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Total 624 results found since Jan 2013.

Risk of thromboembolic events and associated risk factors, including treatments, in patients with immune-mediated diseases
This study assessed the association between thromboembolic events (TEs) and immune-mediated diseases (IMDs) and characterized the risk profile of TEs among patients with IMDs.METHODS: An administrative claims database (2014-2018) was used to identify adults with ≥2 diagnoses on different dates for ≥1 IMD (IMD cohort; ankylosing spondylitis, atopic dermatitis, inflammatory bowel disease, multiple sclerosis, psoriasis, psoriatic arthritis, rheumatoid arthritis, and systemic lupus erythematosus); patients without an IMD diagnosis were assigned to the non-IMD cohort. Patients in the IMD cohort were matched 1:1 to patients ...
Source: Clinical Therapeutics - July 9, 2021 Category: Drugs & Pharmacology Authors: Juliana Setyawan Fan Mu Andres Yarur Miriam L Zichlin Hongbo Yang Catherine Fernan Emma Billmyer Nathaniel Downes Nassir Azimi Vibeke Strand Source Type: research

Cancers, Vol. 13, Pages 3368: Physical Comorbidities and Depression in Recent and Long-Term Adult Cancer Survivors: NHANES 2007 –2018
Cancers, Vol. 13, Pages 3368: Physical Comorbidities and Depression in Recent and Long-Term Adult Cancer Survivors: NHANES 2007–2018 Cancers doi: 10.3390/cancers13133368 Authors: Dafina Petrova Andrés Catena Miguel Rodríguez-Barranco Daniel Redondo-Sánchez Eloísa Bayo-Lozano Rocio Garcia-Retamero José-Juan Jiménez-Moleón María-José Sánchez Many adult cancer patients present one or more physical comorbidities. Besides interfering with treatment and prognosis, physical comorbidities could also increase the already heightened psychological risk of cancer patients. To test this possibility, we...
Source: Cancers - July 5, 2021 Category: Cancer & Oncology Authors: Dafina Petrova Andr és Catena Miguel Rodr íguez-Barranco Daniel Redondo-S ánchez Elo ísa Bayo-Lozano Rocio Garcia-Retamero Jos é-Juan Jiménez-Moleón Mar ía-José Sánchez Tags: Article Source Type: research

Pharmacological Inhibition of the Nod-Like Receptor Family Pyrin Domain Containing 3 Inflammasome with MCC950
Pharmacol Rev. 2021 Jul;73(3):968-1000. doi: 10.1124/pharmrev.120.000171.ABSTRACTActivation of the Nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasome drives release of the proinflammatory cytokines interleukin (IL)-1β and IL-18 and induces pyroptosis (lytic cell death). These events drive chronic inflammation, and as such, NLRP3 has been implicated in a large number of human diseases. These range from autoimmune conditions, the simplest of which is NLRP3 gain-of-function mutations leading to an orphan disease, cryopyrin-associated period syndrome, to large disease burden indications, such as atheroscl...
Source: Pharmacological Reviews - June 12, 2021 Category: Drugs & Pharmacology Authors: Sarah E Corcoran Reena Halai Matthew A Cooper Source Type: research

Development and validation of a nomogram for predicting stroke risk in rheumatoid arthritis patients
In conclusion, the nomogram can be used for individualized preoperative prediction of stroke risk in RA patients.PMID:34081620 | DOI:10.18632/aging.203071
Source: Aging - June 3, 2021 Category: Biomedical Science Authors: Fangran Xin Lingyu Fu Bowen Yang Haina Liu Tingting Wei Cunlu Zou Bingqing Bai Source Type: research

