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Risk factors of intracranial hemorrhage after mechanical thrombectomy of anterior circulation ischemic stroke
ConclusionWake-up strokes and patients who are treated within a drip-and-ship concept are especially vulnerable for symptomatic ICH, while complete recanalization, contrary to subtotal recanalization only, was revealed as a protective factor against ICH.
Source: Neuroradiology - February 18, 2019 Category: Radiology Source Type: research

Uptake in antithrombotic treatment and its association with stroke incidence in atrial fibrillation: insights from a large German claims database
ConclusionBetween 2011 and 2016, the use of guideline-conform antithrombotic therapy in Germany has significantly increased. This was associated with a significant decline in strokes without an increased incidence of bleeding complications.
Source: Clinical Research in Cardiology - February 15, 2019 Category: Cardiology Source Type: research

Comparison of prasugrel and clopidogrel in patients with non-cardioembolic ischaemic stroke: a phase 3, randomised, non-inferiority trial (PRASTRO-I)
Publication date: March 2019Source: The Lancet Neurology, Volume 18, Issue 3Author(s): Akira Ogawa, Kazunori Toyoda, Kazuo Kitagawa, Takanari Kitazono, Takehiko Nagao, Hiroshi Yamagami, Shinichiro Uchiyama, Norio Tanahashi, Masayasu Matsumoto, Kazuo Minematsu, Izumi Nagata, Masakatsu Nishikawa, Shinsuke Nanto, Kenji Abe, Yasuo Ikeda, PRASTRO-I Study GroupSummaryBackgroundThe effect of prasugrel in terms of the prevention of recurrence of ischaemic stroke is unknown. We investigated the non-inferiority of prasugrel to clopidogrel for prevention of ischaemic stroke, myocardial infarction, and death from other vascular causes...
Source: The Lancet Neurology - February 14, 2019 Category: Neurology Source Type: research

ASA: Intensive BP Control Lowers Bleeding Risk in Stroke Patients
TUESDAY, Feb. 12, 2019 -- Stroke patients who receive intensive blood pressure lowering are less likely to suffer brain bleeds when treated with clot-busting therapies, according to a study published online Feb. 7 in The Lancet to coincide with the...
Source: Drugs.com - Pharma News - February 12, 2019 Category: Pharmaceuticals Source Type: news

AHA News: Pregnancy May Raise Risk of Deadliest Type of Stroke
FRIDAY, Feb. 8, 2019 (American Heart Association News) -- The risk of a type of stroke that causes bleeding in the brain is higher among women during pregnancy and in the weeks following delivery, new research finds. While studies have shown that...
Source: Drugs.com - Daily MedNews - February 8, 2019 Category: General Medicine Source Type: news

Dual Antiplatelet Therapy With Cilostazol Cuts Recurrent Stroke Dual Antiplatelet Therapy With Cilostazol Cuts Recurrent Stroke
New results show cilostazol plus aspirin or clopidogrel reduced recurrent stroke rate by half over aspirin or clopidogrel alone in high-risk stroke patients without increased bleeding.Medscape Medical News
Source: Medscape Medical News Headlines - February 7, 2019 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news

Strict Blood Pressure Control Could Help Make Stroke Care Safer
THURSDAY, Feb. 7, 2019 -- For patients who receive clot-busting drugs after a stroke, intensive blood pressure lowering is safe and it reduces their risk of bleeding in the brain, a new study finds. Brain bleeds are a major potential side effect of...
Source: Drugs.com - Daily MedNews - February 7, 2019 Category: General Medicine Source Type: news

Intensive blood pressure lowering safe for clot-buster-treated stroke patients, but...
(American Heart Association) Rapidly lowering blood pressure beyond recommended targets safely reduced the risk of bleeding as a side effect in stroke patients but did not limit post-stroke disability.
Source: EurekAlert! - Medicine and Health - February 7, 2019 Category: International Medicine & Public Health Source Type: news

