB angioplasty for ISRS is a viable treatment.Disclosure of InterestNothing to disclose
Source: Journal of NeuroInterventional Surgery - August 21, 2023 Category: Neurosurgery Authors: Hajiyev, K., Gottberg, P. v., Henkes, H. Tags: 3.1 OTHER - Innovation Source Type: research

P175/308 Analysis of demographic, procedural and imaging data of patients with acute arteriosclerotic tandem lesion: Age and stroke severity matters most for clinical outcome
ConclusionEVT for TL is safe and effective. Lower age and shorter procedural time both correlate with successful outcomes, but the fact that stroke severity, neurological issues and diabetes are linked to higher mortality shows the connotation of comorbidities with long-term survival.Disclosure of InterestAll authors: Nothing to disclose
Source: Journal of NeuroInterventional Surgery - August 21, 2023 Category: Neurosurgery Authors: Huber, C., Gruber, P., Berberat, J., Sassenburg, R., Pflugi, S., Anon, J., Diepers, M., Andereggen, L., Kahles, T., Nedeltchev, K., Remonda, L. Tags: 2.3 ISCHEMIC - Treatment Source Type: research

Quantifying the potential effects of air pollution reduction on population health and health expenditure in Taiwan
Environ Pollut. 2023 Aug 17:122405. doi: 10.1016/j.envpol.2023.122405. Online ahead of print.ABSTRACTAir pollution, particularly ambient fine particulate matter (PM2.5) pollution, poses a significant risk to public health, underscoring the importance of comprehending the long-term impact on health burden and expenditure at national and subnational levels. Therefore, this study aims to quantify the disease burden and healthcare expenditure associated with PM2.5 exposure in Taiwan and assess the potential benefits of reducing pollution levels. Using a comparative risk assessment framework that integrates an auto-aggressive i...
Source: Environmental Pollution - August 19, 2023 Category: Environmental Health Authors: Yi-Hsuan Roger Chen Wan-Chen Lee Bo-Chen Liu Po-Chieh Yang Chi-Chang Ho Jing-Shiang Hwang Tzu-Hsuan Huang Hsien-Ho Lin Wei-Cheng Lo Source Type: research

Chronic comorbid conditions and asthma exacerbation occurrence in a general population sample
In conclusion, several chronic comorbid conditions were associated with asthma exacerbation occurrence, which confirms but also complements previous studies. Our observations contribute to understanding exacerbation risk estimation and, ultimately, personalized asthma management.PMID:37567896 | DOI:10.1038/s41533-023-00350-x
Source: Primary Care - August 11, 2023 Category: Primary Care Authors: Emma Baljet Hilde Luijks Lisette van den Bemt Tjard R Schermer Source Type: research

Role of GLP-1 receptor agonist in diabetic cardio-renal disorder: Recent updates of clinical and pre-clinical evidence
Curr Diabetes Rev. 2023 Aug 9. doi: 10.2174/1573399820666230809152148. Online ahead of print.ABSTRACTCardiovascular complications and renal disease is the growing cause of mortality in patients with diabetes. The subversive complications of diabetes such as hyperglycemia, hyperlipidemia and insulin resistance lead to an increase in the risk of myocardial infarction (MI), stroke, heart failure (HF) as well as chronic kidney disease (CKD). Among the commercially available anti-hyperglycemic agents, incretin-based medications appear to be safe and effective in the treatment of type 2 diabetes mellitus (T2DM) and associated ca...
Source: Current Diabetes Reviews - August 10, 2023 Category: Endocrinology Authors: Sanket Seksaria Bhaskar Jyoti Dutta Mandeep Kaur Ghanshyam Das Gupta Surendra H Bodakhe Amrita Singh Source Type: research

Iran Quality of Care in Medicine Program (IQCAMP): Design and Outcomes
CONCLUSION: The IQCAMP study was the first healthcare utilization, cost, and quality survey in Iran with a longitudinal data collection to represent the pattern, quantity, and quality of medical care provided for high-burden conditions.PMID:37543935 | DOI:10.34172/aim.2023.21
Source: Archives of Iranian Medicine - August 6, 2023 Category: Middle East Health Authors: Saeid Shahraz Sarvenaz Shahin Yosef Farzi Mitra Modirian Nazila Shahbal Mehrdad Azmin Farnam Mohebi Mohammadreza Naderian Masoume Amin-Esmaeili Naser Ahmadi Shahedeh Seyfi Hossein Zokaei Roya Samadi Bahram Mohajer Roya Sherafat-Kazemzadeh Abbas Balouchi B Source Type: research