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Condition: Dementia

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Total 2808 results found since Jan 2013.

Neurodegeneration Over 3 Years Following Ischaemic Stroke: Findings From the Cognition and Neocortical Volume After Stroke Study
Conclusions: Ischaemic stroke survivors exhibit greater neurodegeneration compared to stroke-free controls. Brain atrophy is greater in stroke participants who were cognitively impaired early after their stroke. Early cognitive impairment was associated greater subsequent atrophy, reflecting the combined impacts of stroke and vascular brain burden. Atrophy rates could serve as a useful biomarker for trials testing interventions to reduce post-stroke secondary neurodegeneration.Clinical Trail Registration:http://www.clinicaltrials.gov, identifier: NCT02205424.
Source: Frontiers in Neurology - October 22, 2021 Category: Neurology Source Type: research

Leukocyte-derived ratios are associated with late-life any type dementia: a cross-sectional analysis of the Mugello study
AbstractImmunosenescence, vascular aging, and brain aging, all characterized by elevated levels of inflammatory markers, are thought to share a common pathogenetic pathway: inflamm-aging. Retrospective cross-sectional analysis was conducted using data from the Mugello study (Tuscany, Italy), a representative Italian cohort of free-living nonagenarians. to assess the association between specific peripheral inflammation markers derived from white blood cell counts, and the diagnosis of dementia. All the variables of interest were reported for 411 subjects (110 males and 301 females) out of 475 enrolled in the study. Anamnest...
Source: AGE - October 21, 2021 Category: Geriatrics Source Type: research

The value of studying rare genetic variants and other emerging themes in neurogenetics
Although white matter hyperintensities on fluid-attenuated inversion recovery (FLAIR) brain MRI are frequent incidental findings without any apparent clinical abnormality, they are widely viewed as an imaging marker of cerebral small vessel disease1 and indicate future risk of stroke and other adverse outcomes.2 Furthermore, understanding the origin and risk factors for this common entity is crucial because of its contribution to cognitive impairment and dementia.3 Reducing its occurrence will likely help decrease the dementia burden in the community and lower healthcare expenditures.
Source: Brain - October 21, 2021 Category: Neurology Source Type: research

The Protective Effect of Quercetin on Endothelial Cells Injured by Hypoxia and Reoxygenation
Conclusions: Our experiments show that quercetin can protect HBMECs from H/R, which contains promoting cell proliferation, cell migration and angiogenesis, reducing mitochondrial membrane potential damage and inhibiting cell apoptosis. This may be related to its antioxidation and inhibition of endoplasmic reticulum stress. At the same time, quercetin can increase the level of BBB connexin, suggesting that quercetin can maintain BBB integrity.
Source: Frontiers in Pharmacology - October 20, 2021 Category: Drugs & Pharmacology Source Type: research

High blood pressure: The 'simple trick' to lower your blood pressure - 'next to no effort'
HIGH blood pressure, also called hypertension, increases your risk of having a heart attack and stroke. It can also cause kidney failure, heart failure, problems with your sight and vascular dementia. Therefore, it should not be ignored.
Source: Daily Express - Health - October 17, 2021 Category: Consumer Health News Source Type: news

Gender-specific clinical risk scores incorporating blood pressure variability for predicting incident dementia
ConclusionGender-specific clinical risk scores incorporating BP variability can accurately predict incident dementia and can be applied clinically for early disease detection and optimized patient management.
Source: Journal of the American Medical Informatics Association - October 13, 2021 Category: Information Technology Source Type: research

Thyroid status and brain circulation: The Rotterdam Study
CONCLUSIONS: These results suggest that thyroid dysfunction could lead to brain diseases such as stroke or dementia through a suboptimal brain circulation that is potentially modifiable.PMID:34634119 | DOI:10.1210/clinem/dgab744
Source: The Journal of Clinical Endocrinology and Metabolism - October 11, 2021 Category: Endocrinology Authors: Lana Fani Oscar Roa Due ñas Daniel Bos Meike W Vernooij Caroline C W Klaver M Kamran Ikram Robin Peeters M Arfan Ikram Layal Chaker Source Type: research

