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Perlecan, a Modular Instructive Proteoglycan with Diverse Functional Properties.
This study reviewed some new aspects of the modular proteoglycan perlecan, a colossal proteoglycan with a 467 kDa core protein and five distinct functional domains. Perlecan is a heparan sulphate proteoglycan that transiently displays native CS sulphation motifs 4-C-3 and 7-D-4 during tissue morphogenesis these are expressed by progenitor cell populations during tissue development. Perlecan is susceptible to fragmentation by proteases during tissue development and in pathological tissues particularly in domains IV and V. The fragmentation pattern of domain IV has been suggested as a means of grading prostate cancer. Doma...
Source: The International Journal of Biochemistry and Cell Biology - September 14, 2020 Category: Biochemistry Authors: Melrose J Tags: Int J Biochem Cell Biol Source Type: research
Coronary Artery Bypass Grafting in Cancer Patients: Prevalence and Outcomes in the United States.
CONCLUSION: Among those undergoing CABG, the prevalence of comorbid cancer has steadily increased. Outside of major bleeding, these patients appear to share similar outcomes to those without cancer indicating that CABG utilization should be not be declined in cancer patients when otherwise indicated. Further research into the factors underlying the decision to pursue CABG in specific cancer sub-groups is needed. PMID: 32861331 [PubMed - in process]
Source: Clinical Prostate Cancer - August 31, 2020 Category: Cancer & Oncology Authors: Guha A, Dey AK, Kalra A, Gumina R, Lustberg M, Lavie CJ, Sabik JF, Addison D Tags: Mayo Clin Proc Source Type: research
SNMMI 2020: AI analysis of PET could help classify prostate cancer
An artificial intelligence (AI) algorithm may be able to assist in classifying...Read more on AuntMinnie.comRelated Reading: SNMMI 2020: PET/MRI combo tracks osteoarthritis progression SNMMI 2020: PSMA-PET/CT changes prostate cancer management SNMMI 2020: PET tracer could image, treat glioblastoma SNMMI 2020: PET radiotracer measures stroke recovery SNMMI 2020: AI can aid in diagnosis of Parkinson's disease
Source: AuntMinnie.com Headlines - July 17, 2020 Category: Radiology Source Type: news
Gonadotropin-releasing hormone agonists, anti-androgens and the risk of cardio-cerebrovascular disease in prostate cancer patients: an asian population-based observational study
Conclusions: The current study based on Asian population suggests that treatment with neither GnRH agonist nor antiandrogens increases the risk of cardio-cerebrovascular disease compared to patients with ADT-naïve prostate cancer.
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Jong-Mi Seong, Dongho Shin, Jae Woo Sung, Shinjay Cho, Jonghyup Yang, Sungmin Kang, Hyong Woo Moon, Kyu Won Lee, U-Syn Ha Tags: Research Paper Source Type: research
Prostate Cancer Drug Could Be 'Game Changing'
For men with advanced prostate cancer, a new hormone therapy pill works better than standard injections -- and carries a much lower risk of heart attack or stroke.
Source: WebMD Health - May 29, 2020 Category: Consumer Health News Source Type: news
Prostate Cancer Drug Could Be ' Game Changing, ' Researchers Say
FRIDAY, May 29, 2020 -- For men with advanced prostate cancer, a new hormone therapy pill works better than standard injections -- and carries a much lower risk of heart attack or stroke, a clinical trial has found. The drug, called relugolix, is...
Source: Drugs.com - Daily MedNews - May 29, 2020 Category: General Medicine Source Type: news
Co-morbidities in a Retrospective Cohort of Prostate Cancer Patients.