Associations between High-Sensitivity C-Reactive Protein and Non-Communicable Diseases in an Asian Population: Findings from the IFLS Study
Biomarkers. 2021 May 29:1-34. doi: 10.1080/1354750X.2021.1936177. Online ahead of print.ABSTRACTThere has been no comprehensive study on how high-sensitivity C-reactive protein (hs-CRP) level, a biomarker of inflammation, is associated with subsequent diagnoses of various non-communicable diseases (NCDs) in Asians. Our study is the first to do so to better compare these associations in an Asian population. This is a nationwide longitudinal study of 3,410 male and 4,004 female participants of the RAND Indonesian Family Life Survey with a mean age of 42.4 years, to examine associations between increasing hs-CRP levels and ri...
Source: Biomarkers - May 31, 2021 Category: Research Authors: Nirmin Juber Chien-Chang Lee Jason J Liu Source Type: research

A Novel Approach to New-Onset Hemiplegic Shoulder Pain With Decreased Range of Motion Using Targeted Diagnostic Nerve Blocks: The ViVe Algorithm
Introduction: Hemiplegic shoulder pain (HSP) is the most common pain disorder after stroke with incidence estimates of 30–70% and associated with reductions in function, interference with rehabilitation, and a reduced quality of life. Onset may occur as soon as a week after stroke in 17% of patients. Management of HSP represents a complex treatment pathway with a lack of evidence to support one treatment. The pain has heterogeneous causes. In the acute setting, decreased range of motion in the shoulder can be due to early-onset spasticity, capsular pattern stiffness, glenohumeral pathology, or complex regional pain syndr...
Source: Frontiers in Neurology - May 28, 2021 Category: Neurology Source Type: research

Molecules, Vol. 26, Pages 3208: Progress in PET Imaging of Neuroinflammation Targeting COX-2 Enzyme
hn Mann Neuroinflammation and cyclooxygenase-2 (COX-2) upregulation are associated with the pathogenesis of degenerative brain diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), epilepsy, and a response to traumatic brain injury (TBI) or stroke. COX-2 is also induced in acute pain, depression, schizophrenia, various cancers, arthritis and in acute allograft rejection. Positron emission tomography (PET) imaging allows for the direct measurement of in vivo COX-2 upregulation and thereby enables disease staging, therapy evaluation and aid quantifying target occupa...
Source: Molecules - May 27, 2021 Category: Chemistry Authors: Jaya Prabhakaran Andrei Molotkov Akiva Mintz J. John Mann Tags: Review Source Type: research

Clinical characteristics, triggering etiologies, and response of plasmapheresis in thrombotic microangiopathy in Taiwan
This study indicated the spectrum of underlying causes, extra-renal characteristics, and the response to plasmapheresis of patients with TMA in Taiwan. Of note, the poor clinical outcomes of plasmapheresis in patients with TMA might highlight the masked underlying etiology or worse disease condition that should be noticed.
Source: Medicine - May 21, 2021 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

The impact of glucosamine on age-related macular degeneration in patients: A nationwide, population-based cohort study
ConclusionsGlcN treatment can decrease the risk of developing dry type AMD. Further prospective controlled studies are needed to determine the effectiveness of GlcN treatment in patients with AMD and the associated mechanism.
Source: PLoS One - May 19, 2021 Category: Biomedical Science Authors: Kathy Ming Feng Source Type: research

Association between ischemic stroke and seropositive rheumatoid arthritis in Korea: A nationwide longitudinal cohort study
by Dong Hyun Lee, Seung Hun Sheen, Dong-Geun Lee, Jae-Won Jang, Dong Chan Lee, Seung-Ho Shin, In-bo Han, Je Beom Hong, Hakyung Kim, Seil Sohn The purpose of this longitudinal follow-up study was to investigate the risk of ischemic stroke nationwide in patients with seropositive rheumatoid arthritis (RA) and controls who were matched in age and sex. Patient data were collected from the National Health Insurance Service (NHIS) Health Scre ening (HEALS) cohort. Using the International Classification of Diseases code M05 (seropositive RA), with a prescription of any disease-modifying anti-rheumatic drug (DMARD), RA was identi...
Source: PLoS One - May 17, 2021 Category: Biomedical Science Authors: Dong Hyun Lee Source Type: research