IJERPH, Vol. 18, Pages 10633: Socio-Economic Disparities in Access to Diagnostic Neuroimaging Services in the United Kingdom: A Systematic Review
This study includes the analysis of diagnostic imaging used for dementia, minor head injury, stroke, cancer, epilepsy, chronic inflammatory demyelinating polyneuropathy and Parkinson’s disease. With this study, we aim to assess the health inequalities at disease diagnosis. Methods: Using Medline (via Ovid), PubMed and Web of Science databases as sources of information, we critically appraise existing studies on neuroimaging use in the U.K. health care system, published between January 2010 and February 2021. Findings: A total of 18 studies were included in this research, revealing that there was an increase in patients o...
Source: International Journal of Environmental Research and Public Health - October 11, 2021 Category: Environmental Health Authors: Aleesha Karia Reza Zamani Mohammad Akrami Tags: Systematic Review Source Type: research

Whole-exome sequencing reveals a role of HTRA1 and EGFL8 in brain white matter hyperintensities
AbstractWhite matter hyperintensities (WMH) are among the most common radiological abnormalities in the ageing population and an established risk factor for stroke and dementia. While common variant association studies have revealed multiple genetic loci with an influence on their volume, the contribution of rare variants to the WMH burden in the general population remains largely unexplored. We conducted a comprehensive analysis of this burden in the UK Biobank using publicly available whole-exome sequencing data (n up to 17 830) and found a splice-site variant inGBE1, encoding 1,4-alpha-glucan branching enzyme 1, to be a...
Source: Brain - October 9, 2021 Category: Neurology Source Type: research

IJERPH, Vol. 18, Pages 10534: Knowledge and Perception of Registered Nurses Regarding the Scope of Practice of Speech-Language Pathologists
Conclusions: It is vital for nurses to understand the value, role, and scope of practice of the SLP. Further educational nursing interventions and training are necessary for effective interprofessional collaboration and teamwork.
Source: International Journal of Environmental Research and Public Health - October 8, 2021 Category: Environmental Health Authors: Sami Alhamidi Majid Alshahwan Regie Tumala Tags: Article Source Type: research

The trend analysis of neurological disorders as major causes of death and disability according to human development, 1990-2019
This study aims to assess the trends in the incidence rate of neurological disorders in developed and developing countries worldwide during 1990-2019. The age-standardized incidence rate (per 100000 persons) of neurological disorders was the primary outcome, extracted from the Global Burden of Disease database for 189 countries and territories from 1990 to 2019. Using the Human Development Index (HDI), countries were classified into developed (HDI ≥ 0.7) and developing (HDI < 0.7) groups. Longitudinal analysis was performed using the Latent Growth Model (LGM) to assess the change in the incidence rate of neurological ...
Source: Environmental Science and Pollution Research International - October 5, 2021 Category: Environmental Health Authors: Nasrin Borumandnia Hamid Alavi Majd Hassan Doosti Keyvan Olazadeh Source Type: research

End of Life Neuropsychological Impairments and Psychological Care of Persons With Advanced Parkinsonism
Am J Hosp Palliat Care. 2021 Oct 4:10499091211049798. doi: 10.1177/10499091211049798. Online ahead of print.ABSTRACTDecline in executive functioning, before frank dementia occurs, has been reported in patients with a history of stroke and malignant brain tumors. This may also be true in patients with advanced Parkinson's disease (PD). In this paper, we summarize the limited research on the motor and cognitive predictors of mortality in advanced PD. We then provide 2 case vignettes of patients with end of life advanced PD who demonstrated a substantial decline in working memory and speech festination. We contrast these pati...
Source: The American Journal of Hospice and Palliative Care - October 5, 2021 Category: Palliative Care Authors: George P Prigatano Naomi Salins Source Type: research

Prediction of post-stroke cognitive impairment using brain FDG PET: deep learning-based approach
CONCLUSION: The DL-based cognitive signature using FDG PET was successfully transferred to an independent stroke cohort. It is suggested that DL-based cognitive evaluation using FDG PET could be utilized as an objective biomarker for cognitive dysfunction in patients with cerebrovascular diseases.PMID:34599654 | DOI:10.1007/s00259-021-05556-0
Source: Molecular Medicine - October 2, 2021 Category: Molecular Biology Authors: Reeree Lee Hongyoon Choi Kwang-Yeol Park Jeong-Min Kim Ju Won Seok Source Type: research

Value of vessel wall magnetic resonance imaging in the diagnosis and management of cerebrovascular diseases
ConclusionIntracranial vessel wall MR imaging is an adjunct to conventional angiographic imaging
Source: QJM - October 1, 2021 Category: Internal Medicine Source Type: research