Conclusion: Better chronic disease management is needed among prostate cancer survivors through more effective survivorship care planning and interventions that promote health behaviors. PMID: 32269460 [PubMed - in process]
Source: Ethnicity and Disease - April 11, 2020 Category: International Medicine & Public Health Tags: Ethn Dis Source Type: research
In memoriam: Haines Ely, MD, FAAD
Aside from the news about the canceling of the American Academy of Dermatology Annual Meeting in Denver, there is horrible news that is difficult with every key stroke as I write today …Dr Haines Ely, long-standing pinnacle member of Noah Worcester, Pacific Dermatologic Association, RxDerm, and the American Academy of Dermatology, has passed away after a long battle with prostate cancer. He is survived by his wife, Jenny, and adult daughters, Meredith Bordoni (Michael), Rebecca Ely, and Tess Ely.
Source: Journal of the American Academy of Dermatology - March 12, 2020 Category: Dermatology Authors: Neal Bhatia Tags: In memoriam Source Type: research
Omega-3 fats do not protect against cancer
(University of East Anglia) Omega-3 fats do not protect against cancer -- according to new University of East Anglia research. Increased consumption of omega-3 fats is widely promoted globally because of a common belief that it will protect against, or even reverse, diseases such as cancer, heart attacks and stroke. But two systematic reviews find that omega-3 supplements may slightly reduce coronary heart disease mortality and events, but slightly increase risk of prostate cancer. Both beneficial and harmful effects are small.
Source: EurekAlert! - Cancer - February 28, 2020 Category: Cancer & Oncology Source Type: news
“One stroke, with twenty-two people”: exploring prostate cancer survivors' participation in dragon boating
Source: Journal of Psychosocial Oncology - February 16, 2020 Category: Cancer & Oncology Authors: Isabella V. Cin à Katie M. Di Sebastiano Guy E. Faulkner Source Type: research
To the Horizon: The Brink of an AI Revolution in Prostate Cancer?
Noorbakhsh-Sabet et al.1 published an excellent review in The American Journal of Medicine summarizing the potential of artificial intelligence (AI) in medicine. They describe wide utility (e.g. in dermatology and stroke), but do not consider surgery and urology, which embrace cutting-edge technology, including fusion-biopsy and robotics,2 and will be early AI adopters. Indeed, prostate cancer creates a huge health care burden, thus being ideal for AI transformation.
Source: The American Journal of Medicine - January 16, 2020 Category: General Medicine Authors: Joseph M. Norris, Asif Raza Tags: Letter Source Type: research
Cancers, Vol. 12, Pages 189: Influence of Baseline Cardiovascular Comorbidities on Mortality after Androgen Deprivation Therapy for Metastatic Prostate Cancer
ih Shao Few studies have assessed the benefits of androgen deprivation therapy (ADT) in men with metastatic prostate cancer (PC; mPC) at an old age or with major cardiovascular conditions. A retrospective cohort consisted of 3835 men with newly diagnosed mPC from the Taiwan Cancer Registry of 2008&ndash;2014. Among them, 2692 patients received only ADT in the first year after the cancer diagnosis, and 1143 patients were on watchful waiting. The inverse probability of treatment-weighted Cox model was used to estimate the effects of ADT on all-cause mortality and PC-specific mortality according to age, and the...
Source: Cancers - January 11, 2020 Category: Cancer & Oncology Authors: Wu Fang Hwang Shih Shao Tags: Article Source Type: research
U.S. Cancer Death Rates Continue to Drop, But Progress Is Stalling for Some Cancers
Over the last few decades, the death rate from cancer dropped by 29% in the U.S., according to the latest data from the American Cancer Society (ACS). That, the ACS’s new study estimates, saved 2.9 million lives from 1991 to 2017, largely owing to declines in mortality from the four leading cancer types: lung, breast, prostate and colon. From 2016 to 2017—the latest year for which data are available—the overall cancer death rate declined by 2.2%, the largest single-year reduction ever recorded. These new figures were reported in a study published in CA: A Cancer Journal for Clinicians. The declines are a...