Preliminary screening for sarcopenia and related risk factors among the elderly
This study included 200 participants aged 65 or over living in Taiwan, but excluded the following: 1.people with neuromuscular diseases affecting limb function and balance (such as stroke, Parkinson disease, spinal stenosis, and peripheral nerve compression);2.people with fractures in the lower extremities or with arthritis, which could affect mobility;3.people with pacemakers or other medical implant devices; and4.people who declined to participate in the research and people who could not complete all aspects of the research. The prevalence of sarcopenia in the elderly community is approximately 6.0%. It is less pre...
Source: Medicine - May 14, 2021 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Sinomenine activation of Nrf2 signaling prevents inflammation and cerebral injury in a mouse model of ischemic stroke
In conclusion, the findings of the present study identified a novel pathway through which SINO may exert its anti-inflammatory and cerebral protective functions, and provided a molecular basis for the potential applications of SINO in the treatment of cerebral inflammatory disorders.PMID:33968178 | PMC:PMC8097210 | DOI:10.3892/etm.2021.10079
Source: Experimental and Therapeutic Medicine - May 10, 2021 Category: General Medicine Authors: Fangfang Bi Yiyong Zhang Wenbo Liu Keliang Xie Source Type: research

Systemic inflammatory response index as an independent risk factor for ischemic stroke in patients with rheumatoid arthritis: a retrospective study based on propensity score matching
ConclusionSIRI was independently associated with the occurrence of ischemic stroke in patients with RA. Thus, RA patients with elevated SIRI should be closely monitored.Key points•RA patients with IS had fewer traditional risk factors such as hypertension and diabetes, while inflammatory indicators were significantly increased.•The SIRI have drawn attention in recent years as novel non-specific inflammatory markers. However, only a few studies have been conducted to investigate their value in RA.•This study completes the gaps in the research on the relationship between SIRI and the risk of IS occurrence in RA patients.
Source: Clinical Rheumatology - May 9, 2021 Category: Rheumatology Source Type: research

Varicella zoster virus anterior uveitis complicated by thalamic stroke
We report a case of varicella zoster virus (VZV)-associated anterior uveitis in a patient with weight loss, arthritis and signs of inflammatory bowel disease. Her clinical course included the development of a thalamic stroke secondary to VZV cerebral vasculopathy. Following antiviral therapy, the patient ’s neurologic symptoms recovered and her ophthalmic findings improved.
Source: Journal of Ophthalmic Inflammation and Infection - May 1, 2021 Category: Opthalmology Source Type: research

Increased Incidence of Stroke and Transient Ischemic Attack in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis in Germany
Conclusion: RA was significantly associated with stroke and TIA, with young patients being at a particularly increased risk. AS was tendentially associated with stroke and TIA.Neuroepidemiology
Source: Neuroepidemiology - March 31, 2021 Category: Epidemiology Source Type: research

Stroke risk in arthritis: A systematic review and meta-analysis of cohort studies
by Wei Liu, Wei Ma, Hua Liu, Chunyan Li, Yangwei Zhang, Jie Liu, Yu Liang, Sijia Zhang, Zhen Wu, Chenghao Zang, Jianhui Guo, Liyan Li Background and objectiveStroke is a major contributor to the global burden of disease. Although numerous modifiable risk factors (RF) for stroke have been identified, some remain unexplained. Increasing studies have investigated stroke risk in arthritis, but their results are inconsistent. We aimed to synthesize, quantify, and compare the risk of stroke for the major types of arthritis in cohort studies by using a systematic review and meta-analysis approach. MethodsWe searched Chinese and E...
Source: PLoS One - March 16, 2021 Category: Biomedical Science Authors: Wei Liu Source Type: research

Association Between Chronic Inflammatory Diseases and Stroke-Associated Pneumonia – An Epidemiological Study
This study assessed the relationship between chronic inflammatory diseases and stroke-associated pneumonia (SAP).
Source: Journal of Stroke and Cerebrovascular Diseases - January 19, 2021 Category: Neurology Authors: Layne Dylla, Paco S. Herson, Sharon N. Poisson, John D. Rice, Adit A. Ginde Source Type: research

