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Total 58 results found since Jan 2013.

COL4A1 Mutation as a Cause of Familial Recurrent Intracerebral Hemorrhage
We report a family in which the index case presented with two intracerebral hemorrhages in the basal ganglia with severe periventricular leukoaraiosis and a cataract and vascular tortuosity in the ophthalmological study. His twin brother also had severe leukoaraiosis and multiple subcortical microhemorrhages as well as a congenital cataract and vascular tortuosity in the retina.
Source: Journal of Stroke and Cerebrovascular Diseases - February 4, 2020 Category: Neurology Authors: David Campo-Caballero, Jon Rodriguez-Antig üedad, Jon Ekiza-Bazan, Pablo Iruzubieta-Agudo, Gorka Fernández-Eulate, Amaia Muñoz-Lopetegui, Maite Martínez-Zabaleta, Patricia de la Riva, Miguel Urtasun-Ocariz, Adolfo López de Munain, Ana de Arce Tags: Case Report Source Type: research

A Multicenter Study of Multimorbidity in Older Adult Inpatients in China
ConclusionsMultimorbidity is common in older Chinese inpatients with a national prevalence of 69.3% that increases in line with age. Age, region, area, BMI, and daily activities were independent factors significantly associated with multimorbidity in older inpatients. Clinicians should therefore focus more attention on multimorbidity.
Source: The Journal of Nutrition, Health and Aging - January 10, 2020 Category: Nutrition Source Type: research

An update on clinical, pathological, diagnostic, and therapeutic perspectives of childhood leukodystrophies.
Authors: Ashrafi MR, Amanat M, Garshasbi M, Kameli R, Nilipour Y, Heidari M, Rezaei Z, Tavasoli AR Abstract Introduction: Leukodystrophies constitute heterogenous group of rare heritable disorders primarily affecting the white matter of central nervous system. These conditions are often under-appreciated among physicians. The first clinical manifestations of leukodystrophies are often nonspecific and can occur in different ages from neonatal to late adulthood periods. The diagnosis is, therefore, challenging in most cases.Area covered: Herein, the authors discuss different aspects of leukodystrophies. The authors used...
Source: Expert Review of Neurotherapeutics - December 13, 2019 Category: Neurology Tags: Expert Rev Neurother Source Type: research

Yet Another Health Problem Linked to Air Pollution: Eye Disease
It’s no secret that air pollution isn’t good for your health. In particular, exposure to the byproducts of burning the fuel that powers most of our motor vehicles has been linked to higher risk of lung cancer, respiratory infections, stroke and heart disease, as well as an increased risk of death from these conditions. A new study now adds another worrisome pollution-related risk: eye disease. Dr. Suh-Hang Hank Juo, from the center for myopia and eye disease at China Medical University in Taiwan, and his colleagues documented for the first time in a large population that exposure to two common air pollutants&md...
Source: TIME: Health - August 22, 2019 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized health macular degeneration Pollution Source Type: news

STIR-Net: Deep Spatial-Temporal Image Restoration Net for Radiation Reduction in CT Perfusion
In this study, we finalize extensive experiments to appraise the image restoration performance at different levels of tube current and spatial and temporal resolution scales. The results demonstrate the capability of our STIR-Net to restore high-quality scans at as low as 11% of absorbed radiation dose of the current imaging protocol, yielding an average of 10% improvement for perfusion maps compared to the patch-based log likelihood method.
Source: Frontiers in Neurology - June 26, 2019 Category: Neurology Source Type: research

Application and prospects of butylphthalide for the treatment of neurologic diseases.
CONCLUSIONS: The varied pharmacologic mechanisms of NBP involve many complex molecular mechanisms; however, there many unknown pharmacologic effects await further study. PMID: 31205106 [PubMed - in process]
Source: Chinese Medical Journal - June 18, 2019 Category: General Medicine Authors: Chen XQ, Qiu K, Liu H, He Q, Bai JH, Lu W Tags: Chin Med J (Engl) Source Type: research

