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Total 970 results found since Jan 2013.

Monoclonal antibody as an emerging therapy for acute ischemic stroke.
Authors: Woods D, Jiang Q, Chu XP Abstract Acute ischemic stroke (AIS) is the 5th leading cause of death and the leading cause of neurological disability in the United States. The oxygen and glucose deprivation associated with AIS not only leads to neuronal cell death, but also increases the inflammatory response, therefore decreasing the functional outcome of the brain. The only pharmacological intervention approved by the US Federal Food and Drug Administration for treatment of AIS is tissue plasminogen activator (t-PA), however, such treatment can only be given within 4.5 hours of the onset of stroke-like sympto...
Source: International Journal of Physiology, Pathophysiology and Pharmacology - September 18, 2020 Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research

Electroacupuncture Attenuates Inflammation after Ischemic Stroke by Inhibiting NF- κB-Mediated Activation of Microglia.
In this study, we observed the effects of electroacupuncture at Baihui (GV20) and Dazhui (GV14) on microglial activation and inflammation in the cortical ischemic penumbra (IP) of permanent middle cerebral artery occlusion (pMCAO) rats. It was found that electroacupuncture inhibited the degeneration and necrosis of microglia in the cortical IP and ameliorated mitochondrial damage. Immunofluorescence and western blot analysis showed that microglia were in a resting state or weakly activated in the normal brain. After cerebral ischemia, the expression of microglial markers (Iba-1 and CD11b) increased, and NF-κB p65, IL-1β,...
Source: Evidence-based Complementary and Alternative Medicine - September 15, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Iso-Oncotic Albumin Mitigates Brain and Kidney Injury in Experimental Focal Ischemic Stroke
Conclusions: In this model of focal ischemic stroke, only iso-oncotic albumin had a protective effect against brain and kidney damage. Fluid therapy thus requires careful analysis of impact not only on the brain but also on the kidney.
Source: Frontiers in Neurology - September 2, 2020 Category: Neurology Source Type: research

The resolution of carotid arterial thrombus by oral anticoagulation after IV thrombolysis for chemotherapy-induced stroke: A case report
Rationale: Cancer-related stroke has been regarded as an emerging subtype of ischemic event. Acute treatment for this subtype may include the antiplatelet agents, anticoagulants, or endovascular intervention. Patient concerns: A 63-year-old woman with sudden-onset right hemiparesis and conscious change was sent to our emergency department. The patient had underlying sigmoid adenocarcinoma and received chemotherapy FOLFIRI (FOL, folinic acid; F, fluorouracil; and IRI, irinotecan) with targeted therapy cetuximab following lower anterior resection since the diagnosis was made. Diagnoses: Brain magnetic resonance angio...
Source: Medicine - August 28, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

An Autopsy Case of Lambl's Excrescences with Trousseau Syndrome that Caused Cardioembolic Stroke.
Authors: Hirayama T, Morioka H, Fujiwara H, Iwamoto K, Kiyozuka T, Takeo H, Ikeda K, Kano O Abstract The frequency and risk of embolism by Lambl's excrescences (LEs) remain unclear. We herein report an autopsy case of LEs that caused cardioembolic stroke. A 74-year-old man with colon cancer was hospitalized for ischemic stroke. His D-dimer levels were elevated. Thus, a diagnosis of ischemic stroke with Trousseau syndrome was made. At the autopsy, we found LEs in the aortic valves and thromboembolism of the brain blood vessels. This finding demonstrated that fibrin clots had adhered to the LEs because of coagulation...
Source: Internal Medicine - August 14, 2020 Category: Internal Medicine Tags: Intern Med Source Type: research

Stroke-like migraine attacks after radiation therapy (SMART) syndrome —a case series and review
ConclusionOur extensive review favors MRI, CT, and prolonged EEG monitoring to rule out other differentials and showed that initiation of corticosteroid therapy and antiepileptic treatment were helpful in the resolution of symptoms and prevent recurrences. Therefore, future studies should be focused on early identification and management guidelines for SMART syndrome.
Source: Neurological Sciences - July 12, 2020 Category: Neurology Source Type: research

Upregulating microRNA-874-3p inhibits CXCL12 expression to promote angiogenesis and suppress inflammatory response in ischemic stroke.
Abstract Identification of specific biomarkers for ischemic stroke is necessary due to their abilities to improve treatment outcomes. Many studies have demonstrated the involvement of microRNAs (miRNAs) in the pathogenesis and complications of ischemic stroke and patient outcomes. We found that the expression of miR-874-3p was downregulated in clinical samples of ischemic stroke. Thus, the present study explored the potential role of miR-874-3p in ischemic stroke and related mechanisms. A mouse model of ischemic stroke was constructed by middle cerebral artery occlusion. The relationship among miR-874-3p, C-X-C mo...
Source: Am J Physiol Cell Ph... - June 30, 2020 Category: Cytology Authors: Xie K, Cai Y, Yang P, Du F, Wu K Tags: Am J Physiol Cell Physiol Source Type: research