Interleukin-17 and ischemic stroke.
Abstract Interleukin-17 (IL-17) is a cytokine family that includes 6 members, IL-17A through IL-17F, most of them are reported to have pro-inflammatory role. Through binding to their receptors (IL-17Rs), IL-17 activates the intracellular signaling pathways to play an important role in autoimmune diseases, including rheumatoid arthritis (RA) and multiple sclerosis (MS). Ischemic stroke is a complex pathophysiological process mainly caused by regional cerebral ischemia. Inflammatory factors contribute to the physiological process of stroke that leads to poor prognosis. IL-17 plays a crucial role in promoting inflamm...
Source: Immunology - September 15, 2020 Category: Allergy & Immunology Authors: Zhang Q, Liao Y, Liu Z, Dai Y, Li Y, Li Y, Tang Y Tags: Immunology Source Type: research

Cross-diagnostic scale-banking using Rasch analysis: Developing a common reference metric for generic and health condition-specific scales in people with rheumatoid arthritis and stroke.
CONCLUSION: This study provides a transformation table to enable direct comparisons among instruments measuring physical functioning commonly used in rheumatoid arthritis (HAQ) and stroke (FIMTM motor scale), as well as in people with disability in general (WHODAS 2.0). PMID: 32909047 [PubMed - as supplied by publisher]
Source: Journal of Rehabilitation Medicine - September 12, 2020 Category: Rehabilitation Tags: J Rehabil Med Source Type: research

Gout is associated with an increased risk for incident heart failure among older adults: the REasons for Geographic And Racial Differences in Stroke (REGARDS) cohort study
Gout has been associated with a higher risk for coronary heart disease (CHD) and stroke in some prior studies. Few studies have assessed the association of gout with incident heart failure (HF).
Source: Arthritis Research and Therapy - April 16, 2020 Category: Rheumatology Authors: Lisandro D. Colantonio, Kenneth G. Saag, Jasvinder A. Singh, Ligong Chen, Richard J. Reynolds, Angelo Gaffo, Timothy B. Plante, Jeffrey R. Curtis, S. Louis Bridges Jr., Emily B. Levitan, Ninad S. Chaudhary, George Howard, Monika M. Safford, Paul Muntner a Tags: Research article Source Type: research

Adjunctive Chinese Herbal Products Therapy Reduces the Risk of Ischemic Stroke Among Patients With Rheumatoid Arthritis
We performed a retrospective cohort study to investigate the association between the risk of ischemic stroke (IS) and the use of Chinese herbal products (CHP) in combination with western medicine (WM) among patients with rheumatoid arthritis (RA). The data were sourced from the registry for beneficiaries, inpatient and ambulatory care claims, and Registry for Catastrophic Illness from the National Health Insurance Research Database (NHIRD) in Taiwan between 1997 and 2011. Patients, who were newly diagnosed with RA between 1997 and 2010, were classified as the CHP group or non-CHP group depending on the presence of absence ...
Source: Frontiers in Pharmacology - March 3, 2020 Category: Drugs & Pharmacology Source Type: research

Predicting the Risk of Ischemic Stroke among Patients with Rheumatoid Arthritis Using a Simplified RA-CHADSV Score Based on the CHA2DS2-VASc Score.
CONCLUSIONS: A simplified RA-CHADSV score, with comparable efficiency as the CHA2DS2-VASc score, but easier to use clinically was developed for predicting the risk of ischemic stroke among non-AF RA patients. PMID: 32059458 [PubMed - in process]
Source: Medicina (Kaunas) - February 11, 2020 Category: Universities & Medical Training Authors: Hsu CW, Ng KJ, Lu MC, Koo M Tags: Medicina (Kaunas) Source Type: research