Perioperative considerations and anesthesia management in patients with obstructive sleep apnea undergoing ophthalmic surgery
Obstructive sleep apnea (OSA) is a disorder characterized by breathing cessation caused by obstruction of the upper airway during sleep. It is associated with multiorgan comorbidities such as obesity, hypertension, heart failure, arrhythmias, diabetes mellitus, and stroke. Patients with OSA have an increased prevalence of ophthalmic disorders such as cataract, glaucoma, central serous retinopathy (detachment of retina, macular hole), eyelid laxity, keratoconus, and nonarteritic anterior ischemic optic neuropathy; and some might require surgery.
Source: Journal of Cataract and Refractive Surgery - June 4, 2019 Category: Opthalmology Authors: Oya Y. Cok, Edwin Seet, Chandra M. Kumar, Girish P. Joshi Tags: Review/update Source Type: research

Application and prospects of butylphthalide for the treatment of neurological diseases.
CONCLUSIONS: The varied pharmacological mechanisms of NBP involve many complex molecular mechanisms; however, there many unknown pharmacological effects await further study.This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0. PMID: 31107716 [PubMed - as supplied by publisher]
Source: Chinese Medical Journal - May 13, 2019 Category: General Medicine Authors: Chen XQ, Qiu K, Liu H, He Q, Bai JH, Lu W Tags: Chin Med J (Engl) Source Type: research

Sex Difference of Radiation Response in Occupational and Accidental Exposure
Conclusion and Outlook This review summarizes the data from major human studies on the health risks of radiation exposure and shows that sex can potentially influence the prolonged response to radiation exposure (Figure 1 and Tables 1, 2). These data suggest that long-term radiosensitivity in females is higher than that in males who receive a comparable dose of radiation. Our analysis of the literature agrees with the conclusions of the recent report on the Biological effects of ionizing radiation (BEIR VII) published in 2006 by the National Academy of Sciences (NAS), United States (National Research Council, 2006). The B...
Source: Frontiers in Genetics - May 3, 2019 Category: Genetics & Stem Cells Source Type: research

Clinical Improvement Following Stroke Promptly Reverses Post-stroke Cellular Immune Alterations
Conclusions: SIIA are detectable on admission of acute stroke patients. While it was assumed that post-stroke immunosuppression is rapidly reversed with improvement this is the first data set that shows that improvement actually is associated with a rapid reversal of SIIA demonstrating that SIIA require a constant signal to persist. The observation that HMGB-1 serum concentrations were similar in improved and non-improved cohorts argues against a role for this pro-inflammatory mediator in the maintenance of SIIA. Serum miRNA observed to be regulated in stroke in other publications was counter regulated with improvement in ...
Source: Frontiers in Neurology - May 1, 2019 Category: Neurology Source Type: research

A Genetic Variant of miR-34a Contributes to Susceptibility of Ischemic Stroke Among Chinese Population
This study was supported by National Natural Science Foundation of China (Nos. 81560552, 81260234), Natural Science Foundation of Guangxi Zhuang Autonomous Region (CN) (2017JJA180826), Innovation Project of Guangxi Graduate Education (CN) (201601009) and Key Laboratory Open Project Fund of Guangxi Zhuang Autonomous Region (CN) (kfkt20160064). Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Supplementary Material The Supplementary Material for this article can be fou...
Source: Frontiers in Physiology - April 24, 2019 Category: Physiology Source Type: research

Light-Induced Pupillary Responses in Alzheimer's Disease
Light-Induced Pupillary Responses in Alzheimer's Disease Pratik S. Chougule1, Raymond P. Najjar1,2, Maxwell T. Finkelstein1, Nagaendran Kandiah3,4 and Dan Milea1,2,5* 1Department of Visual Neurosciences, Singapore Eye Research Institute, Singapore, Singapore 2The Ophthalmology & Visual Sciences ACP, Duke-National University of Singapore (NUS) Medical School, Singapore, Singapore 3Department of Neurology, National Neuroscience Institute, Singapore, Singapore 4Duke-National University of Singapore (NUS), Singapore, Singapore 5Singapore National Eye Centre, Singapore, Singapore The impact of Alzhe...
Source: Frontiers in Neurology - April 12, 2019 Category: Neurology Source Type: research

Novel protein constituents of pathological ocular pseudoexfoliation syndrome deposits identified with mass spectrometry.
Conclusions: This study expands the understanding of the protein composition of pathological PEX material deposited on the ocular lens in patients with PEX syndrome and provides useful insights into the pathophysiology of this disease. This study together with the previous study by our group (Sharma et al. Experimental Eye Research 2009;89(4):479-85) demonstrate that using neat PEX material, devoid of the underlying lens capsule, for proteomics analysis is an effective approach for deciphering the protein composition of complex and highly insoluble extracellular pathological ocular deposits present in patients with PEX syn...
Source: Molecular Vision - February 6, 2019 Category: Molecular Biology Tags: Mol Vis Source Type: research