Blood pressure variability and medial temporal atrophy in apolipoprotein ϵ4 carriers
AbstractBlood pressure variability is an emerging risk factor for dementia but relationships with markers of neurodegeneration and Alzheimer ’s disease risk are understudied. We investigated blood pressure variability over one year and follow-up medial temporal brain volume change in apolipoprotein ϵ4 carriers and non-carriers, and in those with and without Alzheimer’s disease biomarker abnormality. 1051 Alzheimer’s Disease Neuroi maging Initiative participants without history of dementia or stroke underwent 3–4 blood pressure measurements over 12 months and ≥ 1 MRI thereafter. A subset (n = 252) underw...
Source: Brain Imaging and Behavior - September 28, 2021 Category: Neurology Source Type: research

Tongxinluo Exerts Inhibitory Effects on Pyroptosis and Amyloid- < em > β < /em > Peptide Accumulation after Cerebral Ischemia/Reperfusion in Rats
Evid Based Complement Alternat Med. 2021 Sep 16;2021:5788602. doi: 10.1155/2021/5788602. eCollection 2021.ABSTRACTAmyloid-β peptide (Aβ) accumulation is a detrimental factor in cerebral ischemia/reperfusion (I/R) injuries accounting for dementia induced by ischemic stroke. In addition to blood brain barrier (BBB), the glymphatic system mediated by aquaporin-4 (AQP-4) on astrocytic endfeet functions as an important pathway for the clearance of Aβ in the brain. Cerebral I/R induced astrocytic pyroptosis potentially causes the AQP-4 polarization loss and dysfunctional BBB-glymphatic system exacerbating the accumulation of ...
Source: Evidence-based Complementary and Alternative Medicine - September 27, 2021 Category: Complementary Medicine Authors: Bing Wang Zhongkuan Lyu Yuanjin Chan Qiyue Li Li Zhang Kaili Liu Yaming Li Zhonghai Yu Source Type: research

Brain health: Key to health, productivity, and well-being
Alzheimers Dement. 2021 Sep 27. doi: 10.1002/alz.12478. Online ahead of print.ABSTRACTBrain health is essential for physical and mental health, social well-being, productivity, and creativity. Current neurological research focuses mainly on treating a diseased brain and preventing further deterioration rather than on developing and maintaining brain health. The pandemic has forced a shift toward virtual working environments that accelerated opportunities for transdisciplinary collaboration for fostering brain health among neurologists, psychiatrists, psychologists, neuro and socio-behavioral scientists, scholars in arts an...
Source: The Journal of Alzheimers Association - September 27, 2021 Category: Psychiatry Authors: Abolfazl Avan Vladimir Hachinski Brain Health Learn and Act Group Source Type: research

The plasticity of late-onset dementia: A nationwide cohort study in Denmark
DISCUSSION: Most of the observed plasticity in late-onset dementia is associated with a risk decline across successive birth cohorts that is independent of improvements in traditional risk factors.PMID:34569688 | DOI:10.1002/alz.12469
Source: The Journal of Alzheimers Association - September 27, 2021 Category: Psychiatry Authors: Emilie R Hegelund Amar J Mehta Laust H Mortensen Rudi G J Westendorp Source Type: research

Tongxinluo Exerts Inhibitory Effects on Pyroptosis and Amyloid- < em > β < /em > Peptide Accumulation after Cerebral Ischemia/Reperfusion in Rats
Evid Based Complement Alternat Med. 2021 Sep 16;2021:5788602. doi: 10.1155/2021/5788602. eCollection 2021.ABSTRACTAmyloid-β peptide (Aβ) accumulation is a detrimental factor in cerebral ischemia/reperfusion (I/R) injuries accounting for dementia induced by ischemic stroke. In addition to blood brain barrier (BBB), the glymphatic system mediated by aquaporin-4 (AQP-4) on astrocytic endfeet functions as an important pathway for the clearance of Aβ in the brain. Cerebral I/R induced astrocytic pyroptosis potentially causes the AQP-4 polarization loss and dysfunctional BBB-glymphatic system exacerbating the accumulation of ...
Source: Evidence-based Complementary and Alternative Medicine - September 27, 2021 Category: Complementary Medicine Authors: Bing Wang Zhongkuan Lyu Yuanjin Chan Qiyue Li Li Zhang Kaili Liu Yaming Li Zhonghai Yu Source Type: research