Interventional closure vs. medical therapy of patent foramen ovale for secondary prevention of stroke: updated meta-analysis
ConclusionsInterventional closure of PFO resulted in significant reduction of stroke and stroke/TIA compared with antiplatelets/anticoagulants with comparable bleeding rates between the groups, whereas AF occurred more frequently in the intervention group. Patients with large shunts had more benefit from interventional closure.
Source: Clinical Research in Cardiology - February 1, 2019 Category: Cardiology Source Type: research

Draining blood from bleeding stroke may prevent death
(American Heart Association) A minimally invasive surgery combining the use of a clot-busting drug and a catheter to drain blood from the brain of hemorrhagic stroke patients reduced swelling and improved patients' prognoses, according to preliminary research.
Source: EurekAlert! - Medicine and Health - January 30, 2019 Category: International Medicine & Public Health Source Type: news

Wearable Electromagnetic Head Imaging System Using Flexible Wideband Antenna Array Based on Polymer Technology for Brain Stroke Diagnosis
Given the increased interest in a fast, portable, and on-spot medical diagnostic tool that enables early diagnosis for patients with brain stroke, a new approach of a wearable electromagnetic head imaging system based on the polymer material is proposed. A flexible low-profile, wideband, and unidirectional antenna array with electromagnetic band gap (EBG) and metamaterial (MTM) unit cells reflector is utilized. The designed antenna consists of a 4 × 4 radiating patch loaded with symmetrical extended open-ended U-slots and fed by combination of series and corporate transmission lines. A mushroom-like 10-EBG unit cell...
Source: IEEE Transactions on Biomedical Circuits and Systems - January 29, 2019 Category: Biomedical Engineering Source Type: research

Study: Aspirin cuts risk for heart attack, stroke, but increases major bleeding risk
Aspirin can help reduce the risk of heart attack and stroke, but it also increases major bleeding in patients who use it regularly, a new study says.
Source: Health News - UPI.com - January 22, 2019 Category: Consumer Health News Source Type: news

Temporary oral anticoagulation after MitraClip - a strategy to lower the incidence of post-procedural stroke?
CONCLUSIONS: Temporary oral anticoagulation might be a strategy to reduce the incidence of stroke within the first 30 days after the MitraClip procedure. Bleeding events were not significantly altered due to temporary oral anticoagulation. PMID: 30650019 [PubMed - as supplied by publisher]
Source: Acta Cardiologica - January 18, 2019 Category: Cardiology Tags: Acta Cardiol Source Type: research

Combination Therapy with Dipyridamole and Clopidogrel for Secondary Stroke Prevention in Aspirin-Intolerant Patients After Myocardial Infarction: Results of a Nationwide Case-Control Study
ConclusionNo differences were observed in the 12-year survival rate between clopidogrel and clopidogrel –dipyridamole groups. The two groups had balanced event-free survival in recurrent stroke, ICH, GI bleeding, and myocardial infarction.
Source: CNS Drugs - January 16, 2019 Category: Neurology Source Type: research

Successful treatment for disseminated intravascular coagulation (DIC) corresponding to phenotype changes in a heat stroke patient
ConclusionThe present case may indicate the clinical significance of monitoring coagulifibrinolytic changes and the potential benefits of anticoagulants for heat stroke-induced DIC.
Source: Journal of Intensive Care - January 15, 2019 Category: Intensive Care Source Type: research

Effects of time delays on the therapeutic outcomes of intravenous thrombolysis for acute ischemic stroke in the posterior circulation: An observational study
ConclusionIrrespective of stroke severity, the therapeutic effects of recanalization after IVT decreased significantly with longer time delays in PCS patients.
Source: Brain and Behavior - January 6, 2019 Category: Neurology Authors: Qiang Huang, Hai ‐qing Song, Qing‐feng Ma, Xiao‐wei Song, Jian Wu Tags: ORIGINAL RESEARCH Source Type: research