One-step management of post-traumatic triple dialysis using two rings.
CONCLUSION: A single-sitting surgery correcting all the three dialysis can curtail the burden of repeated surgeries and their complications, providing early visual recovery and cost-effectivity. PMID: 30270659 [PubMed - as supplied by publisher]
Source: European Journal of Ophthalmology - October 1, 2018 Category: Opthalmology Authors: Gupta S, Selvan H, Shakrawal J, Gupta V Tags: Eur J Ophthalmol Source Type: research

Large-Scale Phenome-Wide Association Study of PCSK9 Variants Demonstrates Protection Against Ischemic Stroke Original Articles
Conclusions: This result represents the first genetic evidence in a large cohort for the protective effect of PCSK9 inhibition on ischemic stroke and corroborates exploratory evidence from clinical trials. PCSK9 inhibition was not associated with variables other than those related to LDL (low-density lipoprotein) cholesterol, atherosclerosis, and type 2 diabetes mellitus, suggesting that other effects are either small or absent.
Source: Circulation: Cardiovascular Genetics - July 11, 2018 Category: Cardiology Authors: Rao, A. S., Lindholm, D., Rivas, M. A., Knowles, J. W., Montgomery, S. B., Ingelsson, E. Tags: Cardiovascular Disease, Diabetes, Type 2, Genetic, Association Studies, Ischemic Stroke Original Articles Source Type: research

Adverse effects of statin therapy: perception vs. the evidence – focus on glucose homeostasis, cognitive, renal and hepatic function, haemorrhagic stroke and cataract
ConclusionLong-term statin treatment is remarkably safe with a low risk of clinically relevant adverse effects as defined above; statin-associated muscle symptoms were discussed in a previous Consensus Statement. Importantly, the established cardiovascular benefits of statin therapy far outweigh the risk of adverse effects.
Source: European Heart Journal - April 27, 2018 Category: Cardiology Source Type: research

Cardiometabolic response of juvenile rainbow trout exposed to dietary selenomethionine
Publication date: Available online 8 March 2018 Source:Aquatic Toxicology Author(s): Connor M. Pettem, Jennifer M. Briens, David M. Janz, Lynn P. Weber Selenium (Se) is considered as an essential trace element, involved in important physiological and metabolic functions for all vertebrate species. Fish require dietary concentrations of 0.1 to 0.5 μg Se/g dry mass (d.m.) to maintain normal physiological and selenoprotein function, however concentrations exceeding 3 μg/g d.m. have been shown to cause toxicity. As Se is reported to have a narrow margin between essentiality and toxicity, there is growing concern surroun...
Source: Aquatic Toxicology - March 9, 2018 Category: Toxicology Source Type: research

Cardiometabolic response of juvenile rainbow trout exposed to dietary selenomethionine.
Abstract Selenium (Se) is considered an essential trace element, involved in important physiological and metabolic functions for all vertebrate species. Fish require dietary concentrations of 0.1-0.5 μg Se/g dry mass (d.m.) to maintain normal physiological and selenoprotein function, however concentrations exceeding 3 μg/g d.m. have been shown to cause toxicity. As Se is reported to have a narrow margin between essentiality and toxicity, there is growing concern surrounding the adverse effects of elevated Se exposure caused by anthropogenic activities. Previous studies have reported that elevated dietary exp...
Source: Aquatic Toxicology - March 8, 2018 Category: Toxicology Authors: Pettem CM, Briens JM, Janz DM, Weber LP Tags: Aquat Toxicol Source Type: research

Chronic Physical Conditions, Multimorbidity, and Mild Cognitive Impairment in Low ‐ and Middle‐Income Countries
ConclusionThese results highlight the need to investigate the underlying mechanisms linking chronic conditions and MCI and whether prevention or treatment of chronic conditions or multimorbidity can reduce the onset of cognitive decline and subsequent dementia, especially in LMICs.
Source: Journal of the American Geriatrics Society - February 10, 2018 Category: Geriatrics Authors: Ai Koyanagi, Elvira Lara, Brendon Stubbs, Andre F. Carvalho, Hans Oh, Andrew Stickley, Nicola Veronese, Davy Vancampfort Tags: Clinical Investigation Source Type: research

