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Condition: Abdominal Aortic Aneurysm

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Total 83 results found since Jan 2013.

Rationale for screening selected patients for asymptomatic carotid artery stenosis.
Authors: Paraskevas KI, Eckstein HH, Mikhailidis DP, Veith FJ, Spence JD Abstract Stroke is a leading cause of death and disability worldwide. Approximately 15% of all first-ever strokes occur due to atheroembolism from a previously undetected/untreated asymptomatic carotid stenosis (ACS). Despite that, international guidelines do not recommend screening for ACS. The rationale for not recommending screening include: a) the harm associated with screening, b) the questionable clinical benefit associated with surgery, c) the lack of proven reduction in the risk of stroke, d) the large number of false positive/false ne...
Source: Current Medical Research and Opinion - January 9, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

Genomic profiling of human vascular cells identifies < i > TWIST1 < /i > as a causal gene for common vascular diseases
by Sylvia T. Nurnberg, Marie A. Guerraty, Robert C. Wirka, H. Shanker Rao, Milos Pjanic, Scott Norton, Felipe Serrano, Ljubica Perisic, Susannah Elwyn, John Pluta, Wei Zhao, Stephanie Testa, YoSon Park, Trieu Nguyen, Yi-An Ko, Ting Wang, Ulf Hedin, Sanjay Sinha, Yoseph Barash, Christopher D. Brown, Thomas Quertermous, Daniel J. Rader Genome-wide association studies have identified multiple novel genomic loci associated with vascular diseases. Many of these loci are common non-coding variants that affect the expression of disease-relevant genes within coronary vascular cells. To identify such genes on a genome-wide level, ...
Source: PLoS Genetics - January 9, 2020 Category: Genetics & Stem Cells Authors: Sylvia T. Nurnberg Source Type: research

Lipid management in people with peripheral artery disease
Purpose of review To summarize recent data on the role of dyslipidaemia and the benefit from managing this in people with disease of the abdominal aorta and its peripheral branches (peripheral artery disease, PAD). Recent findings Findings from the Further Cardiovascular Outcomes Research with Proprotein convertase subtilisin/kexin type 9 (PCSK9) Inhibition in Subjects with Elevated Risk (FOURIER) trial demonstrate the benefit of intensely lowering low-density lipoprotein-cholesterol (LDL-c) in people with PAD to substantially reduce the incidence of major cardiovascular events (MACE; myocardial infarction, stroke or ...
Source: Current Opinion in Lipidology - November 5, 2019 Category: Lipidology Tags: THERAPY AND CLINICAL TRIALS: Edited by Erik S.G. Stroes and Gerald F. Watts Source Type: research

Delphi Study to Reach International Consensus Among Vascular Surgeons on Major Arterial Vascular Surgical Complications
ConclusionVascular surgeons reached international consensus on major and minor complications following AAA, CAD and PAD treatment. This consensus may be helpful in harmonizing the information patients receive and improving standardization of the informed consent procedure. Since major complications differed between diseases, consensus on disease-specific complications to be discussed with patients is necessary.
Source: World Journal of Surgery - July 31, 2019 Category: Surgery Source Type: research

The DIGG risk score : A  risk predictive model of perioperative mortality after elective treatment of intact abdominal aortic aneurysms in the DIGG register.
CONCLUSION: The DIGG risk score can predict risk-adjusted hospital mortality after EVAR and OR of iAAA in the DIGG register. Improvements with respect to the prediction are desirable for OR and should be strived for by extending the model in the future. PMID: 31053898 [PubMed - as supplied by publisher]
Source: Der Chirurg - May 3, 2019 Category: Surgery Authors: Steffen M, Schmitz-Rixen T, Jung G, Böckler D, Grundmann RT, das Deutsche Institut für Gefäßmedizinische Gesundheitsforschung gGmbH (DIGG) Tags: Chirurg Source Type: research

Curcumin, the golden spice in treating cardiovascular diseases.
Abstract Cardiovascular diseases (CVDs) cause the largest mortality worldwide, and much attention has been focused to unravel the mechanisms and optimize the treatment regimens. Curcumin is an important bioactive component of turmeric that has been widely applied as traditional medicine to prevent and treat various diseases in some countries. Recent studies have demonstrated its potent activities in modulating multiple signaling pathways associated with cellular growth, proliferation, survival, inflammation and oxidative stress. The cardiovascular protective properties of curcumin in CVDs have been fully illustrat...
Source: Biotechnology Advances - February 1, 2019 Category: Biotechnology Authors: Li H, Sureda A, Devkota HP, Pittalà V, Barreca D, Silva AS, Tewari D, Xu S, Nabavi SM Tags: Biotechnol Adv Source Type: research

