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Effects and outcomes of cardiac surgery in patients with cardiometabolic syndrome
ConclusionsPatients with CMS were more likely to present with increased comorbidities. Patients with CMS undergoing CABG were at risk for worse short ‐term secondary postoperative outcomes and reduced long‐term survival. The data supports the need for further investigation for risk reduction surrounding operative revascularization.
Source: Journal of Cardiac Surgery - February 17, 2020 Category: Cardiovascular & Thoracic Surgery Authors: David Zapata, Michael Halkos, Jose Binongo, John Puskas, Robert Guyton, Omar Lattouf Tags: ORIGINAL ARTICLE Source Type: research

Atrial myxoma with cerebellar signs: a case report
ConclusionAlthough rare, atrial myxoma has to be considered a cause of stroke and other embolic phenomenon causing multiorgan infarctions. Early and timely diagnosis of the condition can prevent further recurrence and inappropriate anticoagulant therapy. It would be pertinent to have echocardiography done in patients who present with a stroke, arrhythmias, and other constitutional symptoms. The tumor once detected must be removed surgically as early as possible, which not only reduces serious thromboembolic complications but can be potentially curative.
Source: Journal of Medical Case Reports - February 13, 2020 Category: General Medicine Source Type: research

Good oral hygiene isn’t just for the mouth: It benefits brain health too
(Natural News) Heart disease and cerebrovascular diseases (e.g., stroke) are the leading causes of death in western countries. These diseases are caused by several factors, such as hypertension, high blood cholesterol, diabetes mellitus, smoking and obesity. However, recent studies have found that there is another unexpected contributor to the development of atherosclerosis and atherothrombosis (blood clot...
Source: NaturalNews.com - February 12, 2020 Category: Consumer Health News Source Type: news

Predicting the Risk of Ischemic Stroke among Patients with Rheumatoid Arthritis Using a Simplified RA-CHADSV Score Based on the CHA2DS2-VASc Score.
CONCLUSIONS: A simplified RA-CHADSV score, with comparable efficiency as the CHA2DS2-VASc score, but easier to use clinically was developed for predicting the risk of ischemic stroke among non-AF RA patients. PMID: 32059458 [PubMed - in process]
Source: Medicina (Kaunas) - February 12, 2020 Category: Universities & Medical Training Authors: Hsu CW, Ng KJ, Lu MC, Koo M Tags: Medicina (Kaunas) Source Type: research

Current Use and Trends in Unprotected Left Main Coronary Artery Percutaneous Intervention
AbstractPurpose of ReviewTo review the clinical evidence on the use of percutaneous coronary intervention (PCI) revascularization options in left main (LM) disease in comparison with coronary artery bypass graft (CABG). Coronary artery disease (CAD) involving the LM is associated with high morbidity and mortality. Though CABG remains the gold standard for complex CAD involving the LM artery, recent trials have shown a trend towards non-inferiority of the LM PCI when compared with CABG in certain subset of patients.Recent FindingsTwo recent major randomized trials compared the outcomes of PCI versus CABG in the LM and multi...
Source: Current Cardiology Reports - February 8, 2020 Category: Cardiology Source Type: research

Development of a Cardiovascular Disease Risk Prediction Model Using the Suita Study, a Population-Based Prospective Cohort Study in Japan.
CONCLUSIONS: The Suita CVD risk model is feasible to use and improves predictability of the incidence of CVD relative to the FRS model in Japan. PMID: 32023562 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - February 7, 2020 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Effect of inter-arm blood pressure differences on outcomes after percutaneous coronary intervention.
CONCLUSION: Among patients treated with PCI, the incidence of MACE was significantly higher in those with a higher IABPD (≥10 mmHg) than in those with a lower IABPD (<10 mmHg), which was mainly driven by ischemia-driven target vessel revascularization. PMID: 32037252 [PubMed - as supplied by publisher]
Source: Journal of Cardiology - February 6, 2020 Category: Cardiology Authors: Park SJ, Son JW, Hong KS, Choi HH Tags: J Cardiol Source Type: research