Association Between Glucocorticoid Exposure and Healthcare Expenditures for Potential Glucocorticoid-related Adverse Events in Patients with Rheumatoid Arthritis.
CONCLUSION: Chronic exposure to low to medium doses of OGC was associated with significantly increased risk of potential OGC-related AE in patients with RA, and greater cumulative OGC dose was associated with substantially higher AE-related healthcare expenditures among patients with AE. PMID: 29335343 [PubMed - as supplied by publisher]
Source: Journal of Rheumatology - January 18, 2018 Category: Rheumatology Tags: J Rheumatol Source Type: research

Bringing Robotics into the Cath Lab to Protect Physicians
Percutaneous Coronary Intervention (PCI, or angioplasty with stent) is a common procedure used to treat patients with obstructive coronary artery disease, with an estimated 600,000 procedures performed annually in the United States. PCI has a low risk of complications for patients, but that's not the case for clinicians. Patients receive a dose of radiation during a PCI procedure, which takes anywhere from 30 minutes to a few hours. Interventional cardiologists and cardiac catheterization laboratory personnel are exposed to ionizing radiation all day, every day. Protective measures, such as radiation safety caps, goggles...
Source: MDDI - December 15, 2017 Category: Medical Devices Authors: Heather R. Johnson Tags: Medical Device Business Source Type: news

IJERPH, Vol. 14, Pages 1523: Prevalence of Self-Reported Diagnosed Cataract and Associated Risk Factors among Elderly South Africans
e Sokhela This paper estimates the prevalence of self-reported cataract and associated risk factors among individuals aged ≥50 years in South Africa. Data from a nationally-representative cross-sectional Study on Global AGEing and Adult Health (SAGE) (N = 3646) conducted in South Africa from 2007–2008 was analyzed. The primary outcome was self-reported cataract, and exposures included socio-demographics, self-reported co-morbidities, and behavioral factors. Linearized multivariate logistic regression models were used. The weighted prevalence of self-reported diagnosed cataract was 4.4% (95%CI: 3.4–5.8). Prevalenc...
Source: International Journal of Environmental Research and Public Health - December 6, 2017 Category: Environmental Health Authors: Nancy Phaswana-Mafuya Karl Peltzer Amelia Crampin Edmund Ahame Zinhle Sokhela Tags: Article Source Type: research

Molecules, Vol. 22, Pages 2063: Inhibition by Commercial Aminoglycosides of Human Connexin Hemichannels Expressed in Bacteria
Altenberg In addition to gap junctional channels that mediate cell-to-cell communication, connexins form hemichannels that are present at the plasma membrane. Since hemichannels are permeable to small hydrophilic compounds, including metabolites and signaling molecules, their abnormal opening can cause or contribute to cell damage in disorders such as cardiac infarct, stroke, deafness, skin diseases, and cataracts. Therefore, hemichannels are potential pharmacological targets. A few aminoglycosides, well-known broad-spectrum antibiotics, have been shown to inhibit hemichannels. Here, we tested several commercially avai...
Source: Molecules - November 25, 2017 Category: Chemistry Authors: Mariana Fiori Srinivasan Krishnan Abbey Kjellgren Luis Cuello Guillermo Altenberg Tags: Article Source Type: research

Review on antioxidants and evaluation procedures
AbstractAntioxidants are the substances that are capable of counteracting the damaging effects of the physiological process of oxidation occur in animal tissues. These may be nutrients (vitamins and minerals) as well as enzymes (proteins) in our body that assist in chemical reactions. They are believed to play a role in preventing the development of chronic diseases like cancer, diabetes, heart disease, stroke, Alzheimer's disease, rheumatoid arthritis, and cataracts etc. The present review article emphasizes on the various aspects of oxidants and antioxidants viz. definition, types, causes, mechanism, functions, adverse e...
Source: Chinese Journal of Integrative Medicine - October 6, 2017 Category: Internal Medicine Source Type: research