Meta-analysis of Stroke and Bleeding Risk in Patients with Various Atrial Fibrillation Patterns Receiving Oral Anticoagulants
Oral anticoagulation therapy (OAT) is a mainstay for stroke prevention in atrial fibrillation (AF) patients. However, whether the risks of stroke/systemic embolic events (SEE) and bleeding events are affected by the type, duration, and frequency of AF in patients receiving OAT has been previously debated. We aimed to determine the risk of stroke/SEE and bleeding events associated with paroxysmal AF compared to persistent or permanent AF among patients who received OAT. Comprehensive literature searches of the Cochrane Library, PubMed/MEDLINE, and EMBASE databases were conducted from inception to July 2018.
Source: The American Journal of Cardiology - December 19, 2018 Category: Cardiology Authors: Weifang Zhang, Youwen Xiong, Lingling Yu, Aizhen Xiong, Huihui Bao, Xiaoshu Cheng Source Type: research

Higher Incidence of Ischemic Stroke in Patients Taking NOACs Higher Incidence of Ischemic Stroke in Patients Taking NOACs
Does the reduced risk of nontraumatic bleeding in patients taking NOACs as opposed to warfarin come at the cost of a higher risk of ischemic stroke?Stroke
Source: Medscape Today Headlines - December 17, 2018 Category: Consumer Health News Tags: Cardiology Journal Article Source Type: news

Updated Meta-analysis on the Closure of Patent Foramen Ovale in Reduction of Stroke Rates: the DEFENSE-PFO Trial Does not Change the Scenario
Conclusion: This meta-analysis found that stroke rates are lower with percutaneously implanted device closure than with medical therapy alone, being these rates modulated by the rates of hypertension, atrial septal aneurysm and effective closure. The publication of a new trial did not change the scenario in the medical literature.
Source: Revista Brasileira de Cirurgia Cardiovascular - December 13, 2018 Category: Cardiovascular & Thoracic Surgery Source Type: research

Association Between Patient and Physician Sex and Physician-Estimated Stroke and Bleeding Risks in Atrial Fibrillation
ConclusionsOur study is the first to examine the association between patient and physician sex influences and stroke and bleeding risk estimation in AF. While there were differences in agreement between physician estimated stroke risk and calculated CHADS2 scores, these differences were small and unlikely to impact clinical practice; further, despite any perceived differences in the accuracy of risk assessment by sex, most patients received anticoagulation.
Source: Canadian Journal of Cardiology - December 4, 2018 Category: Cardiology Source Type: research

Increased Neutrophil-to-lymphocyte Ratios are Associated with Greater Risk of Hemorrhagic Transformation in Patients with Acute Ischemic Stroke.
CONCLUSIONS: Higher level of NLR is associated with greater risk of hemorrhagic transformation in patients with acute ischemic stroke, especially in cardio-embolic stroke. Moreover, the results suggest that therapeutic interventions that may increase the risk of bleeding should be undertaken carefully in the management of AIS patients with higher NLR. PMID: 30514190 [PubMed - as supplied by publisher]
Source: Current Neurovascular Research - December 4, 2018 Category: Neurology Authors: Song Q, Li Y, Wang Y, Wei C, Liu J, Liu M Tags: Curr Neurovasc Res Source Type: research

Clopidogrel and aspirin after ischemic stroke or transient ischemic attack: an updated systematic review and meta-analysis of randomized clinical trials
Conclusions: Among patients who presented with ischemic stroke/TIA, short-course clopidog rel plus aspirin immediately following the index event appears to be more effective than and as safe as monotherapy for secondary stroke prevention.
Source: Journal of Thrombosis and Thrombolysis - December 3, 2018 Category: Hematology Source Type: research

Cost-Effectiveness of Rivaroxaban Compared to Warfarin for Stroke Prevention in Atrial Fibrillation.
CONCLUSIONS: Patients who had been treated with rivaroxaban may be a cost-effective alternative to warfarin for stroke prevention in Korean patients with AF. PMID: 30468041 [PubMed - as supplied by publisher]
Source: Korean Circulation Journal - November 25, 2018 Category: Cardiology Tags: Korean Circ J Source Type: research

Direct oral anticoagulants in the early phase of non valvular atrial fibrillation-related acute ischemic stroke: focus on real life studies
AbstractStrong evidence for the use of direct oral anticoagulants (DOACs) in the early phase of non valvular atrial fibrillation (NVAF)-related acute ischemic stroke (AIS) is lacking, because this kind of patients were excluded from phase III randomized clinical trials (RCT) and ad hoc RCTs are ongoing. In the latest years a lot of real life studies on this topic have been published. The aim of our review was to focus on these. We reviewed the PubMed databases searching articles reporting on DOACs starting time within 2 weeks from AIS onset. We selected fifteen studies, eight with retrospective, six with prospective observ...
Source: Journal of Thrombosis and Thrombolysis - November 23, 2018 Category: Hematology Source Type: research