Relationship of White Matter Lesions with Intracerebral Hemorrhage Expansion and Functional Outcome: MISTIE II and CLEAR III
ConclusionsConcomitant WML does not increase the odds for HE in patients with ICH but increases the odds for poor functional outcome.Clinical Trial Registrationhttp://www.clinicaltrials.gov trial-identifiers: NCT00224770 and NCT00784134.
Source: Neurocritical Care - February 5, 2020 Category: Neurology Source Type: research

Skipping breakfast before and during early pregnancy and incidence of gestational diabetes mellitus: the Japan Environment and Children's Study.
CONCLUSIONS: Breakfast consumption <3 times/wk before and during early pregnancy, compared with daily consumption, was associated with an increased odds of developing GDM. PMID: 32020171 [PubMed - as supplied by publisher]
Source: The American Journal of Clinical Nutrition - February 5, 2020 Category: Nutrition Authors: Dong JY, Ikehara S, Kimura T, Cui M, Kawanishi Y, Kimura T, Ueda K, Iso H, Japan Environment and Children's Study Group Tags: Am J Clin Nutr Source Type: research

Antihypertensive Effectiveness of Perindopril Arginine and Indapamide Single-Pill Combination According to Body Mass Index: Findings from the FORSAGE Study
ConclusionsIn subjects with uncontrolled BP on existing antihypertensive therapy, switching to perindopril arginine 10  mg/indapamide 2.5 mg was associated with statistically significant decreases in BP and higher rates of target BP achievement in all BMI groups, including more than 70% of overweight and obese patients.Trial RegistrationISRCTN ID, ISRCTN14315146 (retrospectively registered 18/11/2019).
Source: Cardiology and Therapy - February 1, 2020 Category: Cardiology Source Type: research

Efficacy and safety of edoxaban in patients with diabetes mellitus in the ENGAGE AF-TIMI 48 trial
Diabetes mellitus is an independent risk factor for stroke and atrial fibrillation. Therefore, the risk/benefit profile of the oral factor Xa inhibitor edoxaban stratified by diabetes is of clinical interest.
Source: International Journal of Cardiology - January 30, 2020 Category: Cardiology Authors: Anna Plitt, Christian T. Ruff, Assen Goudev, Joao Morais, Miodrag C. Ostojic, Michael A. Grosso, Hans J. Lanz, Jeong-Gun Park, Elliott M. Antman, Eugene Braunwald, Robert P. Giugliano Source Type: research

Effect of Dapagliflozin on Atrial Fibrillation in Patients with Type 2 Diabetes Mellitus: Insights from the DECLARE-TIMI 58 Trial.
Conclusions: Dapagliflozin decreased the incidence of reported episodes of AF/AFL adverse events in high-risk patients with T2DM. This effect was consistent regardless of the patients' prior history of AF, ASCVD, or HF. Clinical Trial Registration: URL: https://clinicaltrials.gov Unique Identifier: NCT01730534. PMID: 31983236 [PubMed - as supplied by publisher]
Source: Circulation - January 27, 2020 Category: Cardiology Authors: Zelniker TA, Bonaca MP, Furtado R, Mosenzon O, Kuder JF, Murphy SA, Bhatt DL, Leiter LA, McGuire DK, Wilding JPH, Budaj A, Kiss RG, Padilla F, Gause-Nilsson I, Langkilde AM, Raz I, Sabatine MS, Wiviott SD Tags: Circulation Source Type: research

Advancing mediation analysis in occupational health research
In recent years, mediation analysis has become a popular means to identify and quantify pathways linking an exposure to an outcome, thereby elucidating how a particular exposure contributes to the occurrence of a specific outcome. When a mediator is a modifiable risk factor, this opens up new opportunities for interventions to block (part) of the exposure`s effect on the outcome. Recent examples in Scandinavian Journal of Work Environment Health have addressed the mediating effect of wellbeing on the association between type of office and job satisfaction (1) and examined whether workplace social capital contributes to the...
Source: Scandinavian Journal of Work, Environment and Health - January 17, 2020 Category: Occupational Health Tags: Editorial Source Type: research