Impact of aortic aneurysms in trans-catheter aortic valve replacement: A single center experience.
CONCLUSIONS: In our patient cohort, 9.5% of patients who underwent TAVR had concomitant aortic aneurysms. Patients with aortic aneurysms had similar incidence of vascular complications as well as in-hospital and 6-month MACE compared to those without. PMID: 30595280 [PubMed - in process]
Source: Indian Heart J - December 1, 2018 Category: Cardiology Authors: Kobayashi A, Lazkani M, Moualla S, Orazio A, Tasset M, Morris M, Fang K, Pershad A Tags: Indian Heart J Source Type: research

What Is the Specificity of the Aortic Dissection Detection Risk Score in a Low ‐prevalence Population?
ConclusionsOur study confirms that in North America the prevalence of AAS in those undergoing advanced imaging is low. The ADD ‐RS in this population has a low specificity. A lack of defined inclusion criteria and a low specificity limits the application of this rule in practice.
Source: Academic Emergency Medicine - November 20, 2018 Category: Emergency Medicine Authors: Robert Ohle, Omar Anjum, Helena Bleeker, Sarah McIsaac, Brian C. Hiestand Tags: Original Contribution Source Type: research

What is the specificity of the aortic dissection detection risk score in a low prevalence population?
CONCLUSIONS: Our study confirms that in North America the prevalence of AAS in those undergoing advanced imaging is low. The ADD-RS in this population has a low specificity. A lack of defined inclusion criteria and a low specificity limits the application of this rule in practice. This article is protected by copyright. All rights reserved. PMID: 30311318 [PubMed - as supplied by publisher]
Source: Accident and Emergency Nursing - October 12, 2018 Category: Emergency Medicine Authors: Ohle R, Anjum O, Bleeker H, McIsaac S Tags: Acad Emerg Med Source Type: research

Early Outcomes After Branched and Fenestrated Endovascular Aortic Repair in Octogenarians.
CONCLUSIONS: Complex endovascular repair in octogenarians has higher early all cause mortality compared with non-octogenarians. Rupture and higher ASA class of ≥4 are independent predictors for early mortality. Age ≥80 years was found to be an independent predictor for higher early all cause mortality. PMID: 30241980 [PubMed - as supplied by publisher]
Source: PubMed: Eur J Vasc Endovasc ... - September 18, 2018 Category: Surgery Authors: Makaloski V, Kölbel T, Rohlffs F, Behrendt CA, Law Y, Debus ES, Tsilimparis N Tags: Eur J Vasc Endovasc Surg Source Type: research

Impact of Aortic Aneurysms in Trans-catheter Aortic Valve Replacement: A Single Center Experience
ConclusionsIn our patient cohort, 9.5% of patients who underwent TAVR had concomitant aortic aneurysms. Patients with aortic aneurysms had similar incidence of vascular complications as well as in-hospital and 6-month MACE compared to those without.
Source: Indian Heart Journal - July 10, 2018 Category: Cardiology Source Type: research

Alpha-2-antiplasmin Arg407Lys polymorphism and cryptogenic ischemic cerebrovascular events: Association with neurological deficit
ConclusionThe presence of 407Lys allele is associated with better prognosis in cryptogenic cerebrovascular events. Our findings suggest that the α2AP Arg407Lys polymorphism could be involved in the pathogenesis of cerebral ischemia and its outcomes.
Source: Polish Journal of Neurology and Neurosurgery - July 10, 2018 Category: Neurosurgery Source Type: research

Impact of Aortic Aneurysms in Trans-catheter Aortic Valve Replacement: A Single Center Experience
ConclusionsIn our patient cohort, 9.5% of patients who underwent TAVR had concomitant aortic aneurysms. Patients with aortic aneurysms had similar incidence of vascular complications as well as in-hospital and 6-month MACE compared to those without.
Source: Indian Heart Journal - July 10, 2018 Category: Cardiology Source Type: research