Updated Meta-analysis on the Closure of Patent Foramen Ovale in Reduction of Stroke Rates: the DEFENSE-PFO Trial Does not Change the Scenario
Objective: We aimed to analyze whether patent foramen ovale (PFO) closure reduces the risk of stroke, assessing also some safety outcomes after the publication of a new trial.Introduction: The clinical benefit of closing a PFO has been an open question, so it is necessary to review the current state of published medical data in regards to this subject.Methods: MEDLINE, EMBASE, CENTRAL/CCTR, SciELO, LILACS, Google Scholar and reference lists of relevant articles were used to search for randomized controlled trials (RCTs) that reported any of the following outcomes: stroke, death, ...
Source: Brazilian Journal of Cardiovascular Surgery - November 22, 2018 Category: Cardiology Source Type: research

Stroke in a Pediatric Immune Thrombocytopenia Case
Conclusion: Stroke in the immune thrombocytopenic clinic is a rare but hard to manage condition. Although its mechanism not understand well, the clinician should be identify and manage it carefully.DisclosuresNo relevant conflicts of interest to declare.
Source: Blood - November 21, 2018 Category: Hematology Authors: Leblebisatan, G., Cil, M., Sasmaz, H. I., Kilinc, Y., Soyupak, S. Tags: 311. Disorders of Platelet Number or Function Source Type: research

Optimizing Stroke and Bleeding Risk Assessment in Patients with Atrial Fibrillation: A Balance of Evidence, Practicality and Precision.
Abstract PMID: 30458556 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - November 20, 2018 Category: Hematology Authors: Proietti M, Mujovic N, Potpara TS Tags: Thromb Haemost Source Type: research

Tenecteplase utility in acute ischemic stroke patients: A clinical review of current evidence
Acute ischemic stroke is leading cause of disability in the United States. Treatment is aimed at reducing impact of cerebral clot burden and life-long disability. Traditional fibrinolytic treatment with recombinant tissue plasminogen activator (tPA) has shown to be effective but at high risk of major bleeding. Multiple studies have evaluated tenecteplase as an alternative to tPA.
Source: The American Journal of Emergency Medicine - November 14, 2018 Category: Emergency Medicine Authors: Amelia Nelson, Gregory Kelly, Richard Byyny, Catherine Dionne, Candice Preslaski, Kevin Kaucher Source Type: research

Dabigatran Versus Rivaroxaban for Secondary Stroke Prevention in Patients with Atrial Fibrillation Rehabilitated in Skilled Nursing Facilities
ConclusionsIn older adults treated with direct-acting oral anticoagulants after ischemic stroke, outcome rates varied considerably by drug and dosage.
Source: Drugs and Aging - November 13, 2018 Category: Geriatrics Source Type: research

Stroke after thoracic endovascular aortic repair: Can you “plug” the problem?
Perioperative stroke has become the main factor determining quality of life in patients undergoing aortic surgery. Complications traditionally associated with aortic surgery, such as myocardial failure or bleeding, now contribute less frequently to mortality in this patient population.
Source: The Journal of Thoracic and Cardiovascular Surgery - November 8, 2018 Category: Cardiovascular & Thoracic Surgery Authors: Florian S. Schoenhoff, Thierry P. Carrel Tags: Editorial Commentary Source Type: research

Commentary: Stroke after thoracic endovascular aortic repair: Can you “plug” the problem?
Perioperative stroke has become the main factor determining quality of life in patients undergoing aortic surgery. Complications traditionally associated with aortic surgery, such as myocardial failure or bleeding, now contribute less frequently to mortality in this patient population.
Source: The Journal of Thoracic and Cardiovascular Surgery - November 8, 2018 Category: Cardiovascular & Thoracic Surgery Authors: Florian S. Schoenhoff, Thierry P. Carrel Tags: Commentary Source Type: research