Polyoxometalate nanoclusters act as broad-spectrum antioxidants to alleviate ischemic stroke by intrathecal injection
Conclusion: Intrathecal injection significantly improved the delivery and efficacy of POM nanoclusters to the brain, resulting in the rapid accumulation of POM nanoclusters in the ischemic penumbra. Due to this, we confirmed that the POM nanoclusters could be used as nano-antioxidants to inhibit oxidative stress as well as inflammatory damage effectively.
Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Rosenkrans, Z., Li, S., Jiang, D., NI, D., Engle, J., Cai, W. Tags: Center for Molecular Imaging Innovation & amp; Translation (CMIIT) YIA Symposium Source Type: research

Cardiac Myxoma as a Rare Cause of Pediatric Arterial Ischemic Stroke: Case Report and Literature Review
Conclusion Neurological presentation of AIS due to cardiac myxoma is similar to that of AIS with other etiologies, although clues suggesting a possible underlying cardiac myxoma can be detected in most cases. A timely diagnosis of cardiac myxoma in patients with AIS may favor prompt identification of candidates for endovascular therapy. Therefore, we suggest that in otherwise-healthy children presenting with AIS, transthoracic echocardiography should be performed early after stroke presentation. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Neuropediatrics - May 4, 2020 Category: Neurology Authors: Tona, Clarissa Nosadini, Margherita Pelizza, Maria F. Pin, Jacopo N. Baggio, Laura Boniver, Clementina Gabrieli, Joseph D. Causin, Francesco Toldo, Irene Sartori, Stefano Tags: Review Article Source Type: research

Tissue Plasminogen Activator Promotes TXNIP-NLRP3 Inflammasome Activation after Hyperglycemic Stroke in Mice
AbstractHyperglycemia has been shown to counterbalance the beneficial effects of tissue plasminogen activator (tPA) and increase the risk of intracerebral hemorrhage in ischemic stroke. Thioredoxin interacting protein (TXNIP) mediates hyperglycemia-induced oxidative damage and inflammation in the brain and reduces cerebral glucose uptake/utilization. We have recently reported that TXNIP-induced NLRP3 (NOD-like receptor pyrin domain-containing-3) inflammasome activation contributes to neuronal damage after ischemic stroke. Here, we tested the hypothesis that tPA induces TXNIP-NLRP3 inflammasome activation after ischemic str...
Source: Molecular Neurobiology - March 13, 2020 Category: Neurology Source Type: research

Human neural stem cells improve early stage stroke outcome in delayed tissue plasminogen activator-treated aged stroke brains.
CONCLUSIONS: Aged stroke mice that received delayed tPA treatment in combination with hNSC transplantation exhibited reduced stroke pathophysiology in comparison to non-transplanted stroke mice with delayed tPA. This suggests that hNSC transplantation may synergize with already existing stroke therapies to benefit a larger stroke patient population. PMID: 32147438 [PubMed - as supplied by publisher]
Source: Experimental Neurology - March 4, 2020 Category: Neurology Authors: Boese A, Eckert A, Hamblin MH, Lee JP Tags: Exp Neurol Source Type: research

Stroke: Macrophages migrate from the blood
(University of Bonn) Macrophages are part of the innate immune system and essential for brain development and function. Using a novel method, scientists from Jena University Hospital, the University of Bonn and the Memorial Sloan Kettering Cancer Center (USA) succeeded in visualizing macrophages that were formed in the bone marrow. This technology enabled to observe that shortly after a stroke, numerous macrophages that had migrated from the blood begin to attack dead and adjacent healthy brain tissue.
Source: EurekAlert! - Medicine and Health - February 11, 2020 Category: International Medicine & Public Health Source Type: news

An Embolic Stroke in a Patient With PROC p.Lys193del
We report a 58-year-old woman who suddenly developed brain infarction with weakness of the left lower extremity and left perioral dysesthesia during postoperative tamoxifen therapy for breast cancer and prednisolone therapy for rheumatoid arthritis. Diffusion-weighted images detected multiple areas of hyperintensity in the posterior circulation system of the brain. Despite extensive examinations, we could not identify any embolic sources except hypoplasia of the right vertebral artery. We found decreased activity of protein C against its antigen level (activity: 59% versus antigen: 122%) with enhanced activity of coagulati...
Source: Journal of Stroke and Cerebrovascular Diseases - February 10, 2020 Category: Neurology Authors: Kana Ueki, Kuniyuki Nakamura, Yoshinobu Wakisaka, Shinichi Wada, Yoji Yoshikawa, Shinya Matsumoto, Taeko Hotta, Dongchong Kang, Takanari Kitazono, Tetsuro Ago Tags: Case Report Source Type: research