Spectrum of Eye Disease in Diabetes (SPEED) in India: A prospective facility-based study. Report # 3. Retinal vascular occlusion in patients with type 2 diabetes mellitus
Conclusion: RVO is a frequent finding in people with T2DM. History of stroke carries the highest risk followed by HTN. The management of people with T2DM and RVO must also include comanagement of all associated systemic conditions.
Source: Indian Journal of Ophthalmology - January 17, 2020 Category: Opthalmology Authors: Harsha Bhattacharjee Manabjyoti Barman Divakant Misra Prabhjot K Multani Shriya Dhar Umesh C Behera Taraprasad Das Clare Gilbert G V S Murthy R Rajalakshmi Hira B Pant on behalf of the SPEED study group Source Type: research

Disseminated cutaneous herpes zoster and multiple cerebral infarcts in an adult with diabetes mellitus
We present the case of a patient with a medical history of type 2 diabetes mellitus (DM) who experienced disseminated cutaneous VZV infection followed by multiple cerebral infarcts associated with VZV vasculopathy. Brain magnetic resonance imaging revealed multiple hyperintense lesions over the bilateral deep white matter and basal ganglia. A skin biopsy revealed small-vessel leukocytoclastic vasculitis with neutrophilic, lymphocytic, and eosinophilic infiltration. This case report describes the rare finding of cutaneous leukocytoclastic vasculitis in VZV infection and highlights that VZV infection is an uncommon but criti...
Source: Journal of NeuroVirology - January 15, 2020 Category: Neurology Source Type: research

The role of diabetes mellitus on the thrombus composition in patients with acute ischemic stroke.
CONCLUSION: Clots in diabetic patients had more fibrin and fewer erythrocyte components compared with patients without diabetes mellitus, while hyperglycemia on admission did not show association with clot composition. Further studies are needed to confirm these results. PMID: 31924102 [PubMed - as supplied by publisher]
Source: Interventional Neuroradiology - January 13, 2020 Category: Radiology Tags: Interv Neuroradiol Source Type: research

Porcine models for studying complications and organ crosstalk in diabetes mellitus
This article provides an overview of concepts for the development of porcine models for diabetes and obesity research, with a focus on genetically engineered models. Diabetes-associated ocular, cardiovascular and renal alterations observed in diabetic pig models are summarized and their similarities with complications in diabetic patients are discussed. Systematic multi-organ biobanking of porcine models of diabetes and obesity and molecular profiling of representative tissue samples on different levels, e.g., on the transcriptome, proteome, or metabolome level, is proposed as a strategy for discovering tissue-specific pat...
Source: Cell and Tissue Research - January 13, 2020 Category: Cytology Source Type: research

Effects of Diabetes Mellitus on Functional Outcomes and Complications After Torsional Ankle Fracture.
CONCLUSIONS: Diabetes was associated with more complications and secondary operations. However, functional outcomes including pain and dysfunction were not markedly affected by these clinical outcomes, potentially due to diminished sensory function and less baseline physical activity among diabetic patients. LEVEL OF EVIDENCE: Prognostic level III. PMID: 31922995 [PubMed - as supplied by publisher]
Source: The Journal of the American Academy of Orthopaedic Surgeons - January 12, 2020 Category: Orthopaedics Tags: J Am Acad Orthop Surg Source Type: research

Costs associated with renal and cardiovascular events among patients with type 2 diabetes mellitus and nephropathy: a cost model based on the CREDENCE clinical trial.
Conclusions: Positive costs avoided for each of the outcomes considered were predicted in the main analysis, with ESKD as the outcome predicted to have the greatest costs avoided at $2.92 PMPY. PMID: 31916465 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - January 11, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Critical Differences Between Dietary Supplement and Prescription Omega-3 Fatty Acids: A Narrative Review
ConclusionConsumers and health care providers need to recognize critical differences between Rx and OM-3 dietary supplements to ensure appropriate use of each OM-3 product.
Source: Advances in Therapy - January 9, 2020 Category: Drugs & Pharmacology Source Type: research