The impact of long-term systemic glucocorticoid use in severe asthma: A UK retrospective cohort analysis.
CONCLUSIONS: Most patients with severe asthma are exposed to SGC, which increases SGC-related AE risk. This suggests that SGC exposure should be minimized as recommended by asthma treatment guidelines. PMID: 28925768 [PubMed - as supplied by publisher]
Source: Journal of Asthma - September 20, 2017 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Role of botulinum toxin A in treatment of intractable diplopia
Conclusions Our results suggest that BTXA offers the advantage of a temporary decrease of the deviation without altering image quality that allows the visual system to recover fusion under real-life conditions. Permanent treatment with surgical correction of the deviation should be reserved for those who achieve fusion during the orthotropic period provided by BTXA.
Source: Journal of American Association for Pediatric Ophthalmology and Strabismus - September 7, 2017 Category: Opthalmology Source Type: research

Endocrine Disruptors and Health Effects in Africa: A Call for Action
Conclusion: To address the many challenges posed by EDCs, we argue that Africans should take the lead in prioritization and evaluation of environmental hazards, including EDCs. We recommend the institution of education and training programs for chemical users, adoption of the precautionary principle, establishment of biomonitoring programs, and funding of community-based epidemiology and wildlife research programs led and funded by African institutes and private companies. https://doi.org/10.1289/EHP1774 Received: 16 February 2017 Revised: 22 May 2017 Accepted: 24 May 2017 Published: 22 August 2017 Address correspond...
Source: EHP Research - August 23, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Commentary Source Type: research

DIS-17-0023 The Enduring Health Challenges of Afghan Immigrants and Refugees in Iran: A Systematic Review
This article does not contain any studies with human participants or animals performed by the author. Data Availability All national (MagIran, Science Information Database (SID) and Iranmedex) and international (PubMed, Scopus) databases were searched from November 2010 to November 2016 using keywords both in English and Persian: Afghan immigrants, Afghan refugees, Iran, infectious diseases, tuberculosis, HIV, Hepatitis B and C, non-communicable disease, food security, mental health, barriers, health insurance, access to health service. All related websites and webpages were also searched by Google with the same keywords ...
Source: PLOS Currents Disasters - July 21, 2017 Category: International Medicine & Public Health Authors: nasim Source Type: research

The Enduring Health Challenges of Afghan Immigrants and Refugees in Iran: A Systematic Review
This article does not contain any studies with human participants or animals performed by the author. Data Availability All national (MagIran, Science Information Database (SID) and Iranmedex) and international (PubMed, Scopus) databases were searched from November 2010 to November 2016 using keywords both in English and Persian: Afghan immigrants, Afghan refugees, Iran, infectious diseases, tuberculosis, HIV, Hepatitis B and C, non-communicable disease, food security, mental health, barriers, health insurance, access to health service. All related websites and webpages were also searched by Google with the same keywords ...
Source: PLOS Currents Disasters - July 21, 2017 Category: International Medicine & Public Health Authors: nasim Source Type: research

Annual incidences of visual impairment during 10-year period in Mie prefecture, Japan
ConclusionsThe results indicate that in Japan, the rates of the major causes of visual impairment altered in the most recent 10-year period reflecting the recent changes in the social background and advances in ocular and systemic treatment.
Source: Japanese Journal of Ophthalmology - April 26, 2017 Category: Opthalmology Source Type: research

Ischemic Optic Neuropathy in Cardiac Surgery Incidence and Risk Factors in the United States from the National Inpatient Sample 1998 to 2013
Conclusions The incidence of ischemic optic neuropathy in cardiac surgery did not change during the study period. Development of ischemic optic neuropathy after cardiac surgery is associated with carotid artery stenosis, stroke, and degenerative eye conditions.
Source: Anesthesiology - April 18, 2017 Category: Anesthesiology Source Type: research

National and sub-national age-sex specific and cause-specific mortality and disability-adjusted life years (DALYs) attributable to household air pollution from solid cookfuel use (HAP) in Iran, 1990-2013.
Abstract National and sub-national mortality, years of life lost due to premature mortality (YLLs), years lived with disability (YLDs) and disability-adjusted life years (DALYs) for household air pollution from solid cookfuel use (HAP) in Iran, 1990-2013 were estimated based on the Global Burden of Disease Study 2013 (GBD 2013). The burden of disease attributable to HAP was quantified by the comparative risk assessment method using four inputs: (1) exposure to HAP, (2) the theoretical minimum risk exposure level (TMREL), (3) exposure-response relationships of related causes (4) disease burden of related causes. Al...
Source: Environmental Research - March 21, 2017 Category: Environmental Health Authors: Abtahi M, Koolivand A, Dobaradaran S, Yaghmaeian K, Mohseni-Bandpei A, Khaloo SS, Jorfi S, Saeedi R Tags: Environ Res Source Type: research