Source: TIME: Health - January 8, 2020 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized Cancer Source Type: news
Risk of ischemic stroke in patients with prostate cancer receiving androgen deprivation therapy in Taiwan
Androgen deprivation therapy (ADT) in the treatment of prostate cancer may be associated with an increased risk of thromboembolic disease. The aim of our study was to investigate the association of ADT in the ...
Source: BMC Cancer - December 30, 2019 Category: Cancer & Oncology Authors: Kuang-Ming Liao, Yaw-Bin Huang, Chung-Yu Chen and Chen-Chun Kuo Tags: Research article Source Type: research
Pharmacological treatment of NASH.
Abstract Lifestyle modifications, especially weight loss, are efficient on NASH liver injury, however rarely followed in clinical practice. The target population of pharmacologic treatments is represented by patients with NASH and fibrosis. Out of histological improvement, efficacy of treatments should be assessed through liver morbi-mortality benefit, but also on extrahepatic events, such as cardiovascular. Among anti-diabetic treatments, glitazones et GLP-1 agonists have shown efficacy on histological liver injury. Vitamin E is efficient on liver injury but at the cost of prostate cancer and stroke over risk. Ab...
Source: Presse Medicale - November 18, 2019 Category: General Medicine Authors: Serfaty L Tags: Presse Med Source Type: research
N-acetylaspartylglutamate (NAAG) and Glutamate Carboxypeptidase II: An abundant peptide neurotransmitter-enzyme system with multiple clinical applications
Publication date: Available online 12 November 2019Source: Progress in NeurobiologyAuthor(s): Joseph H. Neale, Tatsuo YamamotoAbstractN-Acetylaspartylglutamate (NAAG) is the third most prevalent neurotransmitter in the mammalian nervous system, yet its therapeutic potential is only now being fully recognized. Drugs that inhibit the inactivation of NAAG by glutamate carboxypeptidase II (GCPII) increase its extracellular concentration and its activation of its receptor, mGluR3. These drugs warrant attention, as they are effective in animal models of several clinical disorders including stroke, traumatic brain injury and schi...
Source: Progress in Neurobiology - November 13, 2019 Category: Neuroscience Source Type: research
Medium and long-term risks of specific cardiovascular diseases in survivors of 20 adult cancers: a population-based cohort study using multiple linked UK electronic health records databases
In this study, we used large-scale electronic health records data from multiple linked UK databases to address these evidence gaps.MethodsFor this population-based cohort study, we used linked primary care, hospital, and cancer registry data from the UK Clinical Practice Research Datalink to identify cohorts of survivors of the 20 most common cancers who were 18 years or older and alive 12 months after diagnosis and controls without history of cancer, matched for age, sex, and general practice. We compared risks for a range of cardiovascular disease outcomes using crude and adjusted Cox models. We fitted interactions to in...
Source: The Lancet - August 21, 2019 Category: General Medicine Source Type: research
Variation of all-cause and cause-specific mortality with body mass index in one million Swedish parent-son pairs: An instrumental variable analysis
ConclusionsConsistent with previous large-scale meta-analyses and reviews, results supported the causal role of higher BMI in increasing the risk of several common causes of death, including cancers with increasing global incidence. We also found positive effects of BMI on mortality from respiratory disease, prostate cancer, and lung cancer, which has been inconsistently reported in the literature, suggesting that the causal role of higher BMI in mortality from these diseases may be underestimated. Furthermore, we expect different patterns of bias in the current observational and IV analyses; therefore, the similarities be...
Source: PLoS Medicine - August 8, 2019 Category: Internal Medicine Authors: Kaitlin H. Wade Source Type: research
Specific Biomarkers of Prostate Cancer-Associated Ischemic Stroke: A Case-Control Study.
CONCLUSIONS</strong> Elevated levels of D-dimer and T-PSA and increased NLR are independent risk factors of PCaIS. The multiple model of PCaIS can be a specific biomarker and is a reliable predictor of development of PCaIS. PMID: 31383837 [PubMed - in process]
Source: Medical Science Monitor - August 7, 2019 Category: Research Tags: Med Sci Monit Source Type: research
Cancer Survivorship and Subclinical Myocardial Damage.