Association Between Obesity Type and Common Vascular and Metabolic Diseases: A Cross-Sectional Study
Conclusions: Central obesity alone and compound obesity are associated with the risk of hypertension, hyperlipidemia, and diabetes mellitus. Compound obesity but not central obesity alone is associated with the risk of coronary heart disease, but further research is needed to confirm it. There are no significant relationship between stroke and central obesity alone or compound obesity.
Source: Frontiers in Endocrinology - January 9, 2020 Category: Endocrinology Source Type: research

Discriminative factors for post-stroke depression.
CONCLUSIONS: Rehabilitation experts working with patients with stroke should pay special attention to trunk control and basic activities of daily living for preventing consequences of PSD particularly in those with higher educational level and cardiac diseases. PMID: 31901586 [PubMed - as supplied by publisher]
Source: Asian Journal of Psychiatry - January 8, 2020 Category: Psychiatry Tags: Asian J Psychiatr Source Type: research

Pioglitazone and PPAR- γ modulating treatment in hypertensive and type 2 diabetic patients after ischemic stroke: a national cohort study
Peroxisome proliferator-activated receptor- γ (PPAR-γ) modulating treatment may have cardiovascular benefits in type 2 diabetes mellitus (T2DM) patients after ischemic stroke (IS). However, whether there are ad...
Source: Cardiovascular Diabetology - January 7, 2020 Category: Cardiology Authors: Chi-Hung Liu, Tsong-Hai Lee, Yu-Sheng Lin, Pi-Shan Sung, Yi-Chia Wei and Yan-Rong Li Tags: Original investigation Source Type: research

d-dimer and diffusion-weighted imaging pattern as two diagnostic indicators for cancer-related stroke: A case–control study based on the STROBE guidelines
The aim of this study was to evaluate the risk factors and elucidate the clinical characteristics of cancer-associated ischemic stroke to differentiate it from conventional ischemic stroke in China and East Asia. Between June 2012 and June 2016, a retrospective analysis was performed on 609 stroke patients with cancer. They were divided into 3 groups: cancer-stroke group (CSG, 203 cases), stroke group (SG, 203 cases), and cancer group (CG, 203 cases). The d-dimer levels and diffusion-weighted imaging lesion (DWI) pattern were compared to an age- and sex-matched control group. The most common cancer types were colorectal ca...
Source: Medicine - January 1, 2020 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Anaphylaxis-induced atrial fibrillation and anesthesia: Pathophysiologic and therapeutic considerations.
Abstract Atrial fibrillation is the most common cardiac arrhythmia in western society affecting more than 35 million individuals worldwide annually. It is a common postoperative complication and may also occur spontaneously during general and local anesthesia administration. Aging, diabetes mellitus, hypertension, and cardiovascular diseases including cardiomyopathies, congenital cardiac anomalies, heart failure, myocardial ischemia, pericarditis, previous cardiac surgery, vascular disease, and valvular heart disease are some correlated factors. Beyond age, increased incidence of atrial fibrillation has been corre...
Source: Annals of Cardiac Anaesthesia - January 1, 2020 Category: Anesthesiology Authors: Kounis NG, Koniari I, Tzanis G, Soufras GD, Velissaris D, Hahalis G Tags: Ann Card Anaesth Source Type: research

82-Year-Old Woman With Acute-Onset Left-Sided Weakness
An 82-year-old woman with a history of type 2 diabetes mellitus, hyperlipidemia, and hypertension presented to the emergency department with sudden onset of left arm and leg weakness. She was sitting in church when she developed left-sided posterior neck and shoulder pain, followed 1 hour later by sudden-onset dense left-sided weakness. Emergency medical services were called, and they activated the prehospital stroke-notification protocol. The patient arrived at the emergency department approximately 30 minutes after the onset of the weakness.
Source: Mayo Clinic Proceedings - January 1, 2020 Category: Internal Medicine Authors: Ronstan Lobo, Adam P. Sawatsky Tags: Residents ’ clinic Source Type: research