Does early onset cataract increase the risk of ischemic stroke? A nationwide retrospective cohort study
This study was attempted to address the association between early onset cataract (EOC) and ischemic stroke. Using the Longitudinal Health Insurance Database 2000, we established an EOC cohort and a comparison cohort by using 4-fold propensity score matching according to age, gender and comorbidities to detect the incidence of ischemic stroke. A Cox model was used to express the risk of ischemic stroke for the EOC patients compared with the comparison cohort. After adjusting for age, gender and comorbidities of hypertension, diabetes mellitus, hyperlipidemia, coronary artery disease, asthma, chronic obstructive pulmonary...
Source: Internal and Emergency Medicine - December 22, 2016 Category: Emergency Medicine Source Type: research

Clinical features of the pathogenic m.5540g > a mitochondrial transfer rna tryptophan gene mutation
• Longitudinal increase in mtDNA mutant load reflects worsening muscle histology.• De novo m.5540G>A mtDNA mutation adds to its credentials as a pathogenic mutation. • Additional clinical findings are cataract, kidney disease and stroke.
Source: Neuromuscular Disorders - August 18, 2016 Category: Neurology Authors: Yi Shiau Ng, Steven A. Hardy, Venice Shrier, Gerardine Quaghebeur, David R Mole, Matthew J. Daniels, Susan M. Downes, Jane Freebody, Carl Fratter, Monika Hofer, Andrea H. Nemeth, Joanna Poulton, Robert W. Taylor Tags: Case report Source Type: research

Factors influencing nonadministration of thrombolytic therapy in early arrival strokes in a university hospital in Hyderabad, India
Conclusion: One-fourth of early ischemic stroke patients in our study were not thrombolyzed even though they arrived within the window period. The majority of the reasons for nonadministration of thrombolysis were potentially preventable, such as nonaffordability, intrahospital delay, and nonavailability of newer endovascular interventions.
Source: Annals of Indian Academy of Neurology - July 25, 2016 Category: Neurology Authors: Lalitha Pidaparthi Anitha Kotha Venkat Reddy Aleti Abhijeet Kumar Kohat Mridula R Kandadai Suryaprabha Turaga Jabeen A Shaik Suvarna Alladi Meena A Kanikannan Borgohain Rupam Subhash Kaul Source Type: research

Coordinating care for people with long term conditions and dementia: room for improvement
New evidence shows that almost one fifth of people with dementia also have other serious conditions such as stroke, diabetes and visual impairment. Services are not currently designed to provide adequate integrated care for people with dementia plus other conditions. For instance, people with dementia are less likely to get diabetes checks or cataract surgery than those without dementia. Carers are not routinely contacted, and there is a lack of guidance for health professionals covering more than one condition. Implications for practice include incorporating the impact of a diagnosis of dementia on pre-existing conditions...
Source: Current Awareness Service for Health (CASH) - July 12, 2016 Category: Consumer Health News Source Type: news

Qualitative and quantitative analyses of stroke dynamics and microfluidics of phacoemulsification probes operating in different modes
To compare phacoemulsification (phaco) tip movement, microfluidic dynamics, and tip-to-load interaction between longitudinal, torsional, and elliptical ultrasound (US) modalities.
Source: Journal of Cataract and Refractive Surgery - May 1, 2016 Category: Opthalmology Authors: Jaime Zacharias Tags: Laboratory science Source Type: research

Better than Aspirin for Your Heart
If you’ve been diagnosed with heart disease, the chances are you’ve been told to take low-dose aspirin every day as a preventative measure against heart attack and stroke. It’s most commonly prescribed for patients with congestive heart failure. This is the inability of your heart to pump as much blood as your body needs. And this is a big worry to me, because there is very little evidence that aspirin helps. In fact, regular use of aspirin — even baby aspirin — can do you more harm than good. Common Aspirin Beliefs The idea is that aspirin thins the blood, making it easier to pump.  It is also s...
Source: Al Sears, MD Natural Remedies - April 1, 2016 Category: Complementary Medicine Authors: Al Sears Tags: Heart Health Source Type: news

