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Total 12509 results found since Jan 2013.

E-261 Variability of response on prophylactic prasugrel for endovascular treatment of intracranial aneurysms: clinical implications
ConclusionIn the neurointerventional field, high BMI and prior use of antithrombotic agents were related to HTPR, and low BMI was associated with LTPR on prophylactic prasugrel. High hematocrit levels decreased the risk of HTPR. When preparing endovascular treatment for intracranial aneurysms, attention to patients with these clinical features is required to address the possibility of ischemic or bleeding complications.Abstract E-261 Table 1Risk factor analysis of high on-treatment platelet reactivity (HTPR) Variables Univariate Analysis Multivariate Analysis OR (95% CI) P OR (95% CI) P Age 1.02 (0.97-1.06) 0.53 Female o...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Son, Y., Hong, N. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research

Incidence of Ischemic Stroke in Seniors Not Reduced by Low-Dose Aspirin
FRIDAY, July 28, 2023 -- For healthy older adults, low-dose aspirin does not reduce the risk for ischemic stroke but is associated with an increased risk for intracranial bleeding, according to a study published online July 26 in JAMA Network...
Source: Drugs.com - Pharma News - July 28, 2023 Category: Pharmaceuticals Source Type: news

A meta-analysis evaluating efficacy and safety of colchicine for prevention of major cardiovascular events in patients with coronary artery disease
ConclusionsColchicine is an effective, relatively safe drug that could be considered for the treatment of CAD. However, we need to pay attention to the increasing occurrence of non-cardiovascular mortality and infection especially pneumonia possibly caused by colchicine.Graphical abstractEfficacy and safety of colchicine for patients with CAD.CAD coronary artery disease;RCTs randomized controlled trials;OR odds ratio;MACEs major adverse cardiovascular events;ACS acute coronary syndrome;NNT number needed to treat;NNH number needed to harm
Source: Clinical Research in Cardiology - July 28, 2023 Category: Cardiology Source Type: research

Ischemic Stroke in Cancer: Mechanisms, Biomarkers, and Implications for Treatment
Semin Thromb Hemost DOI: 10.1055/s-0043-1771270Ischemic stroke is an important cause of morbidity and mortality in cancer patients. The underlying mechanisms linking cancer and stroke are not completely understood. Long-standing and more recent evidence suggests that cancer-associated prothrombotic states, along with treatment-related vascular toxicity, such as with chemotherapy and immunotherapy, contribute to an increased risk of ischemic stroke in cancer patients. Novel biomarkers, including coagulation, platelet and endothelial markers, cell-free DNA, and extracellular vesicles are being investigated for their potentia...
Source: Seminars in Thrombosis and Hemostasis - July 28, 2023 Category: Hematology Authors: Costamagna, Gianluca Navi, Babak B. Beyeler, Morin Hottinger, Andreas F. Alberio, Lorenzo Michel, Patrik Tags: Review Article Source Type: research

Quest for the Perfect Anticoagulant
The current referenced meta-analysis study by Selvaraj et al1 examines the relative merits of anticoagulation with a direct oral anticoagulant (DOAC) versus vitamin K antagonist (VKA) after transcatheter aortic valve implantation (TAVI) in patients meeting the indications for anticoagulation because of atrial fibrillation (AF). Although guidelines vary, the general consensus appears to indicate noninferiority to superiority of DOACs in the treatment of nonvalvular AF. In the landmark Apixiban for Reduction In Stroke and Other Thromboemoblic Events in Atrial Fibrillation trial comparing apixaban to warfarin in patients with...
Source: The American Journal of Cardiology - July 27, 2023 Category: Cardiology Authors: Bryant Fisher, Danny Chu Source Type: research

For healthy older people, aspirin could cause more bleeding.
A new analysis of older people who have never had a heart attack or stroke suggests limited protective power of daily low-dose aspirin, and worrisome side effects.
Source: NYT Health - July 26, 2023 Category: Consumer Health News Authors: Emily Baumgaertner Tags: your-feed-science Heart Aspirin Elderly Research Falls Clinical Trials Stroke Drugs (Pharmaceuticals) Preventive Medicine Brain Age, Chronological JAMA (Journal of American Medical Assn) United States Preventive Services Task For Source Type: news

Direct current cardioversion practices following percutaneous left atrial appendage closure
DiscussionThere is a widely varied practice pattern of TEE, CCTA, and OAC use with DCCV after LAAC, with a 6% rate of LAT/DRT. LAA imaging before DCCV appears prudent in all cases, especially within 1 year of LAAC, to assess for device position, PDL, and LAT/DRT.
Source: Journal of Cardiovascular Electrophysiology - July 26, 2023 Category: Cardiology Authors: Sapan Bhuta, Adnan Shaaban, Nkongho C. Binda, James Antaki, Ralph S. Augostini, Steven J. Kalbfleisch, Salvatore J. Savona, Toshimasa Okabe, Mahmoud Houmsse, Muhammad R. Afzal, Emile G. Daoud, John D. Hummel Tags: ORIGINAL ARTICLE Source Type: research

Endovascular Treatment of Brain Arteriovenous Malformations in Pediatric Patients: A Single Center Experience and Review of the Literature
Conclusion Our experience supports the effectiveness and safety of endovascular treatment of bAVM in selected pediatric patients. A multidisciplinary approach combining surgery and SRS is warranted to achieve higher complete bAVM obliteration rates. Long-term follow-up is important as these lesions may show recurrence over time, especially in the pediatric population. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Journal of Neurological Surgery Part A: Central European Neurosurgery - July 26, 2023 Category: Neurosurgery Authors: Borges de Almeida, Gon çalo Pamplona, Jaime Baptista, Mariana Carvalho, Rui Concei ção, Carla Lopes da Silva, Rita Sagarribay, Amets Reis, Jo ão Fragata, Isabel Tags: Original Article Source Type: research

Percutaneous left atrial appendage closure in patients with gastrointestinal bleeding associated with oral anticoagulants
CONCLUSIONS: LAAC could be a safe and effective alternative to OAC in patients with non-valvular AF presenting significant, recurrent or potentially unresolvable GIB. This intervention also leads to important savings in the consumption of healthcare resources.PMID:37489111 | DOI:10.1080/00365521.2023.2239973
Source: Scandinavian Journal of Gastroenterology - July 25, 2023 Category: Gastroenterology Authors: Patricia Sanz Segura Javier Jimeno S ánchez Jos é Miguel Arbonés-Mainar Juan S ánchez-Rubio Lezcano Gabriel Galache Osuna Vanesa Bernal Monterde Source Type: research

Three-year outcomes of A Randomized Multicentre Trial Comparing Revascularization and Optimal Medical Therapy for Chronic Total Coronary Occlusions (EuroCTO)
CONCLUSIONS: At 3 years there was no difference in the rate of cardiovascular death or myocardial infarction between PCI or OMT among patients with a remaining single coronary CTO. The MACE rate was higher in the OMT group due largely to ischaemia-driven revascularisation. CTO PCI appears to be a safe option for patients with a single remaining significant coronary CTO. CinicalTrials.gov: NCT01760083.PMID:37482940 | DOI:10.4244/EIJ-D-23-00312
Source: EuroIntervention - July 24, 2023 Category: Cardiovascular & Thoracic Surgery Authors: Gerald S Werner David Hildick-Smith Victoria Martin Yuste Nicolas Boudou Georgios Sianos Valery Gelev Jose Ramon Rumoroso Andrejs Erglis Evald Hoj Christiansen Javier Escaned Carlo di Mario Luis Teruel Alexander Bufe Bernward Lauer Alfredo Ruggero Galassi Source Type: research