Alpha-2-antiplasmin Arg407Lys polymorphism and cryptogenic ischemic cerebrovascular events: Association with neurological deficit
ConclusionThe presence of 407Lys allele is associated with better prognosis in cryptogenic cerebrovascular events. Our findings suggest that the α2AP Arg407Lys polymorphism could be involved in the pathogenesis of cerebral ischemia and its outcomes.
Source: Polish Journal of Neurology and Neurosurgery - July 6, 2018 Category: Neurosurgery Source Type: research

Leptin, cardiovascular diseases and type 2 diabetes mellitus.
Abstract Leptin, an adipokine that is implicated in the control of food intake via appetite suppression, may also stimulate oxidative stress, inflammation, thrombosis, arterial stiffness, angiogenesis and atherogenesis. These leptin-induced effects may predispose to the development of cardiovascular diseases. In the present review we discuss the evidence linking leptin levels with the presence, severity and/or prognosis of both coronary artery disease and non-cardiac vascular diseases such as stroke, carotid artery disease, peripheral artery disease (PAD) and abdominal aortic aneurysms (AAA) as well as with chroni...
Source: Acta Pharmacologica Sinica - June 7, 2018 Category: Drugs & Pharmacology Authors: Katsiki N, Mikhailidis DP, Banach M Tags: Acta Pharmacol Sin Source Type: research

Gore wins expanded indications for Cardioform septal occluder
W.L. Gore & Associates said today it won expanded FDA indications for its Cardioform septal occluder, now cleared for the closure of patent foramen ovale to reduce the risk of recurrent ischemic stroke in certain patients. The expanded application was supported by results from the Reduce study, which the Newark, Del.-based company said showed that closure of PFOs could significantly prevent recurrent ischemic stroke regardless of PFO anatomy. “With the FDA approval of the Gore Cardioform septal occluder for PFO closure, we can now provide physicians with one device that can be used for both ASDs and PFOs. The val...
Source: Mass Device - April 3, 2018 Category: Medical Devices Authors: Fink Densford Tags: Cardiovascular Food & Drug Administration (FDA) Regulatory/Compliance W.L. Gore & Associates Source Type: news

Effectiveness of Screening Postmenopausal Women for Cardiovascular Diseases: A Population Based, Prospective Parallel Cohort Study.
CONCLUSIONS: This multifaceted screening offer to a general population sample of postmenopausal women had no effects on all cause mortality or hospital admission for MI, IHD, PAD, and stroke within a short-term follow up period. PMID: 29625727 [PubMed - as supplied by publisher]
Source: PubMed: Eur J Vasc Endovasc ... - April 3, 2018 Category: Surgery Authors: Dahl M, Søgaard R, Frost L, Høgh A, Lindholt J Tags: Eur J Vasc Endovasc Surg Source Type: research

EVAR for aortic abdominal aneurysms: A 20-year's experience of 1900  patients.
[EVAR for aortic abdominal aneurysms: A 20-year's experience of 1900 patients]. Presse Med. 2018 Mar 11;: Authors: Desgranges P, Kobeiter H, Cochennec F, Tacher V, Touma J, Majewski M, Marzelle J, Allaire É, Becquemin JP Abstract Abdominal aortic aneurysms (AAA), also called "silent killer" as they grow without symptoms until the final rupture, are the 3rd cause of cardiovascular deaths, after myocardial infarction and stroke. Surgery is the only efficient way of preventing aortic rupture. The initial technique, described by Charles Dubost in 1952 has evolved and results and provides fair long-term ...
Source: Presse Medicale - March 11, 2018 Category: General Medicine Authors: Desgranges P, Kobeiter H, Cochennec F, Tacher V, Touma J, Majewski M, Marzelle J, Allaire É, Becquemin JP Tags: Presse Med Source Type: research

Prevalence of Abdominal Aortic Aneurysms in the General Population and in Subgroups at High Cardiovascular Risk in Italy. Results of the RoCAV Population Based Study.
CONCLUSIONS: In the study population, both a general screening program in 65-75 year old men and an approach targeted to subgroups at higher risk merit evaluation in a cost-effectiveness study. In 50-64 year old men, strategies for population selection should consider CVD risk stratification tools. PMID: 29506942 [PubMed - as supplied by publisher]
Source: PubMed: Eur J Vasc Endovasc ... - March 2, 2018 Category: Surgery Authors: Gianfagna F, Veronesi G, Tozzi M, Tarallo A, Borchini R, Ferrario MM, Bertù L, Montonati A, Castelli P, RoCAV (Risk of Cardiovascular diseases and abdominal aortic Aneurysm in Varese) Project Investigators Tags: Eur J Vasc Endovasc Surg Source Type: research