Id: 64: reversible blindness associated with diabetic ketoacidosis: a rare combination
Discussion Sudden painless vision loss has a wide differential diagnosis and it is usually caused by ischemia at retinal, ocular or cortical level. No history of methanol ingestion or trauma, normal fundoscopy, normal MRI and rapid return of vision after correction of diabetic ketoacidosis strongly suggests that blindness was related to acidosis. Alcoholic ketoacidosis has been reported to cause transient reversible blindness in other case reports and correction of acidosis lead to reversal of blindness. Other rare causes of reversible blindness include posterior reversible encephalopathy syndrome, brain tumors, anterior i...
Source: Journal of Investigative Medicine - March 22, 2016 Category: Research Authors: Asad, Z., Chaudhary, A., Awab, A. Tags: Pulmonary/Critical Care Source Type: research

Long-term health of vegetarians & vegans
The Nutrition Society Paper of the Month for February is from Proceedings of the Nutrition Society and is entitled 'The long-term health of vegetarians and vegans'.  The study findings were presented at the 2015 Summer Conference on ‘The future of animal products in the human diet: health and environmental concerns’ during symposium three which focused on alternatives to meat.  Vegetarians are defined as people who do not eat any meat, poultry or fish. They may be sub-classified as lacto-ovo-vegetarians who eat dairy products and/or eggs and vegans who do not eat any animal products. Although vegetarians represent...
Source: The Nutrition Society - February 16, 2016 Category: Nutrition Authors: Cassandra Ellis Source Type: news

Long-term health of vegetarians & vegans
The Nutrition Society Paper of the Month for February is from Proceedings of the Nutrition Society and is entitled ' The long-term health of vegetarians and vegans ' .   The study findings were presented at the 2015 Summer Conference on ‘The future of animal products in the human diet: health and environmental concerns’ during symposium three which focused on alternatives to meat.  Vegetarians are defined as people who do not eat any meat, poultry or fish. They may be sub-classified as lacto-ovo-vegetarians who eat dairy products and/or eggs and vegans who do not eat any animal products. Although vegetarians re...
Source: The Nutrition Society - February 16, 2016 Category: Nutrition Authors: Cassandra Ellis Source Type: news

Long-term health of vegetarians & vegans
The Nutrition Society Paper of the Month for February is from Proceedings of the Nutrition Society and is entitled 'The long-term health of vegetarians and vegans'.  The study findings were presented at the 2015 Summer Conference on ‘The future of animal products in the human diet: health and environmental concerns’ during symposium three which focused on alternatives to meat.  Vegetarians are defined as people who do not eat any meat, poultry or fish. They may be sub-classified as lacto-ovo-vegetarians who eat dairy products and/or eggs and vegans who do not eat any animal products. Although vegetarians represent...
Source: The Nutrition Society - February 16, 2016 Category: Nutrition Authors: Cassandra Ellis Source Type: news

Autism in the Son of a Woman with Mitochondrial Myopathy and Dysautonomia: A Case Report
Conclusion Given emerging evidence that mitochondrial dysfunction, particularly in the electron transport chain needed for cellular energy production, is an underlying pathophysiological mechanism for some varieties of ASD, clinicians should have a high index of suspicion for mitochondrial disease, especially when they encounter a patient with unusual neurological or constitutional symptoms. The prevalence of mitochondrial disease in ASD patients may be as high as five percent, which means that it is not the “zebra”[27] diagnosis that it might be in a non-ASD patient, where prevalence is about 0.01 percent.10 Reference...
Source: Innovations in Clinical Neuroscience - October 9, 2015 Category: Neuroscience Authors: ICN Online Editor Tags: Anxiety Disorders Asperger's syndrome Autism Behavioral and Cognitive Neurology Case Report Current Issue Intellectual Disability Neurologic Systems and Symptoms Pervasive Developmental Disorders ASD autism spectrum disorder dysauton Source Type: research

The effect of blue-blocking intraocular lenses on circadian biological rhythm: protocol for a randomised controlled trial (CLOCK-IOL colour study)
Introduction Blue light information plays an important role in synchronising internal biological rhythm within the external environment. Circadian misalignment is associated with the increased risk of sleep disturbance, obesity, diabetes mellitus, depression, ischaemic heart disease, stroke and cancer. Meanwhile, blue light causes photochemical damage to the retina, and may be associated with age-related macular degeneration (AMD). At present, clear intraocular lenses (IOLs) and blue-blocking IOLs are both widely used for cataract surgery; there is currently a lack of randomised controlled trials to determine whether clear...
Source: BMJ Open - May 12, 2015 Category: Journals (General) Authors: Nishi, T., Saeki, K., Obayashi, K., Miyata, K., Tone, N., Tsujinaka, H., Yamashita, M., Masuda, N., Mizusawa, Y., Okamoto, M., Hasegawa, T., Maruoka, S., Ueda, T., Kojima, M., Matsuura, T., Kurumatani, N., Ogata, N. Tags: Open access, Epidemiology, Ophthalmology Protocol Source Type: research