Prevalence of Dementia in Korea Based on Hospital Utilization Data from 2008 to 2016
CONCLUSION: Our results demonstrated that hospital utilization for dementia increased significantly from 2008 to 2016, reflecting a proportional increase in the prevalence of dementia. Korean healthcare policy must prioritize dementia treatment.PMID:34558875 | DOI:10.3349/ymj.2021.62.10.948
Source: Yonsei Medical Journal - September 24, 2021 Category: Universities & Medical Training Authors: Yoon Jung Choi Sanghyun Kim Young Jae Hwang Changsoo Kim Source Type: research

Resistance but not endurance exercise training induces changes in cerebrovascular function in healthy young subjects
CONCLUSIONS: Our findings, which were consistent across multiple domains of cerebrovascular function, suggest that episodic increases in arterial pressure associated with resistance training may increase cerebrovascular resistance. The implications of long-term resistance training on brain health require future study, especially in populations with pre-existing cerebral hypoperfusion and/or hypotension.PMID:34559581 | DOI:10.1152/ajpheart.00230.2021
Source: American Journal of Physiology. Heart and Circulatory Physiology - September 24, 2021 Category: Physiology Authors: Hannah J Thomas Channa E Marsh Louise H Naylor Philip N Ainslie Kurt J Smith Howard H Carter Daniel J Green Source Type: research

Prevalence of Dementia in Korea Based on Hospital Utilization Data from 2008 to 2016
CONCLUSION: Our results demonstrated that hospital utilization for dementia increased significantly from 2008 to 2016, reflecting a proportional increase in the prevalence of dementia. Korean healthcare policy must prioritize dementia treatment.PMID:34558875 | PMC:PMC8470559 | DOI:10.3349/ymj.2021.62.10.948
Source: Yonsei Medical Journal - September 24, 2021 Category: Universities & Medical Training Authors: Yoon Jung Choi Sanghyun Kim Young Jae Hwang Changsoo Kim Source Type: research

Resistance but not endurance exercise training induces changes in cerebrovascular function in healthy young subjects
CONCLUSIONS: Our findings, which were consistent across multiple domains of cerebrovascular function, suggest that episodic increases in arterial pressure associated with resistance training may increase cerebrovascular resistance. The implications of long-term resistance training on brain health require future study, especially in populations with pre-existing cerebral hypoperfusion and/or hypotension.PMID:34559581 | DOI:10.1152/ajpheart.00230.2021
Source: American Journal of Physiology. Heart and Circulatory Physiology - September 24, 2021 Category: Physiology Authors: Hannah J Thomas Channa E Marsh Louise H Naylor Philip N Ainslie Kurt J Smith Howard H Carter Daniel J Green Source Type: research

Prevalence of Dementia in Korea Based on Hospital Utilization Data from 2008 to 2016
CONCLUSION: Our results demonstrated that hospital utilization for dementia increased significantly from 2008 to 2016, reflecting a proportional increase in the prevalence of dementia. Korean healthcare policy must prioritize dementia treatment.PMID:34558875 | DOI:10.3349/ymj.2021.62.10.948
Source: Yonsei Medical Journal - September 24, 2021 Category: Universities & Medical Training Authors: Yoon Jung Choi Sanghyun Kim Young Jae Hwang Changsoo Kim Source Type: research

Resistance but not endurance exercise training induces changes in cerebrovascular function in healthy young subjects
CONCLUSIONS: Our findings, which were consistent across multiple domains of cerebrovascular function, suggest that episodic increases in arterial pressure associated with resistance training may increase cerebrovascular resistance. The implications of long-term resistance training on brain health require future study, especially in populations with pre-existing cerebral hypoperfusion and/or hypotension.PMID:34559581 | DOI:10.1152/ajpheart.00230.2021
Source: American Journal of Physiology. Heart and Circulatory Physiology - September 24, 2021 Category: Physiology Authors: Hannah J Thomas Channa E Marsh Louise H Naylor Philip N Ainslie Kurt J Smith Howard H Carter Daniel J Green Source Type: research

Prevalence of Dementia in Korea Based on Hospital Utilization Data from 2008 to 2016
CONCLUSION: Our results demonstrated that hospital utilization for dementia increased significantly from 2008 to 2016, reflecting a proportional increase in the prevalence of dementia. Korean healthcare policy must prioritize dementia treatment.PMID:34558875 | DOI:10.3349/ymj.2021.62.10.948
Source: Yonsei Medical Journal - September 24, 2021 Category: Universities & Medical Training Authors: Yoon Jung Choi Sanghyun Kim Young Jae Hwang Changsoo Kim Source Type: research