Optimizing medical treatment of abdominal aortic aneurysm: Interest of vascular centers.
Abstract Diagnosis of abdominal aortic aneurysm (AAA) at preoperative stage is increasingly frequent. It carries both a local risk of rupture and an increased global cardiovascular risk. Patients with AAA have indeed a 20 times higher risk of dying from myocardial infarction or stroke than from a ruptured aneurysm. Cardiovascular risk factors control is therefore essential, particularly smoking cessation. Treatment in cardiovascular prevention is also warranted. Seeking for atheromatous sites is needed as they determine prognosis. Evidence of the benefit of medical treatment to slow AAA growth is still lacking. In...
Source: Presse Medicale - February 27, 2018 Category: General Medicine Authors: Madika AL, Mounier-Vehier C, Azzaoui R Tags: Presse Med Source Type: research

Unrecognized Cardiovascular Emergencies Among Medicare Patients
This cohort study estimates the proportions of emergency department visits attributable to symptoms of imminent ruptured abdominal aortic aneurysm, acute myocardial infarction, stroke, aortic dissection, and subarachnoid hemorrhage that end in discharge without diagnosis.
Source: JAMA Internal Medicine - February 26, 2018 Category: Internal Medicine Source Type: research

Cilostazol Attenuates Angiotensin II-Induced Abdominal Aortic Aneurysms but Not Atherosclerosis in Apolipoprotein E-Deficient Mice.
CONCLUSIONS: Cilostazol attenuated angiotensin II-induced AAA formation by its anti-inflammatory effect through phosphodiesterase III inhibition in the aortic wall. Cilostazol may be a promising new therapeutic option for AAAs. PMID: 29437572 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 8, 2018 Category: Cardiology Authors: Umebayashi R, Uchida HA, Kakio Y, Subramanian V, Daugherty A, Wada J Tags: Arterioscler Thromb Vasc Biol Source Type: research

Stroke volume variation and serum creatinine changes during abdominal aortic aneurysm surgery: a time-integrated analysis.
CONCLUSIONS: SVV increases progressively during and after AAA surgery in subjects who will develop AKI. The increase of SVV precedes and predicts the rise in sCr and is a good discriminator of the development of AKI. AKI is associated with an increased long-term risk for MACCE. PMID: 29344813 [PubMed - as supplied by publisher]
Source: Journal of Nephrology - January 17, 2018 Category: Urology & Nephrology Authors: Lentini P, Zanoli L, Fatuzzo P, Husain-Syed F, Stramanà R, Cognolato D, Catena V, Baiocchi M, Granata A, Dell'Aquila R Tags: J Nephrol Source Type: research

Alpha-2-antiplasmin Arg407Lys polymorphism and cryptogenic ischemic cerebrovascular events: Association with neurological deficit
Conclusion The presence of 407Lys allele is associated with better prognosis in cryptogenic cerebrovascular events. Our findings suggest that the α2AP Arg407Lys polymorphism could be involved in the pathogenesis of cerebral ischemia and its outcomes.
Source: Polish Journal of Neurology and Neurosurgery - December 26, 2017 Category: Neurosurgery Source Type: research

Alpha-2-antiplasmin Arg407Lys polymorphism and cryptogenic ischemic cerebrovascular events: Association with neurological deficit.
CONCLUSION: The presence of 407Lys allele is associated with better prognosis in cryptogenic cerebrovascular events. Our findings suggest that the α2AP Arg407Lys polymorphism could be involved in the pathogenesis of cerebral ischemia and its outcomes. PMID: 29306602 [PubMed - as supplied by publisher]
Source: Neurologia i Neurochirurgia Polska - December 26, 2017 Category: Neurology Authors: Wzorek J, Karpiński M, Wypasek E, Michalski M, Szczudlik A, Malinowski KP, Undas A Tags: Neurol Neurochir Pol Source Type: research