The association between CHA2DS2-VASc score and erectile dysfunction: a cross-sectional study
Conclusion: CHA2DS2-VASc score can be used to detect Erectile dysfunction in patients who are admitted to the cardiology outpatient clinics.
Source: International Braz J Urol - December 20, 2019 Category: Urology & Nephrology Source Type: research

Vitamin K Antagonist Use and Risk for Intracranial Carotid Artery Calcification in Patients With Intracerebral Hemorrhage
Conclusions: Our findings do not support VKA use as an independent risk factor for higher ICAC degree in patients with ICH. We could not confirm the concerns about VKA use and intracranial carotid vascular calcification. We suggest further research in other cohorts with VKA users such as patients with ischemic stroke and atrial fibrillation.
Source: Frontiers in Neurology - December 20, 2019 Category: Neurology Source Type: research

Nateglinide Exerts Neuroprotective Effects via Downregulation of HIF-1 α/TIM-3 Inflammatory Pathway and Promotion of Caveolin-1 Expression in the Rat’s Hippocampus Subjected to Focal Cerebral Ischemia/Reperfusion Injury
In conclusion, our work postulated that NAT exhibited its neuroprotective effects in rats with ischemic strokevia attenuation of different unique oxidative, apoptotic, and inflammatory pathways.
Source: Inflammation - December 20, 2019 Category: Allergy & Immunology Source Type: research

Heart Failure End Points in Cardiovascular Outcome Trials of Sodium Glucose Cotransporter 2 Inhibitors in Patients With Type 2 Diabetes Mellitus: A Critical Evaluation of Clinical and Regulatory Issues.
This report summarizes these discussions and the key takeaway messages from this meeting. PMID: 31841369 [PubMed - in process]
Source: Circulation - December 17, 2019 Category: Cardiology Authors: Butler J, Packer M, Greene SJ, Fiuzat M, Anker SD, Anstrom KJ, Carson PE, Cooper LB, Fonarow GC, Hernandez AF, Januzzi JL, Jessup M, Kalyani RR, Kaul S, Kosiborod M, Lindenfeld J, McGuire DK, Sabatine MS, Solomon SD, Teerlink JR, Vaduganathan M, Yancy CW, Tags: Circulation Source Type: research

A Post-Authorization Safety Study of Quetiapine as Antidepressant Treatment in Sweden: Nested Case –Control Analyses of Select Outcomes
ConclusionRisks for all-cause mortality, self-harm and suicide, and stroke in older patients may be higher among patients treated with quetiapine and antidepressant combination therapy.
Source: Drug Safety - December 17, 2019 Category: Drugs & Pharmacology Source Type: research

Myiasis in oral cavity: a report of 2 cases
Myiasis is a disease caused by the invasion of tissues by the larvae of flies. Herein, we present 2 cases of this disease. Case 1: a 47-year-old male patient with diabetes mellitus, hypertension, malnutrition, and mental disorders was hospitalized for sequelae of stroke. The intraoral examination revealed poor hygiene and the presence of an ulcerated lesion with a whitish border in the left upper lip mucosa showing larvae with wriggling movement. Case 2: an 11-year-old male patient diagnosed with cerebral palsy and West syndrome.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - December 15, 2019 Category: ENT & OMF Authors: JULIA TURRA RIBEIRO, FERNANDA BROCHIER CARDOSO, MICHELLE ROXO GON ÇALVES, LUAN NATHIEL SANTANA KOVALSKI, VINICIUS COELHO CARRARD, MANOELA DOMINGUES MARTINS, MARCO ANTONIO TREVIZANI MARTINS Source Type: research