The protective effect of polyethylene glycol-conjugated urokinase nanogels in rat models of ischemic stroke when administrated outside the usual time window.
In conclusion, through the inhibition of LRP/NF-κB/Cox-2 pathway, the Caspase cascade and activation of NMDARs, administration of PEG-UK outside the usual time window could still exert protective effects in pMCAO rats through the maintenance of the integrity of BBB and the inhibition of apoptosis and excito-neurotoxicity. PMID: 31955887 [PubMed - as supplied by publisher]
Source: Biochemical and Biophysical Research communications - January 15, 2020 Category: Biochemistry Authors: Cui W, Liu R, Jin H, Huang Y, Liu W, He M Tags: Biochem Biophys Res Commun Source Type: research

Calycosin Preserves BDNF/TrkB Signaling and Reduces Post-Stroke Neurological Injury after Cerebral Ischemia by Reducing Accumulation of Hypertrophic and TNF- α-Containing Microglia in Rats
This study was a prospective, randomized, blinded and placebo-controlled preclinical experiment. Sprague-Dawley adult rats, subjected to transient focal cerebral ischemia by middle cerebral artery occlusion (MCAO), were treated randomly with 0 (corn oil and/or saline as placebo), 30  mg/kg of Calycosin and/or 1 mg/kg of a tropomyosin-related kinase B (TrkB) receptor antagonist (ANA12) at 1 h after reperfusion and once daily for a total of 7 consecutive days. BDNF and its functional receptor, full-length TrkB (TrkB-FL) levels, the percentage of hypertrophic microglia, tumor n ecrosis factor-α (TNF-α)-containing microgl...
Source: Journal of NeuroImmune Pharmacology - January 10, 2020 Category: Drugs & Pharmacology Source Type: research

Pharmacological hypothermia induced neurovascular protection after severe stroke of transient middle cerebral artery occlusion in mice.
Abstract Therapeutic hypothermia is a potential protective strategy after stroke. The present study evaluated the neurovascular protective potential of pharmacological hypothermia induced by the neurotensin receptor 1 agonist HPI-201 after severe ischemic stroke. Adult C57BL/6 mice were subjected to filament insertion-induced occlusion of the middle cerebral artery (60 min MCAO). HPI-201 was i.p. injected 120 min after the onset of MCAO to initiate and maintain the body temperature at 32-33°C for 6 hrs. The infarct volume, cell death, integrity of the blood brain barrier (BBB) and neurovascular unit (NVU), inflam...
Source: Experimental Neurology - November 22, 2019 Category: Neurology Authors: Zhao Y, Wei ZZ, Lee JH, Gu X, Sun J, Dix TA, Wei L, Yu SP Tags: Exp Neurol Source Type: research

Ischemic stroke caused by giant cell arteritis associated with pulmonary adenocarcinoma
We describe a 77-year-old man with a sudden onset of dizziness, vomiting, and gait disturbances. Following imaging studies, a diagnosis of bulbar ischemic stroke with left vertebral artery stenosis was made. Based on a history of polymyalgia rheumatica, on laboratory tests, and brain digital subtraction angiography, a diagnosis of GCA was advanced and the patient underwent high-dose steroidal therapy. After a total body 18-FGD PET imaging, a pulmonary adenocarcinoma was found.Vertebral artery involvement is a rare but important occurrence in GCA as it carries a high mortality rate, and may require a vigorous therapeutic ap...
Source: Journal of Clinical Neuroscience - November 5, 2019 Category: Neuroscience Source Type: research

Chungkookjang, a soy food, fermented with Bacillus amyloliquefaciens protects gerbils against ishcmeic stroke injury, and post-stroke hyperglycemia
In conclusion, the daily intake of chungkookjang fermented with B. amyloliquefaciens improved the gut microbiome, increased blood flow to the brain, suppressed systemic inflammation, and may reduce the susceptibility to injury from ischemic stroke in gerbils subjected to ischemic injury.Graphical abstract
Source: Food Research International - October 31, 2019 Category: Food Science Source Type: research

“Accent issue”: foreign accent syndrome following ischemic stroke
In conclusion, FAS is a rare motor speech disorder, often related to cerebrovascular accidents involving critical regions in the dominant hemisphere. In addition, the present case adds further evidence to the role of the left primary motor cortex in modulation of prosody. In rare cases FAS can be the only sign of stroke or can appear after recovery from post-stroke aphasia.
Source: Neurological Sciences - October 28, 2019 Category: Neurology Source Type: research