Medtronic launches pivotal trial of Intrepid TMVR system
Medtronic (NYSE:MDT) said today it launched a pivotal trial of its Intrepid transcatheter mitral valve replacement system after winning FDA investigational device exemption for the device. The 1st patient in the trial was enrolled at Milwaukee’s Aurora St. Luke’s Medical Center, the Fridley, Minn.-based company said. The Apollo trial is slated to enroll up to 1,200 patients with severe, symptomatic mitral valve regurgitation into 2 cohorts with a primary endpoint of composite of all-cause mortality, all-stroke, reoperation or reintervention and cardiovascular hospitalization at 1 year. Secondary endpoints in t...
Source: Mass Device - October 23, 2017 Category: Medical Devices Authors: Fink Densford Tags: Cardiac Implants Cardiovascular Catheters Clinical Trials Replacement Heart Valves Medtronic Source Type: news

Extended Serum Lipid Profile Predicting Long-Term Survival in Patients Treated for Abdominal Aortic Aneurysms
ConclusionsExtended serum lipid parameters complement risk prediction of patients treated for AAAs. An unfavourable lipid profile is associated with treatment of AAA earlier in life and with inferior long-term survival.
Source: World Journal of Surgery - October 12, 2017 Category: Surgery Source Type: research

Sex differences in vascular physiology and pathophysiology: estrogen and androgen signaling in health and disease
Sex differences between women and men are often overlooked and underappreciated when studying the cardiovascular system. It has been long assumed that men and women are physiologically similar, and this notion has resulted in women being clinically evaluated and treated for cardiovascular pathophysiological complications as men. Currently, there is increased recognition of fundamental sex differences in cardiovascular function, anatomy, cell signaling, and pathophysiology. The National Institutes of Health have enacted guidelines expressly to gain knowledge about ways the sexes differ in both normal function and diseases a...
Source: AJP: Heart and Circulatory Physiology - September 5, 2017 Category: Cardiology Authors: Boese, A. C., Kim, S. C., Yin, K.-J., Lee, J.-P., Hamblin, M. H. Tags: REVIEW Source Type: research

Adiponectin, lipids and atherosclerosis
Purpose of review: Adiponectin is an adipokine with anti-inflammatory, antioxidant, antiatherogenic, pro-angiogenic, vasoprotective and insulin-sensitizing properties. Several factors may influence adiponectin levels, such as genetic polymorphisms, obesity / body fat distribution, diet and exercise as well as cardiovascular risk factors such as sleep deprivation and smoking as well as medications. Adiponectin has been proposed as a potential prognostic biomarker and a therapeutic target in patients with cardiometabolic diseases. Recent findings: This narrative review discusses the associations of adiponectin with obesity-...
Source: Current Opinion in Lipidology - July 14, 2017 Category: Lipidology Tags: HYPERLIPIDAEMIA AND CARDIOVASCULAR DISEASE: Edited by Paul N. Durrington Source Type: research

Sex Differences in Vascular Physiology and Pathophysiology: Estrogen and Androgen Signaling in Health and Disease.
Abstract Sex differences between women and men are often overlooked and underappreciated when studying the cardiovascular system. It has been long assumed that men and women are physiologically similar, and this notion has resulted in females being clinically evaluated and treated for cardiovascular pathophysiological complications as males. Currently, there is increased recognition of fundamental sex differences in cardiovascular function, anatomy, cell signaling, and pathophysiology. NIH has enacted guidelines expressly to gain knowledge about ways the sexes differ in both normal function and diseases at the var...
Source: American Journal of Physiology. Heart and Circulatory Physiology - June 16, 2017 Category: Physiology Authors: Boese AC, Kim SC, Yin KJ, Lee JP, Hamblin MH Tags: Am J Physiol Heart Circ Physiol Source Type: research

Endovascular treatment for ruptured abdominal aortic aneurysm.
CONCLUSIONS: The conclusions of this review are currently limited by the paucity of data. We found from the data available moderate-quality evidence suggesting there is no difference in 30-day mortality between eEVAR and open repair. Not enough information was provided for complications for us to make a well-informed conclusion, although it is possible that eEVAR is associated with a reduction in bowel ischaemia. Long-term data were lacking for both survival and late complications. More high-quality randomised controlled trials comparing eEVAR and open repair for the treatment of RAAA are needed to better understand if one...
Source: Cochrane Database of Systematic Reviews - May 26, 2017 Category: General Medicine Authors: Badger S, Forster R, Blair PH, Ellis P, Kee F, Harkin DW Tags: Cochrane Database Syst Rev Source Type: research