Cardiovascular Effects of Sodium-Glucose Cotransporter-2 Inhibitors in Adults With Type 2 Diabetes
Publication date: Available online 24 September 2019Source: Canadian Journal of DiabetesAuthor(s): Vincent C. WooAbstractAdults with type 2 diabetes mellitus can benefit from pharmacotherapies that lower their risk for cardiovascular disease. This review describes the salient findings from sodium-glucose cotransporter-2 (SGLT2) inhibitor cardiovascular outcome trials that serendipitously revealed the cardiorenal benefits of SGLT2 inhibitors in adults with type 2 diabetes mellitus who either have established cardiovascular disease or multiple cardiovascular risk factors. It also summarizes the findings from other phase 3 cl...
Source: Canadian Journal of Diabetes - December 13, 2019 Category: Endocrinology Source Type: research

Evidence-based reduction of cardiovascular risk in patients with diabetes.
Authors: Schütt KA Abstract Patients with type 2 diabetes mellitus exhibit a markedly increased propensity to develop cardiovascular diseases, such as myocardial infarction, stroke and heart failure. The results from large cardiovascular outcome trials conducted in recent years with novel hypoglycemic agents, such as dipeptidyl peptidase 4 (DPP-4) inhibitors, sodium-glucose transporter 2 (SGLT2) inhibitors and glucagon-like peptide 1 (GLP-1) receptor agonists have led to novel therapeutic strategies to reduce the cardiovascular risk in patients with diabetes. This overview article summarizes the evidence derived ...
Source: Herz - December 12, 2019 Category: Cardiology Tags: Herz Source Type: research

Prognostic factors of long-term survival to guide selection of asymptomatic patients for carotid endarterectomy.
CONCLUSIONS: The presence of one or more prognostic factors as well as the various risk prediction models can guide selection of ACS patient subgroups for which a prophylactic CEA should or should not be offered. Decisions to offer prophylactic CEA should weigh in factors like surgeon's experience and hospital expertise/volume. Asymptomatic patients not expected to live long enough to benefit from the procedure should not be considered for CEA, but should be offered best medical treatment. PMID: 31814375 [PubMed - as supplied by publisher]
Source: International Angiology - December 11, 2019 Category: Cardiology Tags: Int Angiol Source Type: research

Pioglitazone for the primary and secondary prevention of cardiovascular and renal outcomes in patients with or at high risk of type 2 diabetes mellitus: a meta-analysis.
CONCLUSIONS: Pioglitazone should be considered in patients with or at high risk of T2DM for the prevention of cardiovascular endpoints, especially in those with a history of established CVD who might benefit the most. Robust reductions in progression of renal disease are seen regardless of baseline renal function degree. PMID: 31822895 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - December 11, 2019 Category: Endocrinology Authors: Zhou Y, Huang Y, Ji X, Wang X, Shen L, Wang Y Tags: J Clin Endocrinol Metab Source Type: research

Inter-Arm Blood Pressure Difference in Diabetes Mellitus and Its Preferential Association with Peripheral Artery Disease.
CONCLUSION: Thus, diabetes mellitus itself was not an independent factor associated with IAD. A larger IAD was preferentially associated with the presence of PAD, and this association was modified by age. PMID: 31813900 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - December 10, 2019 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

En mann i 40- årene med akutt innsettende talevansker og ensidig lammelse.
En mann i 40-årene med akutt innsettende talevansker og ensidig lammelse. Tidsskr Nor Laegeforen. 2019 Dec 10;139(18): Authors: Jahr SH, Myro AZ, Vegge K, Campbell P Abstract BACKGROUND: Stroke has several causes and the diagnostic investigation can be challenging. Neurosyphilis occurs when Treponema pallidum infects the central nervous system, and is a rare cause of stroke. CASE PRESENTATION: A man in in his late forties with diabetes mellitus and overweight presented with headache, speech impairment and right-sided stroke symptoms. He also had cognitive impairment and psychiatric symptoms. He ...
Source: Tidsskrift for den Norske Laegeforening - December 10, 2019 Category: General Medicine Authors: Jahr SH, Myro AZ, Vegge K, Campbell P Tags: Tidsskr Nor Laegeforen Source Type: research