Mediterranean diet: The role of long-chain ω-3 fatty acids in fish; polyphenols in fruits, vegetables, cereals, coffee, tea, cacao and wine; probiotics and vitamins in prevention of stroke, age-related cognitive decline, and Alzheimer disease.
Authors: Román GC, Jackson RE, Gadhia R, Román AN, Reis J Abstract The mechanisms of action of the dietary components of the Mediterranean diet are reviewed in prevention of cardiovascular disease, stroke, age-associated cognitive decline and Alzheimer disease. A companion article provides a comprehensive review of extra-virgin olive oil. The benefits of consumption of long-chain ω-3 fatty acids are described. Fresh fish provides eicosapentaenoic acid while α-linolenic acid is found in canola and soybean oils, purslane and nuts. These ω-3 fatty acids interact metabolically with ω-6 fatty acids mainly linoleic...
Source: Revue Neurologique - September 16, 2019 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Stroke-Like Presentation of Paraneoplastic Cerebellar Degeneration: a Single-Center Experience and Review of the Literature.
We report herein incidence and clinical features of hyperacute onset PCD, a vertebrobasilar stroke mimic. We performed a retrospective analysis of all suspected PCD cases referred to the Udine University Hospital between 2009 and 2017. Our center provides the only neuroimmunology laboratory for three provinces of the Friuli-Venezia Giulia region, Italy (983,190 people as of January 1, 2017). Inclusion criteria were (1) abrupt onset of neurological symptoms; (2) initial consideration of a vascular etiology; (3) final diagnosis of "definite PCD." We also carried out a systematic review of the literature in order to identify ...
Source: Cerebellum - August 28, 2019 Category: Neuroscience Authors: Vogrig A, Bernardini A, Gigli GL, Corazza E, Marini A, Segatti S, Fabris M, Honnorat J, Valente M Tags: Cerebellum Source Type: research

Stroke-Like Presentation of Paraneoplastic Cerebellar Degeneration: a Single-Center Experience and Review of the Literature
We report herein incidence and clinical features of hyperacute onset PCD, a vertebrobasilar stroke mimic. We performed a retrospective analysis of all suspected PCD cases referred to the Udine University Hospital between 2009 and 2017. Our center provides the only neuroimmunology laboratory for three provinces of the Friuli-Venezia Giulia region, Italy (983,190 people as of January 1, 2017). Inclusion criteria were (1) abrupt onset of neurological symptoms; (2) initial consideration of a vascular etiology; (3) final diagnosis of “definite PCD.” We also carried out a systematic review of the literature in order to ident...
Source: The Cerebellum - August 28, 2019 Category: Neurology Source Type: research

Neutrophil ‐to‐lymphocyte ratio predicts hemorrhagic transformation in ischemic stroke: A meta‐analysis
ConclusionA high NLR can predict HT and 3 ‐month mortality in patients with AIS. Regardless of the country of origin and the sampling time, an NLR with a cutoff value of 7.5–11 was independently associated with HT in AIS patients.
Source: Brain and Behavior - August 19, 2019 Category: Neurology Authors: Ruirui Zhang, Xiaodong Wu, Wenjie Hu, Li Zhao, Shoucai Zhao, Ji Zhang, Zhaohu Chu, Yang Xu Tags: ORIGINAL RESEARCH Source Type: research

The importance of selected markers of inflammation and blood-brain barrier damage for short-term ischemic stroke prognosis.
Authors: Lasek-Bal A, Jedrzejowska-Szypulka H, Student S, Warsz-Wianecka A, Zareba K, Puz P, Bal W, Pawletko K, Lewin-Kowalik J Abstract Acute cerebral ischemia triggers local and systemic immune response. The aims of this project was to assess the blood serum concentration of the markers of inflammation and markers of the blood brain barrier damage on the first day of ischemic stroke, and the mutual correlations between these marker levels. Patients with first-in-life stroke were analysed according to: plasma concentration of the following markers on the first day of stroke: interleukin 2 (IL-2) and interleuki 6 (...
Source: Journal of Physiology and Pharmacology - July 31, 2019 Category: Drugs & Pharmacology Tags: J Physiol Pharmacol Source Type: research

Aerobic Training Efficacy in Inflammation, Neurotrophins, and Function in Chronic Stroke Persons: A Randomized Controlled Trial Protocol
Background: Neuroinflammation is an important part of stroke pathophysiology and has both detrimental and beneficial effects after stroke. Besides that the enhancement of neurotrophins seems to be related to improvements in stroke recovery. Evidences suggest that exercise plays a role in modulating anti-inflammatory and neurotrophic effects. However, little is known about its impact in stroke survivors, mainly in chronic stroke. The purpose of this study is to investigate the efficacy of moderate-intensity treadmill exercise in changing inflammatory mediators, interleukin-6 (IL-6), soluble tumor necrosis factor receptors I...
Source: Journal of Stroke and Cerebrovascular Diseases - November 10, 2018 Category: Neurology Authors: Daniela Matos Garcia Oliveira, Larissa Tavares Aguiar, Marcus Vin ícius de Oliveira Limones, Aline Gonçalves Gomes, Luana Cristina da Silva, Christina Danielli Coelho de Morais Faria, Paula Luciana Scalzo Source Type: research