Abstract The rate of cardiovascular disease among cancer survivors is higher than in the general population. This difference is due to traditional CVD risk factors and also to the cardiotoxicity of cancer treatment. In a population-based cohort study of 3,512 men and women who were free of CVD at visit 5, Florido et al. evaluated the association of cancer survivorship with subclinical myocardial damage, as assessed by elevated high-sensitivity cardiac Troponin T (hs-cTnT). Cancer survivors had significantly higher odds of elevated hs-cTnT (odds ratio [OR] = 1.26, 95% confidence interval [CI] 1.03, 1.53). Results w...
Source: Am J Epidemiol - July 7, 2019 Category: Epidemiology Authors: Coughlin SS, Kapuku G Tags: Am J Epidemiol Source Type: research
Dairy foods and health: an umbrella review of observational studies.
In conclusions, dairy may be part of a healthy diet; however, additional studies exploring confounding factors are needed to ascertain the potential detrimental effects. PMID: 31199182 [PubMed - as supplied by publisher]
Source: International Journal of Food Sciences and Nutrition - June 16, 2019 Category: Nutrition Tags: Int J Food Sci Nutr Source Type: research
Is androgen deprivation therapy associated with cerebral infarction in patients with prostate cancer? A Korean nationwide population ‐based propensity score matching study
ConclusionThis nationwide population ‐based study revealed that ADT was not associated with cerebral infarction after adjusting for potential confounders.
Source: Cancer Medicine - June 9, 2019 Category: Cancer & Oncology Authors: Bum Sik Tae, Byeong Jo Jeon, Hoon Choi, Jae Hyun Bae, Jae Young Park Tags: ORIGINAL RESEARCH Source Type: research
Sex Difference of Radiation Response in Occupational and Accidental Exposure
Conclusion and Outlook This review summarizes the data from major human studies on the health risks of radiation exposure and shows that sex can potentially influence the prolonged response to radiation exposure (Figure 1 and Tables 1, 2). These data suggest that long-term radiosensitivity in females is higher than that in males who receive a comparable dose of radiation. Our analysis of the literature agrees with the conclusions of the recent report on the Biological effects of ionizing radiation (BEIR VII) published in 2006 by the National Academy of Sciences (NAS), United States (National Research Council, 2006). The B...
Source: Frontiers in Genetics - May 2, 2019 Category: Genetics & Stem Cells Source Type: research
Sex Differences in Sex Hormone Profiles and Prediction of Consciousness Recovery After Severe Traumatic Brain Injury
Conclusion: These findings indicate that TBI differentially affects the levels of sex-steroid hormones in men and women patients. Plasma levels of testosterone could be a good candidate blood marker to predict recovery from unconsciousness after sTBI for male patients. Introduction Traumatic brain injury (TBI) is a major cause of death and disability worldwide and is increasing in incidence (1). Patients with acute severe TBI (sTBI) often develop severe disorders of consciousness, i.e., coma, minimally conscious state or vegetative state. Although many patients may regain consciousness during the 1-month post-TBI p...
Source: Frontiers in Endocrinology - April 25, 2019 Category: Endocrinology Source Type: research
A Genetic Variant of miR-34a Contributes to Susceptibility of Ischemic Stroke Among Chinese Population
This study was supported by National Natural Science Foundation of China (Nos. 81560552, 81260234), Natural Science Foundation of Guangxi Zhuang Autonomous Region (CN) (2017JJA180826), Innovation Project of Guangxi Graduate Education (CN) (201601009) and Key Laboratory Open Project Fund of Guangxi Zhuang Autonomous Region (CN) (kfkt20160064). Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Supplementary Material The Supplementary Material for this article can be fou...