Sexual Assault in Women Tied to Increased Stroke, Dementia Risk Sexual Assault in Women Tied to Increased Stroke, Dementia Risk
Brain changes are associated with dementia and stroke in women who suffer traumatic experiences, especially sexual assault.Medscape Medical News
Source: Medscape Neurology and Neurosurgery Headlines - September 23, 2021 Category: Neurology Tags: Psychiatry News Source Type: news

Ephrin-B2 PB-mononuclear cells reduce early post-stroke deficit in diabetic mice but not long-term memory impairment
CONCLUSIONS: Intravenous PB-MNC+ administration the day after stroke induction in diabetic mice improved sensorimotor deficit and reduced infarct volume at the short term, but was unable to prevent long-term memory loss. To what extent diabetes impacts on cell therapy efficacy will have to be specifically investigated in the future. Including vascular risk factors systematically in preclinical studies of cell therapy will provide a comprehensive understanding of the mechanisms potentially limiting cell efficacy and also to identify good and bad responders, particularly in the long term.PMID:34520725 | DOI:10.1016/j.expneurol.2021.113864
Source: Experimental Neurology - September 14, 2021 Category: Neurology Authors: Adrien Cogo Gabrielle Mangin Sarah Mouazan Tatiana Merkulova-Rainon Jean-Pierre Riveline Jean-Fran çois Gautier Mathilde Varret Nathalie Kubis Source Type: research

Management of ischemic stroke in the acute phase
The objective of this article is to provide a general overview of the current management of patients with acute ischemic stroke aiming at improving post-stroke outcome.PMID:34481684 | DOI:10.1016/j.revmed.2021.08.003
Source: Revue de Medecine Interne - September 5, 2021 Category: Internal Medicine Authors: G Duloquin M Graber L Baptiste S Mohr L Garnier M Ndiaye C Blanc-Labarre M Hervieu-B ègue G-V Osseby M Giroud Y B éjot Source Type: research

Stimulation of angiotensin II receptor 2 preserves cognitive function and is associated with an enhanced cerebral vascular density after stroke
In conclusion, C21 prevented cognitive impairment after stroke, likely through a mechanism involving vascular protection and restoration.PMID:34481068 | DOI:10.1016/j.vph.2021.106904
Source: Vascular Pharmacology - September 4, 2021 Category: Drugs & Pharmacology Authors: Wael Eldahshan Mohammed A Sayed Mohamed E Awad Heba A Ahmed Ellen Gillis Waleed Althomali Bindu Pillai Abdulkarim Alshammari Ladonya Jackson Guangkuo Dong Jennifer C Sullivan Marion A Cooley Mohammed Elsalanty Adviye Ergul Susan C Fagan Source Type: research

IJERPH, Vol. 18, Pages 8962: Current Update on the Clinical Utility of MMSE and MoCA for Stroke Patients in Asia: A Systematic Review
Conclusion: Clinicians in Asia are strongly recommended to consider the education level of stroke patients when interpreting the results of the MMSE and MoCA. Further studies in other Asian countries are needed to understand their clinical value in stroke settings.
Source: International Journal of Environmental Research and Public Health - August 25, 2021 Category: Environmental Health Authors: Khaw Subramaniam Abd Aziz Ali Raymond Wan Zaidi Ghazali Tags: Review Source Type: research

A Novel Mutation in COL4A1 Gene in a Chinese Family with Pontine Autosomal Dominant Microangiopathy and Leukoencephalopathy
We report a novel collagen type IV alpha 1 (COL4A1) gene mutation in a Chinese family with PADMAL. The index case was followed up for 6  years. Neuroimaging, whole-exome sequencing, skin biopsy, and pedigree analysis were performed. She initially presented with minor head injury at age 38. MRI brain showed chronic lacunar infarcts in the pons, left thalamus, and right centrum semiovale. Extensive workup was unremarkable except for a patent foramen ovale (PFO). Despite anticoagulation, PFO closure, and antiplatelet therapy, the patient had recurrent lacunar infarcts in the pons and deep white matter, as well as subcortical...
Source: Translational Stroke Research - August 20, 2021 Category: Neurology Source Type: research

Widespread Pain Tied to Dementia, Alzheimer Disease, Stroke
TUESDAY, Aug. 17, 2021 -- Widespread pain, a common subtype of chronic pain, is associated with the subsequent risk for incident dementia, Alzheimer disease dementia, and stroke, according to a study published online Aug. 16 in Regional Anesthesia...
Source: Drugs.com - Pharma News - August 17, 2021 Category: Pharmaceuticals Source Type: news