Brain-Derived Neurotrophic Factor Levels are Lower in Chronic Stroke Patients: A Relation with Manganese-dependent Superoxide Dismutase ALA16VAL Single Nucleotide Polymorphism through Tumor Necrosis Factor- α and Caspases Pathways
The manganese-dependent superoxide dismutase (MnSOD) Ala16Val single nucleotide polymorphism (SNP) has shown to be associated to risk factors of vascular diseases. Brain-Derived Neurotrophic Factor (BDNF) plays an essential role in the plasticity and neuronal regeneration of the brain after vascular injuries. However, little is known about interaction between MnSOD Ala16Val SNP on stroke, a frequent neurologic disease that involves various interacting pathways, such as vascular dysfunctions, inflammation, and neurotrophic factors.
Source: Journal of Stroke and Cerebrovascular Diseases - August 25, 2018 Category: Neurology Authors: Mr. Eduardo Tanuri Pascotini, Dr. Ariane Ethur Flores, Mrs. Aline Kegler, Mrs. Vivana Konzen, Mrs. Ana Let ícia Fornari, Mrs. Josi Arend, Mrs. Patricia Gabbi, Mrs. Luciana Assis Gobo, Dr. Guilherme Vargas Bochi, Dr. Ana Lucia Cervi Prado, Dr. Leandro Mac Source Type: research

Association of Cancer Cell Type and Extracellular Vesicles With Coagulopathy in Patients With Lung Cancer and Stroke Brief Report
Conclusions—Our findings indicate that cancer cell type is associated with circulating EV levels and coagulopathy in patients with lung cancer and stroke.
Source: Stroke - April 23, 2018 Category: Neurology Authors: Jong-Won Chung, Yeon Hee Cho, Myung-Ju Ahn, Mi Ji Lee, Gyeong-Moon Kim, Chin-Sang Chung, Oh Young Bang Tags: Biomarkers, Mechanisms, Translational Studies, Cerebrovascular Disease/Stroke, Thrombosis Brief Reports Source Type: research

Lacunar Stroke, Cavernous Angioma, and Fusiform Aneurysm Due to Irradiation for Pilocytic Astrocytoma —A Case Report
We describe a rare case of a pediatric patient who presented multiple different types of vascular events consecutively in the irradiated field including lacunar stroke because of occlusion of perforating artery, intraventricular hemorrhage from cavernoma, and subarachnoid hemorrhage because of the rupture of fusiform aneurysm, 6 years after radiotherapy against pilocytic astrocytoma.
Source: Journal of Stroke and Cerebrovascular Diseases - April 16, 2018 Category: Neurology Authors: Maruyama Kunitaka, Takuya Akai, Naoki Akioka, Takahiro Tomita, Shoichi Nagai, Satoshi Kuroda Tags: Case Studies Source Type: research

Long Noncoding RNA H19 Promotes Neuroinflammation in Ischemic Stroke by Driving Histone Deacetylase 1-Dependent M1 Microglial Polarization Basic Sciences
Conclusions—Our findings indicate that H19 promotes neuroinflammation by driving HDAC1-dependent M1 microglial polarization, suggesting a novel H19-based diagnosis and therapy for ischemic stroke.
Source: Stroke - July 24, 2017 Category: Neurology Authors: Jue Wang, Haiping Zhao, Zhibin Fan, Guangwen Li, Qingfeng Ma, Zhen Tao, Rongliang Wang, Juan Feng, Yumin Luo Tags: Animal Models of Human Disease, Cerebrovascular Disease/Stroke, Ischemic Stroke Original Contributions Source Type: research

MicroRNA-15a/16-1 Antagomir Ameliorates Ischemic Brain Injury in Experimental Stroke Basic Sciences
Conclusions—Our data indicate that pharmacological inhibition of the miR-15a/16-1 cluster reduces ischemic brain injury via both upregulation of antiapoptotic proteins and suppression of proinflammatory molecules. These results suggest that the miR-15a/16-1 cluster is a novel therapeutic target for ischemic stroke.
Source: Stroke - June 26, 2017 Category: Neurology Authors: Xinxin Yang, Xuelian Tang, Ping Sun, Yejie Shi, Kai Liu, Sulaiman H. Hassan, R. Anne Stetler, Jun Chen, Ke-Jie Yin Tags: Basic Science Research, Ischemic Stroke Original Contributions Source Type: research

CCR6 (CC Chemokine Receptor 6) Is Essential for the Migration of Detrimental Natural Interleukin-17-Producing {gamma}{delta} T Cells in Stroke Basic Sciences
Conclusions—Brain-infiltrating IL-17–producing γδ T cells belong to the subset of natural IL-17–producing γδ T cells. In stroke, these previously unrecognized innate lymphocytes trigger a highly conserved immune reaction, which is known from host responses toward pathogens. We demonstrate that therapeutic approaches targeting synergistic IL-17 and tumor necrosis factor-α pathways in parallel offer additional neuroprotection in stroke.
Source: Stroke - June 26, 2017 Category: Neurology Authors: Priyadharshini Arunachalam, Peter Ludewig, Patrick Melich, Thiruma Valavan Arumugam, Christian Gerloff, Immo Prinz, Tim Magnus, Mathias Gelderblom Tags: Animal Models of Human Disease, Basic Science Research, Inflammation, Ischemic Stroke, Neuroprotectants Original Contributions Source Type: research