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research
Exercise as a Prescription for Patients with Various Diseases
Publication date: Available online 18 April 2019Source: Journal of Sport and Health ScienceAuthor(s): Xin Luan, Xiangyang Tian, Haixin Zhang, Rui Huang, Na Li, Peijie Chen, Ru WangAbstractA growing understanding of the benefits of exercise over the past few decades has prompted researchers to take an interest in the possibilities of exercise therapy. Because each sport has its own set of characteristics and physiological complications that tend to appear during exercise training, the effects and underlying mechanisms of exercise remain unclear. Thus, the first step in probing exercise effects on different diseases is the s...
Source: Journal of Sport and Health Science - April 20, 2019 Category: Sports Medicine Source Type: research
Canagliflozin Inhibits Human Endothelial Cell Proliferation and Tube Formation
In conclusion, the present study identified canagliflozin as a potent inhibitor of human EC proliferation. The anti-proliferative action of canagliflozin is observed in ECs isolated from both the venous and arterial circulation, and is partly due to the blockade of cyclin A expression. In addition, this study found that canagliflozin inhibits tube formation in cultured ECs and mouse aortic rings. Notably, these actions are specific for canagliflozin and not seen with other SGLT2 inhibitors. The ability of canagliflozin to exert these pleiotropic effects on EC function may contribute to both the adverse and salutary actions...
Source: Frontiers in Pharmacology - April 15, 2019 Category: Drugs & Pharmacology Source Type: research
Stroke and thromboembolic events in men with prostate cancer treated with definitive radiation therapy with or without androgen deprivation therapy
Stroke and thromboembolic events in men with prostate cancer treated with definitive radiation therapy with or without androgen deprivation therapy, Published online: 15 April 2019; doi:10.1038/s41391-019-0150-5Stroke and thromboembolic events in men with prostate cancer treated with definitive radiation therapy with or without androgen deprivation therapy
Source: Prostate Cancer and Prostatic Diseases - April 14, 2019 Category: Urology & Nephrology Authors: Rishi Deka Daniel R. Simpson Matthew S. Panizzon Richard L. Hauger Paul Riviere Vinit Nalawade Rana McKay James D. Murphy Brent S. Rose Source Type: research
Connecting Metainflammation and Neuroinflammation Through the PTN-MK-RPTP β/ζ Axis: Relevance in Therapeutic Development
Conclusion The expression of the components of the PTN-MK-RPTPβ/ζ axis in immune cells and in inflammatory diseases suggests important roles for this axis in inflammation. Pleiotrophin has been recently identified as a limiting factor of metainflammation, a chronic pathological state that contributes to neuroinflammation and neurodegeneration. Pleiotrophin also seems to potentiate acute neuroinflammation independently of the inflammatory stimulus while MK seems to play different -even opposite- roles in acute neuroinflammation depending on the stimulus. Which are the functions of MK and PTN in chronic neuroi...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research
6-Bromoindirubin-3 ′-Oxime (6BIO) Suppresses the mTOR Pathway, Promotes Autophagy, and Exerts Anti-aging Effects in Rodent Liver
In this study, we aimed to investigate the anti-aging effect, and molecular mechanism, of the novel anti-aging drug 6BIO on naturally aged mouse liver. Rapamycin, a well-known promising anti-aging drug that delays aging through mTOR-dependent autophagy (Zhou and Ye, 2018), was used as the positive control in the study. To our knowledge, this is the first study to demonstrate the effects of 6BIO treatment in models of natural aging. Our results indicated that 6BIO ameliorates the decline of liver function with age, including lipid metabolism disorder, and attenuates hepatocyte senescence in aged mice, as revealed by altera...