Optimal vs Feasible Volume Thresholds in Vascular Surgery
The volume-outcome relationship in vascular surgery has been an especially controversial topic recently, given the declining trainee exposure to complex open vascular cases, additional series reporting improved outcomes with higher volume, and medical organizations, such as Leapfrog, recommending volume thresholds for certain procedures. However, the definition of volume and the delineation of a specific threshold number of cases below which surgeons should not be credentialed remain unclear. In this issue ofJAMA Surgery, Mao et al took a unique approach to looking at outcomes among the very lowest-volume surgeons —those...
Source: JAMA Surgery - May 17, 2017 Category: Sports Medicine Source Type: research

Deriving literature-based benchmarks for surgical complications in high-income countries: a protocol for a systematic review and meta-analysis
This study of secondary data does not require ethics approval. It will be presented internationally and published in the peer-reviewed literature. Results will inform a future quality improvement tool and provide benchmarks of surgical complication rates within HICs. Trial registration International Prospective Register of Systematic Reviews (PROSPERO). Registration number CRD42016037519.
Source: BMJ Open - May 9, 2017 Category: General Medicine Authors: Brindle, M. E., Roberts, D. J., Daodu, O., Haynes, A. B., Cauley, C., Dixon, E., La Flamme, C., Bain, P., Berry, W. Tags: Open access, Health policy Protocol Source Type: research

Retrospective analysis of Spinal Cord Infarction after Aortic Repair (P6.300)
Conclusions:The rate of spinal cord infarction after aortic repair is low overall, but is higher after repair of a ruptured aortic aneurysm or dissection.Study Supported by:Dr. Gialdini is supported by the Feil Family Foundation.Dr. Kamel is supported by NIH grants K23NS082367 and R01NS097443 as well as the Michael Goldberg Research Fund.Disclosure: Dr. Gialdini has nothing to disclose. Dr. Merkler has nothing to disclose. Dr. Parikh has nothing to disclose. Dr. Lerario has nothing to disclose. Dr. Chatterjee has nothing to disclose. Dr. Kamel has received personal compensation for activities with Genentech as a speaker. D...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Gialdini, G., Merkler, A., Parikh, N., Lerario, M., Chatterjee, A., Kamel, H. Tags: Cardiovascular Issues in Ischemic Stroke Source Type: research

Moderate drinking may reduce heart disease risk
Conclusion This study paints a more complicated picture than the "Pint a day keeps the doctor away" story proffered by The Sun. It seems to confirm the findings of other studies, which have shown that non-drinkers tend to have a higher risk of cardiovascular diseases than people who drink moderately. It suggests that some cardiovascular diseases (mainly those directly affecting the heart) seem to have a stronger link to a possible protective effect from alcohol than other vascular diseases, such as mini-strokes and bleeding in the brain. However, this can't be concluded with certainty due to the study design. We ...
Source: NHS News Feed - March 23, 2017 Category: Consumer Health News Tags: Heart/lungs Food/diet Lifestyle/exercise Source Type: news

Homocysteine and non-cardiac vascular disease.
Abstract Elevated homocysteine (Hcy) levels are predictors of cardiovascular disease (CVD). Hyperhomocysteinemia has also been associated with total and CVD mortality. However, whether Hcy is just a marker or plays a causal role in CVD remains to be elucidated. In this narrative review, we discuss the associations between Hcy and non-cardiac vascular diseases, namely stroke, peripheral artery disease (PAD), carotid artery disease, chronic kidney disease (CKD), atherosclerotic renal artery stenosis (ARAS), abdominal aortic aneurysm (AAA) and erectile dysfunction (ED). The effects of several drugs on Hcy levels are ...
Source: Current Pharmaceutical Design - March 17, 2017 Category: Drugs & Pharmacology Authors: Katsiki N, Perez-Martinez P, Mikhailidis DP Tags: Curr Pharm Des Source Type: research

Intra-hospital correlations among 30-day mortality rates in 18 different clinical and surgical settings
Conclusions</div>The variability in 30-day mortality rates at hospital level and the correlation between risk mortality rates suggest that there may be common hospital-wide factors influencing short-term mortality.</span>
Source: International Journal for Quality in Health Care - February 1, 2017 Category: Global & Universal Source Type: research

Single-center mid-term experience with chimney-graft technique for the preservation of flow to the supra-aortic branches.
Conclusions The chimney-graft technique, despite a technically demanding strategy, is a useful tool as bailout procedure in our armamentarium for high-risk patients, unsuitable for open or hybrid repair. PMID: 29022854 [PubMed - as supplied by publisher]
Source: Vascular - January 1, 2017 Category: Surgery Authors: Shahverdyan R, Mylonas S, Gawenda M, Brunkwall J Tags: Vascular Source Type: research