Impact of Cardio-Renal-Metabolic Comorbidities on Cardiovascular Outcomes and Mortality in Type 2 Diabetes Mellitus.
CONCLUSION: In T2DM patients, CKD presence was associated with higher risk of modified MACE, HF, and ACM. This may have risk-stratification implications for T2DM patients based on background CKD and highlights the potential importance of novel renoprotective strategies. PMID: 31812955 [PubMed - as supplied by publisher]
Source: American Journal of Nephrology - December 6, 2019 Category: Urology & Nephrology Authors: Cherney DZI, Repetto E, Wheeler DC, Arnold SV, MacLachlan S, Hunt PR, Chen H, Vora J, Kosiborod M Tags: Am J Nephrol Source Type: research

Metformin for prevention or delay of type 2 diabetes mellitus and its associated complications in persons at increased risk for the development of type 2 diabetes mellitus.
CONCLUSIONS: Metformin compared with placebo or diet and exercise reduced or delayed the risk of T2DM in people at increased risk for the development of T2DM (moderate-quality evidence). However, metformin compared to intensive diet and exercise did not reduce or delay the risk of T2DM (moderate-quality evidence). Likewise, the combination of metformin and intensive diet and exercise compared to intensive diet and exercise only neither showed an advantage or disadvantage regarding the development of T2DM (very low-quality evidence). Data on patient-important outcomes such as mortality, macrovascular and microvascular diabe...
Source: Cochrane Database of Systematic Reviews - December 3, 2019 Category: General Medicine Authors: Madsen KS, Chi Y, Metzendorf MI, Richter B, Hemmingsen B Tags: Cochrane Database Syst Rev Source Type: research

Insulin Resistance in Type 1 Diabetes Mellitus and Its Association with Patient ’s Micro- and Macrovascular Complications, Sex Hormones, and Other Clinical Data
ConclusionsAccording to stratified eGDR, IR was found for one-third of the current T1D population. Insulin resistant patients more frequently had microvascular complications and CVD events. Lower eGDR, longer diabetes duration, and lower HbA1c significantly increased CVD outcomes risk. IR was related to smoking, obesity, gender, age, and diabetes duration. Moreover, men ’s testosterone had a positive correlation with IR in T1D. Finally, patients with T1D and a positive family history of T2D were not susceptible to weight gain, while MS metabolic phenotype prevalence tended to be higher in obese than in lean patients with...
Source: Diabetes Therapy - December 2, 2019 Category: Endocrinology Source Type: research

Prevalence and the Risk Factors for Asymptomatic Carotid Artery Stenosis Among Type II Diabetes Mellitus Patients
Introduction - Stroke is a rising global health burden, particularly among individuals of the third world country. Up to 80% of its etiology is due to underlying carotid artery pathology. Carotid screening therefore would be useful in reducing the rate of stroke among the population.
Source: European Journal of Vascular and Endovascular Surgery - December 1, 2019 Category: Surgery Authors: Lenny Suryani Safri, Md Azim Idris, Hanafiah Harunarashid Source Type: research

Cardiovascular risk factors in patients with premature cardiovascular events attending the University of Dresden Lipid Clinic.
CONCLUSION: In patients with premature CV disease male sex, smoking, hypertension, a positive family history and elevated Lp(a) are the most important CV risk factors. Lp(a) should be considered in the management of young patients with CV disease. PMID: 31818455 [PubMed - in process]
Source: Atherosclerosis Supplements - December 1, 2019 Category: Cardiology Authors: Schatz U, Fischer S, Müller G, Tselmin S, Birkenfeld AL, Julius U, März W, Bornstein SR Tags: Atheroscler Suppl Source Type: research

Genetic Polymorphisms Associated with Thrombotic Disease Comparison of Two Territories: Myocardial Infarction and Ischemic Stroke.
Conclusions: The Thr325Ile polymorphism, but no Ala147Thr polymorphism, represents an independent risk factor for STEMI in the young Mexican population. PMID: 31781299 [PubMed - in process]
Source: Disease Markers - November 30, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