Ninety-day prognosis of patients receiving direct oral anticoagulants in the early phase of non valvular atrial fibrillation-related acute ischemic stroke: The real life evidence
Patients who receive antithrombotic therapy as secondary prevention in the early phase of non valvular atrial fibrillation (NVAF)-related acute ischemic stroke (AIS) have a better prognosis compared with patients who do not receive antithrombotic treatment [1]. In the VISTA registry the incidence of stroke recurrence, symptomatic intracranial bleeding, all-cause mortality and 90-day modified Rankin Scale (mRS) ≥4 in patients with NVAF-related AIS not receiving antithrombotic treatment was 19.8%, 9.3%, 40.7% and 65.3%, respectively compared with patients receiving vitamin K antagonists (VKAs) (10.6%, 2.9%, 25.5% and 46.6%...
Source: Thrombosis Research - November 3, 2018 Category: Hematology Authors: Luca Masotti, Elisa Grifoni, Alessandro Dei, Vieri Vannucchi, Federico Moroni, Stefano Spolveri, Grazia Panigada, Giancarlo Landini Tags: Letter to the Editors-in-Chief Source Type: research

Cost-Effectiveness Analysis of Direct-Acting Oral Anticoagulants for Stroke Prevention in Thai Patients with Non-Valvular Atrial Fibrillation and a High Risk of Bleeding
ConclusionsFor both societal and payer perspectives, high-dose edoxaban with a price below the country cost-effectiveness threshold should be the first anticoagulant option for Thai patients with non-valvular atrial fibrillation and a high risk of bleeding.
Source: PharmacoEconomics - November 2, 2018 Category: Health Management Source Type: research

Current and emerging pharmacotherapy for ischemic stroke prevention in patients with atrial fibrillation.
Authors: Székely O, Miyazawa K, Lip GYH Abstract INTRODUCTION: Atrial fibrillation (AF) is associated with high morbidity and mortality rates due to thromboembolic complications, and anticoagulation is central to the management of this common arrhythmia to prevent acute thromboembolic events. The traditional anticoagulants: heparin, fondaparinux, and vitamin K antagonists (VKA, e.g. warfarin, acenocoumarol or phenprocoumin) have long served as pharmacotherapy for ischemic stroke prophylaxis. Areas covered: In this review article, the authors provide an overview on current and emerging pharmacotherapy for ischemic ...
Source: Expert Opinion on Pharmacotherapy - October 27, 2018 Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research

AHA: Ozone Pollution May Be Linked to a Type of Bleeding Stroke
THURSDAY, Oct. 18, 2018 (American Heart Association) -- Exposure to the main ingredient in smog may be linked to a type of bleeding stroke, according to new research. Studies have shown an association between clot-caused ischemic stroke, the most...
Source: Drugs.com - Daily MedNews - October 18, 2018 Category: General Medicine Source Type: news

Closure of Patent Foramen Ovale and Cryptogenic Stroke: Unresolved Issues
AbstractPurpose of ReviewThis review summarises the results of randomised trials comparing closure of patent foramen ovale (PFO) with antithrombotic therapy in patients with cryptogenic stroke.Recent FindingsInitially, three randomised trials failed to show superiority of PFO closure over antithrombotic therapy in patients with cryptogenic stroke. Three recently performed trials and the prolongation of an earlier trial provided evidence that PFO closure in patients with cryptogenic stroke and an age range of 18 –60 years is superior to stroke prevention with antiplatelet therapy. PFO closure was not superior to anticoag...
Source: Current Neurology and Neuroscience Reports - October 17, 2018 Category: Neuroscience Source Type: research

XANTUS-EL: A real-world, prospective, observational study of patients treated with rivaroxaban for stroke prevention in atrial fibrillation in Eastern Europe, Middle East, Africa and Latin America
ConclusionsXANTUS-EL confirmed low stroke and major bleeding rates in patients with NVAF from EEMEA and Latin America. The population was younger but with more heart failure and hypertension than XANTUS; stroke/SE rate was similar but major bleeding lower.
Source: The Egyptian Heart Journal - October 5, 2018 Category: Cardiology Source Type: research