An Unusual Case Of Cadasil With Occipital Lobe Involvement (P6.006)
CONCLUSION: We discuss the unique features of a rare case of occipital lobe predominant CADASIL lacking the typical anterior temporal lobe involvement. This case exemplifies the heterogeneity of clinical findings that may be associated with NOTCH3 mutations.Disclosure: Dr. Mishra has nothing to disclose. Dr. Rao has nothing to disclose. Dr. Flippen has received personal compensation for activities with MAP Pharmaceuticals/Allergan. Dr. Flippen has received personal compensation in an editorial capacity for the Journal of Graduate Medical Education and Up-To-Date. Dr. Flippen has received Dr. Fogel has received personal com...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Mishra, S., Rao, N., Flippen, C., Fogel, B., Hathout, G., Thomas, M., Kattan, J., Trikamji, B. Tags: Treatments, Therapeutics, and Biomarkers Poster Discussion Session Source Type: research

Why You Should Avoid Statins
At my anti-aging clinic, I continue to wage war against what I call the “medical-industrial complex.” And I do it for one reason only – I care more about my patients than I do about profits. Big Pharma clearly takes the opposite view. And now it seems these pharmaceutical behemoths won’t be happy until every man, woman and child is popping anti-cholesterol pills. Researchers at Duke University recently issued a report recommending that even children and people as young as 30 should be on statins, if they have just slightly elevated cholesterol levels.1 And why wouldn’t researchers at Duke recommen...
Source: Al Sears, MD Natural Remedies - February 3, 2015 Category: Complementary Medicine Authors: Dr. Al Sears Tags: Heart Health Source Type: news

Risk-Benefit Profiles of Women Using Tamoxifen for Chemoprevention
Conclusions: While the majority of women who used tamoxifen for primary prevention of breast cancer were likely to benefit, substantial discontinuation of tamoxifen before five years and use by women at risk of serious side effects may attenuate benefits for breast cancer prevention.
Source: JNCI - December 3, 2014 Category: Cancer & Oncology Authors: Nichols, H. B., DeRoo, L. A., Scharf, D. R., Sandler, D. P. Tags: Article Source Type: research

Impact of diabetes‐related complications on healthcare costs: new results from the UK Prospective Diabetes Study
ConclusionsDiabetic complications are associated with substantial immediate and long‐term healthcare costs. Our comprehensive new estimates of these costs, derived from detailed recent UK Prospective Diabetes Study post‐trial data, should aid researchers and health policy analyses.This article is protected by copyright. All rights reserved.
Source: Diabetic Medicine - November 29, 2014 Category: Endocrinology Authors: M. L. Alva, A. Gray, B. Mihaylova, J. Leal, R. R. Holman Tags: Research Article Source Type: research

The impact of diabetes‐related complications on healthcare costs: new results from the UKPDS (UKPDS 84)
ConclusionsDiabetic complications are associated with substantial immediate and long‐term healthcare costs. Our comprehensive new estimates of these costs, derived from detailed recent UK Prospective Diabetes Study post‐trial data, should aid researchers and health policy analyses.This article is protected by copyright. All rights reserved.
Source: Diabetic Medicine - November 29, 2014 Category: Endocrinology Authors: M. L. Alva, A. Gray, B. Mihaylova, J. Leal, R. R. Holman Tags: Research Article Source Type: research

Stroke Patients Likely Safe To Continue Blood Thinners Before Minor Surgery
A new guideline from the American Academy of Neurology advises that it is likely safe for patients to continue taking blood thinners like aspirin or warfarin before minor procedures such as a cataract operation, minor dental surgery or dermatological procedure. Developed with financial support from the American Academy of Neurology, the guideline appears in the 28 May issue of Neurology, the Academy's official journal...
Source: Health News from Medical News Today - May 30, 2013 Category: Consumer Health News Tags: Stroke Source Type: news