Protocol for Evaluating the Cardio-Ankle Vascular Index to Predict Cardiovascular Events in Japan: A Prospective Multicenter Cohort Study
The objective of this study was to examine the benefits of using CAVI as a predictor of cardiovascular events in high-risk patients.Methods and Design: This prospective multicenter study to evaluate the usefulness of the CAVI to predict cardiovascular events in Japan (CAVI-J) is a cohort study with central registration. Participants (n = 3,000) will be scheduled to enroll and data will be collected for up to 5 years from entry of participants into the study. To be eligible to participate in the CAVI-J study, individuals have to be aged between 40 and 74 years and have at least one of the following risk factors for arterios...
Source: Pulse - December 22, 2016 Category: Cardiology Source Type: research

MassDevice.com +5 | The top 5 medtech stories for December 6, 2016
Say hello to MassDevice +5, a bite-sized view of the top five medtech stories of the day. This feature of MassDevice.com’s coverage highlights our 5 biggest and most influential stories from the day’s news to make sure you’re up to date on the headlines that continue to shape the medical device industry. Get this in your inbox everyday by subscribing to our newsletters.   5. MedyMatch looks to future of stroke detection with AI platform launch Artificial intelligence healthcare startup MedyMatch Technology said late last month its AI platform designed to detect intracranial hemorrhage or brain blee...
Source: Mass Device - December 6, 2016 Category: Medical Equipment Authors: MassDevice Tags: News Well Plus 5 Source Type: news

Causes of Death in an Acute Psychiatric Inpatient Unit of a Portuguese General Hospital.
CONCLUSION: Mortality studies are important for determining quality of health care and to create recommendations for preventive measures. PMID: 27914158 [PubMed - in process]
Source: Acta Medica Portuguesa - December 5, 2016 Category: Journals (General) Tags: Acta Med Port Source Type: research

MassDevice.com +5 | The top 5 medtech stories for November 16, 2016
Say hello to MassDevice +5, a bite-sized view of the top five medtech stories of the day. This feature of MassDevice.com’s coverage highlights our 5 biggest and most influential stories from the day’s news to make sure you’re up to date on the headlines that continue to shape the medical device industry. Get this in your inbox everyday by subscribing to our newsletters.   5. St. Jude Medical’s HeartMate 3 implantable pump beats HeartMate II in pivotal trial The next-generation HeartMate 3 implantable pump St. Jude Medical acquired when it paid $3 billion for Thoratec last year proved superior to ...
Source: Mass Device - November 16, 2016 Category: Medical Equipment Authors: MassDevice Tags: News Well Plus 5 Source Type: news

Operative and Midterm Outcomes of the Fenestrated Anaconda Stent-Graft in the Endovascular Treatment of Juxtarenal, Suprarenal, and Type IV Thoracoabdominal Aortic Aneurysms
Conclusion: FEVAR with the Anaconda device delivers satisfactory short-term technical and clinical success rates in patients with juxtarenal, suprarenal, and type IV TAAA. Midterm efficacy and durability with respect to aneurysm sac regression and target vessel patency appear very good. Overall mortality and the need for reintervention were significant in this patient cohort.
Source: Journal of Endovascular Therapy - November 6, 2016 Category: Surgery Authors: Kotelis, D., Schleimer, K., Foldenauer, C., Jalaie, H., Grommes, J., Jacobs, M. J., Kalder, J. Tags: Endovascular Aneurysm Repair Source Type: research

The Endovascular Sealing Device in Combination with Parallel Grafts for Treatment of Juxta/Suprarenal Abdominal Aortic Aneurysms: Short-term Results of a Novel Alternative.
CONCLUSIONS: Ch-EVAS appears to offer a feasible solution for juxtarenal and suprarenal aneurysms with adverse morphology. In this short-term follow-up endoleak rates were low and re-intervention rates were acceptable. Outcomes over extended follow-up will determine the application of this novel technique and better define which patients and aneurysm morphology can be treated effectively. PMID: 27527570 [PubMed - as supplied by publisher]
Source: PubMed: Eur J Vasc Endovasc ... - August 12, 2016 Category: Surgery Authors: De Bruin JL, Brownrigg JR, Patterson BO, Karthikesalingam A, Holt PJ, Hinchliffe RJ, Loftus IM, Thompson MM Tags: Eur J Vasc Endovasc Surg Source Type: research