An Embolic Stroke in a Patient With PROC p.Lys193del
We report a 58-year-old woman who suddenly developed brain infarction with weakness of the left lower extremity and left perioral dysesthesia during postoperative tamoxifen therapy for breast cancer and prednisolone therapy for rheumatoid arthritis. Diffusion-weighted images detected multiple areas of hyperintensity in the posterior circulation system of the brain. Despite extensive examinations, we could not identify any embolic sources except hypoplasia of the right vertebral artery. We found decreased activity of protein C against its antigen level (activity: 59% versus antigen: 122%) with enhanced activity of coagulati...
Source: Journal of Stroke and Cerebrovascular Diseases - February 10, 2020 Category: Neurology Authors: Kana Ueki, Kuniyuki Nakamura, Yoshinobu Wakisaka, Shinichi Wada, Yoji Yoshikawa, Shinya Matsumoto, Taeko Hotta, Dongchong Kang, Takanari Kitazono, Tetsuro Ago Tags: Case Report Source Type: research

An unusual cause of acute ischemic stroke: Adult Onset Still ’s Disease
We present a case where acute ischemic stroke secondary to a floating internal carotid artery thrombus was an early manifestation of AOSD. The patient also had prolonged high spiking fevers, sign ificant leucocytosis, arthralgias and transaminitis. He responded well to a high dose of oral corticosteroids and was eventually started on anticoagulation for secondary stroke prevention. To our knowledge, this is the first described case of arterial thrombosis associated with AOSD. We postulate th at thrombocytosis, vasculitis and hypercoagulability from the underlying inflammatory state may have contributed to the ischemic stroke.
Source: Journal of Thrombosis and Thrombolysis - December 1, 2019 Category: Hematology Source Type: research

AHA News: Here's Why Stroke Survivors Need to Pay Attention to Bone Health
Title: AHA News: Here's Why Stroke Survivors Need to Pay Attention to Bone HealthCategory: Health NewsCreated: 8/9/2019 12:00:00 AMLast Editorial Review: 8/12/2019 12:00:00 AM
Source: MedicineNet Arthritis General - August 12, 2019 Category: Rheumatology Source Type: news

Use of Chinese herbal medicines by rheumatoid arthritis patients was associated with lower risk of stroke: A retrospective cohort study.
CONCLUSION: The CHMs use was associated with lower risk of stroke for RA patients, suggesting that it could be integrated into conventional therapy to prevent subsequent stroke incident. PMID: 31331548 [PubMed - in process]
Source: Complementary Therapies in Medicine - July 25, 2019 Category: Complementary Medicine Authors: Lai NS, Livneh H, Fan YH, Lu MC, Liao HH, Tsai TY Tags: Complement Ther Med Source Type: research

WHO updates its essential medicines list, adds cancer and stroke drugs
The World Health Organization published an updated list of "essential medicines" on Tuesday, adding drugs for cancer, stroke, rheumatoid arthritis and inflammatory bowel disease among the treatments that should be seen as the standard.
Source: Reuters: Health - July 9, 2019 Category: Consumer Health News Tags: healthNews Source Type: news

Potential benefits of biologics on stroke and mortality in patients with rheumatoid arthritis: A nationwide population ‐based cohort study in Taiwan
ConclusionBiologics used in RA patients have been shown to have a beneficial impact on improving clinical outcomes, including decreased risks of death and stroke. The economic burden from costs of biologics may be alleviated by improving outcomes.
Source: International Journal of Rheumatic Diseases - June 24, 2019 Category: Rheumatology Authors: Chao ‐Hsiun Tang, Fun Yu, Ching‐Ya Huang, Der‐Yuan Chen Tags: ORIGINAL ARTICLE Source Type: research

After a Stroke, Your Bones Need Care
Title: After a Stroke, Your Bones Need CareCategory: Health NewsCreated: 4/25/2019 12:00:00 AMLast Editorial Review: 4/25/2019 12:00:00 AM
Source: MedicineNet Arthritis General - April 25, 2019 Category: Rheumatology Source Type: news