Rivaroxaban or aspirin for patent foramen ovale and embolic stroke of undetermined source: a prespecified subgroup analysis from the NAVIGATE ESUS trial
Publication date: Available online 28 September 2018Source: The Lancet NeurologyAuthor(s): Scott E Kasner, Balakumar Swaminathan, Pablo Lavados, Mukul Sharma, Keith Muir, Roland Veltkamp, Sebastian F Ameriso, Matthias Endres, Helmi Lutsep, Steven R Messé, J David Spence, Krassen Nedeltechev, Kanjana Perera, Gustavo Santo, Veronica Olavarria, Arne Lindgren, Shrikant Bangdiwala, Ashkan Shoamanesh, Scott D Berkowitz, Hardi MundlSummaryBackgroundPatent foramen ovale (PFO) is a contributor to embolic stroke of undetermined source (ESUS). Subgroup analyses from previous studies suggest that anticoagulation could reduce recurren...
Source: The Lancet Neurology - October 5, 2018 Category: Neurology Source Type: research

Comparative risks of bleeding, ischemic stroke and mortality with direct oral anticoagulants versus phenprocoumon in patients with atrial fibrillation
ConclusionsWith rivaroxaban, no significant differences were observed compared to phenprocoumon with regard to hospitalized bleedings or ischemic strokes. Dabigatran was associated with fewer bleedings and a similar risk of ischemic strokes compared to phenprocoumon. Apixaban was also associated with fewer bleedings but was unexpectedly associated with more ischemic strokes, possibly reflecting selective prescribing. The association of rivaroxaban with higher all-cause mortality unrelated to bleedings or strokes has been described previously but remains to be explained.
Source: European Journal of Clinical Pharmacology - October 1, 2018 Category: Drugs & Pharmacology Source Type: research

Modeling the impact of real-world adherence to once-daily (QD) versus twice-daily (BID) non-vitamin K antagonist oral anticoagulants on stroke and major bleeding events among non-valvular atrial fibrillation patients.
CONCLUSION: QD NOACs prevented a significant number of strokes and caused no significant increase in MBs compared to BID NOACs which leads to significant net cost savings for NVAF patients in the US. PMID: 30265159 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - September 29, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Anticoagulation for Stroke Prevention in Older Adults with Atrial Fibrillation and Comorbidity: Current Evidence and Treatment Challenges.
Authors: Sabbag A, Yao X, Siontis KC, Noseworthy PA Abstract The burden of atrial fibrillation (AF) is projected to increase substantially over the next decade in parallel with the aging of the population. The increasing age, level of comorbidity, and polypharmacy will complicate the treatment of older adults with AF. For instance, advanced age and chronic kidney disease have been shown to increase the risk of both thromboembolism and bleeding in patients with AF. Frailty, recurrent falls and polypharmacy, while very common among elderly patients with AF, are often overlooked in the clinical decision making despite...
Source: Korean Circulation Journal - September 22, 2018 Category: Cardiology Tags: Korean Circ J Source Type: research

Stroke volume variation and intraoperative bleeding during functional endoscopic sinus surgery.
Authors: Dauri M, Di Mauro R, Lucci F, Martino F, Silvi MB, Gidaro E, Di Lorenzo S, Toschi N, Di Girolamo S PMID: 30226345 [PubMed - as supplied by publisher]
Source: Minerva Anestesiologica - September 20, 2018 Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research

In embolic stroke of undetermined source, rivaroxaban vs aspirin did not reduce recurrence and increased bleeding.
PMID: 30242405 [PubMed - in process]
Source: Annals of Internal Medicine - September 18, 2018 Category: Internal Medicine Authors: Frieden RW Tags: Ann Intern Med Source Type: research