The Role of Cardiovascular and Metabolic Comorbidities in the Link between Atrial Fibrillation and Cognitive Impairment: An Appraisal of Current Scientific Evidence.
Abstract Atrial fibrillation (AF) is the most common arrhythmia encountered in clinical practice with implications on long-term outcomes. Metabolic disorders including diabetes mellitus and obesity are independent predictors of atrial fibrillation and present therapeutic targets to reduce both the incidence and duration burden of atrial fibrillation. The presence of pericardial fat in direct contact with cardiac structures, as well the subsequent release of proinflammatory cytokines, may play an important role in this connection. Atrial fibrillation is an independent predictor of cognitive impairment and dementia....
Source: Medicina (Kaunas) - November 30, 2019 Category: Universities & Medical Training Authors: AlTurki A, Maj JB, Marafi M, Donato F, Vescovo G, Russo V, Proietti R Tags: Medicina (Kaunas) Source Type: research

The Cardiovascular Effects of SGLT2 Inhibitors
Publication date: Available online 24 September 2019Source: Canadian Journal of DiabetesAuthor(s): Vincent C. WooAbstractIndividuals with type 2 diabetes mellitus can benefit from pharmacotherapies that lower their risk for cardiovascular disease. This review describes the salient findings from sodium-glucose cotransporter-2 (SGLT2) inhibitor cardiovascular outcome trials that serendipitously revealed the cardiorenal benefits of SGLT2 inhibitors in individuals with type 2 diabetes mellitus who either have established cardiovascular disease or multiple cardiovascular risk factors. It also summarizes the findings from other ...
Source: Canadian Journal of Diabetes - November 29, 2019 Category: Endocrinology Source Type: research

Incidence and Risk Factors for Dementia in Type 2 Diabetes Mellitus: A Nationwide Population-Based Study in Korea.
CONCLUSION: The optimal management of modifiable risk factors may be important for preventing dementia in subjects with diabetes mellitus. PMID: 31769236 [PubMed - as supplied by publisher]
Source: Diabetes and Metabolism Journal - November 28, 2019 Category: Endocrinology Tags: Diabetes Metab J Source Type: research

The Role of Physical Therapists in Fighting the Type 2 Diabetic Epidemic.
This report 1) describes the diabetes epidemic and the health impact of diabetes and diabetes-related complications, 2) highlights the physical therapist's role as front-line provider, and 3) provides recommendations for physical therapists in screening for diabetes risk factors and diabetes-related complications and considerations for patient management. We focus on type 2 diabetes. J Orthop Sports Phys Ther, Epub 28 Nov 2019. doi:10.2519/jospt.2020.9154. PMID: 31775555 [PubMed - as supplied by publisher]
Source: Physical Therapy - November 28, 2019 Category: Physiotherapy Authors: Harris-Hayes M, Schootman M, Schootman JC, Hastings MK Tags: J Orthop Sports Phys Ther Source Type: research

Screening for non-alcoholic fatty liver disease using liver stiffness measurement and its association with chronic kidney disease and cardiovascular complications in patients with type 2 diabetes.
CONCLUSION: - These results suggest that NAFLD and significant LF (as assessed by FibroScan) are very commonly seen in T2DM outpatients with no known liver disease attending a secondary-care diabetes service, and that increased LF is associated with a greater proportion of chronic vascular complications, especially CKD. PMID: 31786361 [PubMed - as supplied by publisher]
Source: Diabetes and Metabolism - November 28, 2019 Category: Endocrinology Authors: Mantovani A, Turino T, Lando MG, Gjini K, Byrne CD, Zusi C, Ravaioli F, Colecchia A, Maffeis C, Salvagno G, Lippi G, Bonora E, Targher G Tags: Diabetes Metab Source Type: research

Baseline Red Blood Cell Distribution Width as a Predictor of Stroke Occurrence and Outcome: A Comprehensive Meta-Analysis of 31 Studies
Conclusions: Baseline RDW should be integrated into clinical practice as a predictor of ischemic stroke occurrence and outcome. Future studies should also explore the dynamic change of RDW in post-stroke patients to evaluate the clinical significance of RDW and its impact on the inflammatory state of ischemic stroke.
Source: Frontiers in Neurology - November 26, 2019 Category: Neurology Source Type: research