Recurrent Thromboembolic Events after Ischemic Stroke in Patients with Primary Brain Tumors
Stroke mechanisms and the risk of recurrent thromboembolism are incompletely understood in patients with primary brain tumors. We sought to better delineate these important clinical features.
Source: Journal of Stroke and Cerebrovascular Diseases - June 21, 2017 Category: Neurology Authors: Neal S. Parikh, Jaclyn E. Burch, Hooman Kamel, Lisa M. DeAngelis, Babak B. Navi Source Type: research

Primary Angiitis of the Central Nervous System Clinical Sciences
Conclusions—Adult primary angiitis of the central nervous system is a heterogenous disease, with multiterritorial, distal, and bilateral acute stroke being the most common pattern of parenchymal lesions found on magnetic resonance imaging. Our findings suggest a higher than previously thought prevalence of hemorrhagic transformation and other hemorrhagic manifestations.
Source: Stroke - April 24, 2017 Category: Neurology Authors: Gregoire Boulouis, Hubert de Boysson, Mathieu Zuber, Loic Guillevin, Eric Meary, Vincent Costalat, Christian Pagnoux, Olivier Naggara Tags: Imaging, Magnetic Resonance Imaging (MRI), Cerebrovascular Disease/Stroke, Intracranial Hemorrhage, Ischemic Stroke Original Contributions Source Type: research

Recurrent Stroke after Silent Brain Infarction in Patients with Primary Brain Tumors (S51.007)
Conclusions:The short-term risk of recurrent ischemic stroke in patients with PBTs was substantial and the risk was comparable whether the stroke was silent or symptomatic.Study Supported by: Babak Navi was supported by grants from the NINDS (K23NS091395) and the Florence Gould Endowment for Discovery in Stroke. Hooman Kamel was supported by grants from the NINDS (K23NS082367) and the Michael Goldberg Stroke Research Fund.Disclosure: Dr. Parikh has nothing to disclose. Dr. Burch has nothing to disclose. Dr. Kamel has received personal compensation for activities with Genentech as a speaker. Dr. Kamel has received personal ...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Parikh, N., Burch, J., Kamel, H., DeAngelis, L., Navi, B. Tags: Cerebrovascular Disease and Interventional Neurology: Stroke Prevention and Translation Source Type: research

Recurrent Stroke Due to Metastatic Pulmonary Tumor Emboli as an Important Clinical Entity
We present an autopsy case of repetitive stroke due to tumor emboli, indistinguishable from thromboembolism with a hypercoagulable state in its clinical course. A 72-year-old man diagnosed with stage IVA oropharyngeal squamous cell carcinoma received chemoradiotherapy. Follow-up imaging revealed mediastinal lymph nodes and pulmonary metastasis. One year later, the patient experienced right arm weakness, and brain magnetic resonance imaging showed acute ischemic lesions in multiple vascular territories.
Source: Journal of Stroke and Cerebrovascular Diseases - March 30, 2017 Category: Neurology Authors: Junji Takasugi, Manabu Sakaguchi, Naoki Oyama, Yasufumi Gon, Yasukazu Terasaki, Tsutomu Sasaki, Susumu Nakahara, Kenji Ohshima, Yumiko Hori, Eiichi Morii, Hideki Mochizuki Tags: Case Studies Source Type: research

Human Muse Cells Reconstruct Neuronal Circuitry in Subacute Lacunar Stroke Model Basic Sciences
Conclusions—Transplantation at the delayed subacute phase showed muse cells differentiated into neural cells, facilitated neural reconstruction, improved functions, and displayed solid safety outcomes over prolonged graft maturation period, indicating their therapeutic potential for lacunar stroke.
Source: Stroke - January 22, 2017 Category: Neurology Authors: Hiroki Uchida, Kuniyasu Niizuma, Yoshihiro Kushida, Shohei Wakao, Teiji Tominaga, Cesario V. Borlongan, Mari Dezawa Tags: Cell Therapy, Stem Cells, Translational Studies, Ischemic Stroke Original Contributions Source Type: research

Exendin-4 Inhibits Matrix Metalloproteinase-9 Activation and Reduces Infarct Growth After Focal Cerebral Ischemia in Hyperglycemic Mice Basic Sciences
Conclusions— Treatment with exendin-4 could be a potentially useful therapeutic option for treatment of acute ischemic stroke with transient hyperglycemia.
Source: Stroke - April 24, 2016 Category: Neurology Authors: Kuroki, T., Tanaka, R., Shimada, Y., Yamashiro, K., Ueno, Y., Shimura, H., Urabe, T., Hattori, N. Tags: Treatment, Blood-Brain Barrier, Ischemic Stroke Basic Sciences Source Type: research