The relationship between brain microbleeds and homeostatic markers in the treatment of ischemic stroke.
CONCLUSION: Pathogenesis of AF is involved abnormal changes of hemostasis, endothelial dysfunction, antithrombotic state and inflammation. The homeostatic markers, which play role in these pathways, and the presence of BMBs could use to form a prognostic clinic assessment tool to predict bleeding risk. PMID: 30207930 [PubMed - as supplied by publisher]
Source: Neurological Research - September 14, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Oral Dipyridamole-Associated Circulatory Collapse
Extended-release dipyridamole plus aspirin is widely used for secondary prevention of ischemic stroke, although the molecular pharmacodynamics of dipyridamole are not completely determined. Adverse effects of fixed-dose combination of aspirin and dipyridamole include headache, bleeding, and gastrointestinal events. Previously, intravenous infusion of dipyridamole in cardiac stress testing has been associated with cardiogenic shock and pulmonary edema. Herein, we report a case study of a 72-year-old man, presented with a transient ischemic attack who suffered a circulatory collapse after an oral dose of 200 mg extended-release dipyridamole.
Source: Journal of Stroke and Cerebrovascular Diseases - September 2, 2018 Category: Neurology Authors: Pasi Jolma, Jyrki Ollikainen, Ilkka Uurto Source Type: research

Oral anticoagulant use for stroke prevention in atrial fibrillation patients with difficult scenarios
Publication date: September 2018Source: IJC Heart & Vasculature, Volume 20Author(s): Ting-Yung Chang, Jo-Nan Liao, Tze-Fan Chao, Jennifer Jeanne Vicera, Chin-Yu Lin, Ta-Chuan Tuan, Yenn-Jiang Lin, Shih-Lin Chang, Li-Wei Lo, Yu-Feng Hu, Fa-Po Chung, Shih-Ann ChenAbstractAtrial fibrillation (AF) has become the most prevalent arrhythmia and it will increase the risk of ischemic stroke, heart failure, mortality, sudden cardiac death, myocardial infarction, and dementia. Stroke prevention with oral anticoagulant is crucial for management of AF patients. Vitamin K antagonist, which inhibits the clotting factors II, VII, IX and X...
Source: IJC Heart and Vasculature - September 1, 2018 Category: Cardiology Source Type: research

Acute diffuse and transient thyroid swelling after intravenous thrombolysis for acute ischemic stroke: A case report
Rationale: Intravenous thrombolysis is the primary therapy for acute ischemic stroke (AIS), but it has some complications, including symptomatic intracranial hemorrhage, orolingual angioedema, and extracranial bleeding. However, thyroid disorders associated with thrombolysis are very rare. Patient concerns: A 56-year-old man developed acute pain and neck swelling after thrombolysis with recombinant tissue plasminogen activator. Diagnoses: Ultrasound revealed a diffusely enlarged thyroid with linear hypoechoic areas throughout the entire gland, resembling a “cracked” appearance. Interventions: The patient was...
Source: Medicine - September 1, 2018 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Studies: Low-Dose Aspirin May Not Prevent Initial Heart Attack, Stroke
Taking a low-dose aspirin every day has long been known to cut the chances of another heart attack, stroke or other heart problem in people who already have had one, but the risks don’t outweigh the benefits for most other folks, major new research finds. Although it’s been used for more than a century, aspirin’s value in many situations is still unclear. The latest studies are some of the largest and longest to test this pennies-a-day blood thinner in people who don’t yet have heart disease or a blood vessel-related problem. One found that aspirin did not help prevent first strokes or heart attacks...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - August 27, 2018 Category: Consumer Health News Authors: Health – CBS Boston Tags: Boston News Health Healthwatch aspirin Source Type: news

Brain scan checklist set to boost care for stroke survivors
People who suffer a stroke caused by bleeding in the brain could be helped by four simple checks of their brain scans, research suggests. The checks could help spot people at risk of further bleeding so they can be monitored more closely.
Source: Medical Research Council General News - August 15, 2018 Category: Research Source Type: news

Direct oral anticoagulants for stroke prevention in atrial fibrillation: treatment outcomes and dosing in special populations.
CONCLUSIONS: Overall, results of secondary analyses indicate that the recommended dosing strategy for each of the DOACs produces a consistent anticoagulant effect across a diverse patient population, including those at increased risk of stroke or bleeding. PMID: 30081727 [PubMed - in process]
Source: Adv Data - August 9, 2018 Category: Epidemiology Authors: Stacy ZA, Richter SK Tags: Ther Adv Cardiovasc Dis Source Type: research