Shared Genetic Risk Factors of Intracranial, Abdominal, and Thoracic Aneurysms Genetics
Conclusions Although there was no evidence for polygenic overlap between IAs, AAAs, and TAAs, we found nominally significant effects of two established risk loci for IAs and TAAs in AAAs. These two loci will require further replication.
Source: JAHA:Journal of the American Heart Association - July 14, 2016 Category: Cardiology Authors: van t Hof, F. N. G., Ruigrok, Y. M., Lee, C. H., Ripke, S., Anderson, G., de Andrade, M., Baas, A. F., Blankensteijn, J. D., Böttinger, E. P., Bown, M. J., Broderick, J., Bijlenga, P., Carrell, D. S., Crawford, D. C., Crosslin, D. R., Ebeling, C., Tags: Inflammation, Vascular Biology, Ischemic Stroke Genetics Source Type: research

Risk factors associated with increased prevalence of abdominal aortic aneurysm in women
ConclusionThis report should stimulate consideration of a targeted AAA screening programme for women aged over 65 years.
Source: British Journal of Surgery - June 23, 2016 Category: Surgery Authors: M. Chabok, A. Nicolaides, M. Aslam, M. Farahmandfar, K. Humphries, N. Z. Kermani, J. Coltart, N. Standfield Tags: Original article Source Type: research

Prevalence of Abdominal Aortic Aneurysm in Men Aged 65-74 Years in a Metropolitan Area in North-East Spain.
CONCLUSIONS: The current screening prevalence of AAA among men aged 65-74 years in a metropolitan area in north-east Spain is similar to that in northern Europe. Smoking, myocardial infarction, and height were associated with the presence of AAA. PMID: 27252078 [PubMed - as supplied by publisher]
Source: PubMed: Eur J Vasc Endovasc ... - May 29, 2016 Category: Surgery Authors: Salvador-González B, Martín-Baranera M, Borque-Ortega Á, Sáez-Sáez RM, de Albert-Delas Vigo M, Carreño-García E, Tarín-Masriera L, Badia-Millán P, Martínez-Gil M, Torrabadella-Fàbrega J Tags: Eur J Vasc Endovasc Surg Source Type: research

What Should the Optimal Systolic Blood Pressure Goal Be in Treating Older Persons with Hypertension?
Hypertension is a major risk factor for cardiovascular disease in the elderly.1 Hypertension occurs in 69% of persons with a first myocardial infarction,2 in 77% of those with a first stroke,2 in 74% of individuals with congestive heart failure,2 and in 60% of older adults with peripheral artery disease.3 Hypertension is also a major risk factor in older adults for dissecting aortic aneurysm, sudden cardiac death, angina pectoris, chronic kidney disease, left ventricular hypertrophy, thoracic and abdominal aortic aneurysms, atrial fibrillation, diabetes mellitus, the metabolic syndrome, vascular dementia, Alzheimer disease...
Source: Journal of the American Medical Directors Association - May 20, 2016 Category: Health Management Authors: Wilbert S. Aronow Tags: Editorial Source Type: research

Androgen receptor (AR) in cardiovascular diseases
Cardiovascular diseases (CVDs) are still the highest leading cause of death worldwide. Several risk factors have been linked to CVDs, including smoking, diabetes, hyperlipidemia, and gender among others. Sex hormones, especially the androgen and its receptor, androgen receptor (AR), have been linked to many diseases with a clear gender difference. Here, we summarize the effects of androgen/AR on CVDs, including hypertension, stroke, atherosclerosis, abdominal aortic aneurysm (AAA), myocardial hypertrophy, and heart failure, as well as the metabolic syndrome/diabetes and their impacts on CVDs. Androgen/AR signaling exacerba...
Source: Journal of Endocrinology - April 29, 2016 Category: Endocrinology Authors: Huang, C.-K., Lee, S. O., Chang, E., Pang, H., Chang, C. Tags: Review Source Type: research

This Week in Cardiology: Advances in Stroke, Heart Medicine
(MedPage Today) -- Two installments of Hot Topics will feature predictions about the big developments expected in stroke and cardiovascular medicine. And guidelines will be in the headlines again, this time for abdominal aortic aneurysm.
Source: MedPage Today Cardiovascular - January 27, 2014 Category: Cardiology Source Type: news