Kelsey’s transformation: From stroke survivor to motivational speaker
“When I woke up after my stroke, all I wanted was to be normal again,” recalls Kelsey Tainsh. Normal — as in a healthy teen athlete who could brush her teeth and shower on her own, who wasn’t wheelchair-bound, who wasn’t compelled to hide her paralyzed right hand in her pocket everywhere she went, one who hadn’t lost all of her high school friends except for her two triplet sisters. Now, this world-champion athlete not only learned to walk and talk again but also to embrace her differences. “Our hardest obstacles can be our biggest opportunities,” she says. Kelsey’s first taste of being different came at ...
Source: Thrive, Children's Hospital Boston - March 16, 2016 Category: Pediatrics Authors: Lisa Fratt Tags: Our Patients’ Stories Brain tumor Mark Rockoff R. Michael Scott stroke Source Type: news

Cerebral perfusion in stroke-like migraine attacks after radiation therapy syndrome
We present 2 patients with recurrent attacks of SMART syndrome with increased cerebral blood volume in affected regions and abnormal vascular reactivity on transcranial Doppler ultrasound, suggesting a potential mechanism.
Source: Neurology - February 22, 2016 Category: Neurology Authors: Olsen, A. L., Miller, J. J., Bhattacharyya, S., Voinescu, P. E., Klein, J. P. Tags: MRI, All Clinical Neurology, All Cerebrovascular disease/Stroke, Radiation therapy-tumor CLINICAL/SCIENTIFIC NOTES Source Type: research

D-4F Decreases White Matter Damage After Stroke in Mice Basic Sciences
Conclusions— D-4F treatment initiated 2 h after MCAo decreases neuroinflammation and white matter damage and improves functional outcome after stroke. D-4F-induced increase in IGF1 may contribute to D-4F–induced neurite/axonal outgrowth after stroke.
Source: Stroke - December 28, 2015 Category: Neurology Authors: Cui, X., Chopp, M., Zacharek, A., Cui, C., Yan, T., Ning, R., Chen, J. Tags: Treatment, Ischemic Stroke Basic Sciences Source Type: research

Recurrent stroke in childhood cancer survivors
Conclusion: Survivors of childhood cancer, particularly those previously treated with high-dose cranial radiation, have a high risk of recurrent stroke for decades after a first stroke. Although these strokes are mostly occurring in young adulthood, hypertension, an established atherosclerotic risk factor, independently predicts recurrent stroke in this population.
Source: Neurology - September 21, 2015 Category: Neurology Authors: Fullerton, H. J., Stratton, K., Mueller, S., Leisenring, W. W., Armstrong, G. T., Weathers, R. E., Stovall, M., Sklar, C. A., Goldsby, R. E., Robison, L. L., Krull, K. R. Tags: Childhood stroke, Stroke in young adults, All Cerebrovascular disease/Stroke, Primary brain tumor ARTICLE Source Type: research

Intravenous Bone Marrow Stem Cell Grafts Preferentially Migrate to Spleen and Abrogate Chronic Inflammation in Stroke Basic Sciences
Conclusions— hBMSC transplantation is therapeutic in chronic stroke possibly by abrogating the inflammation-plagued secondary cell death.
Source: Stroke - August 24, 2015 Category: Neurology Authors: Acosta, S. A., Tajiri, N., Hoover, J., Kaneko, Y., Borlongan, C. V. Tags: Animal models of human disease, Pathology of Stroke, Other Stroke Treatment - Surgical Basic Sciences Source Type: research

Therapeutically Targeting Tumor Necrosis Factor-{alpha}/Sphingosine-1-Phosphate Signaling Corrects Myogenic Reactivity in Subarachnoid Hemorrhage Basic Sciences
Conclusions— Vascular smooth muscle cell TNFα and sphingosine-1-phosphate signaling significantly enhance cerebral artery tone in SAH; anti-TNFα and anti–sphingosine-1-phosphate treatment may significantly improve clinical outcome.
Source: Stroke - July 27, 2015 Category: Neurology Authors: Yagi, K., Lidington, D., Wan, H., Fares, J. C., Meissner, A., Sumiyoshi, M., Ai, J., Foltz, W. D., Nedospasov, S. A., Offermanns, S., Nagahiro, S., Macdonald, R. L., Bolz, S.-S. Tags: Animal models of human disease, Acute Cerebral Hemorrhage, Brain Circulation and Metabolism, Other Stroke Treatment - Medical, Other Vascular biology Basic Sciences Source Type: research