Corticospinal Tract Integrity and Long-Term Hand Function Prognosis in Patients With Stroke
Conclusions: The present study showed that CST integrity (at 6 months after onset) in patients with chronic stroke was related to functional hand status. In addition, the mid-pons FA value was more predictive of functional restoration of the hand than the FN or FA value at the pontomedullary junction. These results may be useful in predicting the functional restoration of the hand and understanding the functional prognosis of stroke. Introduction Restoration of hand function is one of the most important goals for patients with stroke (1). Thus, techniques that aid in predicting restoration of hand function are also i...
Source: Frontiers in Neurology - April 14, 2019 Category: Neurology Source Type: research

Exploring metabolic and inflammatory abnormalities in rheumatoid arthritis patients developing stroke disease: a case-control study using electronic medical record data in northern China
ConclusionsA close monitoring is required for RA patients with dyslipidemia and elevated inflammatory markers, and the primary stroke preventive strategies should be directed against these risk factors.
Source: Clinical Rheumatology - February 7, 2019 Category: Rheumatology Source Type: research

Stroke under treatment with ustekinumab for psoriatic arthritis.
Authors: Aboudiab M, Andréjak M, Husein T, Goëb V PMID: 30638925 [PubMed - as supplied by publisher]
Source: Revue Neurologique - January 16, 2019 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Rheumatoid meningitis: A rare cause of aseptic meningitis with frequently stroke-like episodes
Conclusions RM is a rare manifestation of RA and often presents with stroke-like episodes. It is currently not implemented in the workup of aseptic meningitis in national guidelines. Crucial clues for diagnosis included recurrent stroke-like episodes refractory to antiepileptic treatment, headache and constitutional symptoms, meningeal enhancement on MRI, CSF pleocytosis, and positive serology findings for ACPA and RF. Prognosis is favorable with early immunosuppressive treatment.
Source: Neurology Clinical Practice - October 15, 2018 Category: Neurology Authors: Schuster, S., Braass, H., Iking-Konert, C., Schnoor, U., Matschke, J., Gerloff, C., Thomalla, G., Magnus, T. Tags: Autoimmune diseases, Meningitis, All Clinical Neurology Review Source Type: research

Rheumatoid meningitis presenting with a stroke-like attack treated with recombinant tissue plasminogen activator: a case presentation
Rheumatoid meningitis presenting with a stroke-like attack (RMSA) is a rare manifestation of rheumatoid arthritis (RA). When the patients arrive within the time-window for recombinant tissue plasminogen activa...
Source: BMC Neurology - September 6, 2018 Category: Neurology Authors: Masashi Akamatsu, Futaba Maki, Hisanao Akiyama, Daisuke Hara, Masashi Hoshino and Yasuhiro Hasegawa Tags: Case report Source Type: research

Saving Vanessa, part 1: A mystery rash, a stroke and an epic rescue
Vanessa’s rash first appeared on her arms and legs when she 3 or 4 months old. It was red and bumpy and went away when she was sick with a virus, which happened often. Then it would come back. The dermatology team she saw at Boston Children’s Hospital was puzzled. “I was expecting they were going to think it was nothing, but they took it very seriously,” says Katherine Bell, one of Vanessa’s mothers. “They took a biopsy and very quickly realized they had no idea what it was.” Vanessa’s case was even featured at a regional dermatology conference where doctors take up mystery patients. “A hundred to 150 der...
Source: Thrive, Children's Hospital Boston - July 25, 2017 Category: Pediatrics Authors: Nancy Fliesler Tags: Diseases & Conditions Our Patients’ Stories Dr. Carolyn Rogers Dr. Pui Lee Dr. Robert Sundel Dr. Scellig Stone Dr. Todd Lyons stroke Source Type: news