Chronic Elevation of Tumor Necrosis Factor-{alpha} Mediates the Impairment of Leptomeningeal Arteriogenesis in db/db Mice Basic Sciences
Conclusions— These results indicate that leptomeningeal arteriogenesis is impaired in db/db mice and that suppression of the tumor necrosis factor-α response to hypoperfusion is the major contributing factor.
Source: Stroke - May 22, 2015 Category: Neurology Authors: Yukami, T., Yagita, Y., Sugiyama, Y., Oyama, N., Watanabe, A., Sasaki, T., Sakaguchi, M., Mochizuki, H., Kitagawa, K. Tags: Cerebrovascular disease/stroke, Type 2 diabetes, Other Vascular biology Basic Sciences Source Type: research

Misdiagnosis in Young Patients with Ischemic Stroke (P7.122)
Conclusions It is essential to increase awareness that young patients with stroke may present to emergency department with minor symptoms of artery dissection mainly involving the posterior circulation and lacking cardiovascular risk factors.Disclosure: Dr. Leon has nothing to disclose. Dr. Pantiu has nothing to disclose. Dr. Quiroga has nothing to disclose. Dr. Bonardo has nothing to disclose. Dr. Uribe has nothing to disclose. Dr. Mazziotti has received research support from Shire Pharmaceuticals Group. Dr. Zinnerman has nothing to disclose. Dr. Martinez has nothing to disclose. Dr. Sotelo has nothing to disclose. Dr. Ju...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Leon, L., Pantiu, F., Quiroga, J., Bonardo, P., Uribe, C., Mazziotti, J., Zinnerman, A., Martinez, A., Sotelo, A., Jure, L., Nofal, P., Bendersky, E., Sposato, L. A., Riccio, P., Reisin, R., Fernandez Pardal, M. Tags: Cerebrovascular Disease and Interventional Neurology: Stroke in Young Source Type: research

Intervention of Death-Associated Protein Kinase 1-p53 Interaction Exerts the Therapeutic Effects Against Stroke Brief Reports
Conclusions— DAPK1–p53 interaction is a preferred target for therapeutic intervention of stroke.
Source: Stroke - September 22, 2014 Category: Neurology Authors: Wang, X., Pei, L., Yan, H., Wang, Z., Wei, N., Wang, S., Yang, X., Tian, Q., Lu, Y. Tags: Neuroprotectors Brief Reports Source Type: research

Effective Mechanical Thrombectomy in a Patient with Hyperacute Ischemic Stroke Associated with Cardiac Myxoma
We describe a patient with hyperacute stroke caused by cardiac myxoma who had a good outcome with rapid recanalization through mechanical thrombectomy. A 46-year-old man was admitted with acute symptoms of right side hemiplegia and global aphasia. Brain computed tomography (CT) angiography showed a T occlusion of the left internal carotid artery. Intravenous recombinant tissue plasminogen activator was administered. However, his clinical symptoms did not improve. Thus, we performed endovascular treatment and had a successful outcome. A pathologic examination of the retrieved clot revealed a tumor emboli from a cardiac myxo...
Source: Journal of Stroke and Cerebrovascular Diseases - September 1, 2014 Category: Neurology Authors: Seol-Hee Baek, Soonchan Park, Nam Joon Lee, Youngjin Kang, Kyung-Hee Cho Tags: Case Reports Source Type: research

Fatal Intracranial Hemorrhage after Intravenous Thrombolytic Therapy for Acute Ischemic Stroke Associated with Cancer-related Nonbacterial Thrombotic Endocarditis
Nonbacterial thrombotic endocarditis (NBTE) is associated with hypercoagulability in patients with inflammatory states such as cancer and autoimmune diseases. Cardiac vegetations caused by NBTE often lead to life-threatening systemic thromboembolism that most frequently affects the brain, spleen, and kidneys. A 54-year-old woman diagnosed with ovarian cancer suddenly developed back pain and left hemiparesis. Although intravenous alteplase (rt-PA) therapy was administered to treat hyperacute ischemic infarction detected by magnetic resonance imaging, intracranial hemorrhage occurred in the left hemisphere several hours late...
Source: Journal of Stroke and Cerebrovascular Diseases - August 11, 2014 Category: Neurology Authors: Takuya Yagi, Kie Takahashi, Mariko Tanikawa, Morinobu Seki, Takato Abe, Norihiro Suzuki Tags: Case Reports Source Type: research

Emergency physicians distinguish between Bell's palsy and stroke
Emergency physicians correctly identified nearly 100 percent of patients with Bell's palsy, the symptoms of which are nearly identical to potentially life-threatening diseases such as stroke and brain tumors. The results of a study of 6 years of California patient records were published online yesterday in Annals of Emergency Medicine ("Potential Misdiagnoses of Bell's Palsy in the Emergency Department")...
Source: Health News from Medical News Today - July 29, 2013 Category: Consumer Health News Tags: Stroke Source Type: news