Risk of fractures after stroke: Results from the Ontario Stroke Registry
Conclusions: Stroke is associated with an increased risk of low-trauma fractures. Individuals with stroke and additional risk factors for fractures may benefit from targeted screening for low bone mineral density and initiation of treatment for fracture prevention.
Source: Neurology - December 25, 2016 Category: Neurology Authors: Kapral, M. K., Fang, J., Alibhai, S. M. H., Cram, P., Cheung, A. M., Casaubon, L. K., Prager, M., Stamplecoski, M., Rashkovan, B., Austin, P. C. Tags: All Health Services Research, All Cerebrovascular disease/Stroke ARTICLE Source Type: research

Increasing comorbidity and health services utilization in older adults with prior stroke
Conclusions: Our findings demonstrate the importance of community-based patient-centered care strategies for stroke survivors that address their range of health needs and prevent more costly acute care use.
Source: Neurology - November 13, 2016 Category: Neurology Authors: Gruneir, A., Griffith, L. E., Fisher, K., Panjwani, D., Gandhi, S., Sheng, L., Patterson, C., Gafni, A., Ploeg, J., Markle-Reid, M. Tags: All Health Services Research, All Cerebrovascular disease/Stroke ARTICLE Source Type: research

Systematic Review and Meta-Analysis of the Efficacy of Interleukin-1 Receptor Antagonist in Animal Models of Stroke: an Update
Summary/AbstractInterleukin-1 receptor antagonist (IL-1 RA) is an anti-inflammatory protein used clinically to treat rheumatoid arthritis and is considered a promising candidate therapy for stroke. Here, we sought to update the existing systematic review and meta-analysis of IL-1 RA in models of ischaemic stroke, published in 2009, to assess efficacy, the range of circumstances in which efficacy has been tested and whether the data appear to be confounded due to reported study quality and publication bias. We included 25 sources of data, 11 of which were additional to the original review. Overall, IL-1 RA reduced infarct v...
Source: Translational Stroke Research - August 14, 2016 Category: Neurology Source Type: research

Cerebrovascular Disease in Rheumatic Diseases: A Systematic Review and Meta-Analysis Clinical Sciences
Conclusions— Risk of any stroke is higher in most rheumatic diseases than in the general population, particularly <50 years. Rheumatoid arthritis and systemic lupus erythematosus increase ischemic and hemorrhagic stroke risk by 60% to 100% relative to the general population.
Source: Stroke - March 27, 2016 Category: Neurology Authors: Wiseman, S. J., Ralston, S. H., Wardlaw, J. M. Tags: Imaging, Cerebrovascular Disease/Stroke, Ischemic Stroke Clinical Sciences Source Type: research

FDA strengthens warning that NSAIDs increase heart attack and stroke risk
Back in 2005, the FDA warned that taking nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen and naproxen increased the risk of having a heart attack or stroke. Last week it took the unusual step of further strengthening this warning. This was done on the advice of an expert panel that reviewed new information about NSAIDs and their risks. Because NSAIDs are widely used, it’s important to be aware of downsides of taking an NSAID and to take steps to limit the risk. Many people take NSAIDs to relieve mild to moderate pain. These medications may be particularly effective in conditions in which pain results pri...
Source: New Harvard Health Information - July 13, 2015 Category: Consumer Health News Authors: Gregory Curfman, MD Tags: Heart Health heart attack heart disease NSAIDS Stroke Source Type: news

Co-Occurrence of Arthritis and Stroke amongst Middle-Aged and Older Adults in Canada.
Authors: Matveev R, Ardern CI Abstract Arthritis is a chronic inflammatory condition commonly associated with mobility restriction and reduced activity. To date, the extent to which arthritis is an independent risk factor for stroke is unclear, and important, in light of an aging population. The purpose of this study was to (i) quantify the cross-sectional association between stroke and arthritis and (ii) to determine whether the relationship differed in physically active and inactivemiddle-aged and older adults. Data was derived from the 2010 Canadian Community Health Survey (N = 47 188; ≥30 y). Multivariabl...
Source: Stroke Research and Treatment - December 2, 2014 Category: Neurology Tags: Stroke Res Treat Source Type: research