Source: Frontiers in Pharmacology - April 9, 2019 Category: Drugs & Pharmacology Source Type: research
2019 Alzheimer's disease facts and figures
This article describes the public health impact of Alzheimer's disease (AD), including incidence and prevalence, mortality and morbidity, use and costs of care, and the overall impact on caregivers and society. The Special Report examines the use of brief cognitive assessments by primary care physicians as a tool for improving early detection of dementia. An estimated 5.8 million Americans have Alzheimer's dementia. By mid-century, the number of people living with Alzheimer's dementia in the United States may grow to 13.8 million, fueled in large part by the aging baby boom generation. In 2017, official death certificates ...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - March 7, 2019 Category: Geriatrics Source Type: research
The association between education and risk of major cardiovascular events among prostate cancer patients: a study from the Diet, Cancer and Health study.
CONCLUSIONS: The risk of acute myocardial infarction was increased in prostate cancer patients with short or medium education compared with long education. Although the educational inequality did not seem to be explained by differences in treatment, lifestyle or cardiovascular risk factors, monitoring of cardiovascular health and health promotion should involve all prostate cancer patients regardless of social position to ensure best prognosis for all. PMID: 30757932 [PubMed - as supplied by publisher]
Source: Acta Oncologica - February 13, 2019 Category: Cancer & Oncology Authors: Moustsen IR, Friberg AS, Larsen SB, Duun-Henriksen AK, Tjønneland A, Kjaer SK, Brasso K, Johansen C, Dalton SO Tags: Acta Oncol Source Type: research
A prospective study of health conditions related to alcohol consumption cessation among 97,852 drinkers aged 45 and over in Australia.
CONCLUSIONS: Diagnosis with a variety of health conditions appears to prompt drinking cessation in older adults. This article is protected by copyright. All rights reserved. PMID: 30758044 [PubMed - as supplied by publisher]
Source: Alcoholism, Clinical and Experimental Research - February 13, 2019 Category: Addiction Authors: Sarich P, Canfell K, Banks E, Paige E, Egger S, Joshy G, Korda R, Weber M Tags: Alcohol Clin Exp Res Source Type: research
How Might Bromodomain and Extra-Terminal (BET) Inhibitors Operate in Cardiovascular Disease?
AbstractBromodomain and extra-terminal (BET) inhibitors, acting via epigenetic mechanisms, have been developed recently as potential new treatments for cancer, including prostate cancer, and inflammatory conditions. Some BET inhibitors, such as RVX-208, also raise high-density lipoprotein cholesterol (HDL-C) and apolipoprotein A-1 levels. A recent meta-analysis of three small trials (n = 798) found that RVX-208 protected against major adverse cardiovascular events (MACE), raising the question as to whether this protective effect was an artefact, a chance finding, or mediated by HDL-C, anti-inflammatory pathways, or oth...
Source: American Journal of Cardiovascular Drugs - January 29, 2019 Category: Cardiology Source Type: research
Korean JLK Inspection launches AI-powered imaging diag system
Korean JLK Inspection said yesterday that it launched its AIHub artificial intelligence-powered medical image diagnostics platform. The newly launched AIHub system is designed to analyze images from a number of different imaging modalities, including magnetic resonance imaging, computed tomography, X-ray and mammography, the Seoul-based company said. JLK Inspection claims the system can detect and monitor for more than 30 medical conditions in 14 regions of the body. The company added that the system is focused on brain diseases and conditions including ischemic stroke, hemorrhagic stroke, brain aneurysm and Alzheimer̵...
Source: Mass Device - December 27, 2018 Category: Medical Devices Authors: Fink Densford Tags: Diagnostics Imaging Software / IT jlkinspection Source Type: news
Monoclonal Gammopathy of Undetermined Significance - Patient Characteristics and Referral Patterns
ConclusionMGUS is often incidentally detected as part of a work up for other medical conditions, and our results reveal that there is a variety of reasons for which monoclonal testing is performed. With recent developments in our understanding of the significance of monoclonal gammopathy and its association with certain renal and organ damage (Fermand et al., 2018; Leung et al., 2012), there may be a change in how the paraproteinemia investigations are utilized by clinicians in different disciplines. It will be important to recognize and establish appropriate indications for testing. Furthermore, MGUS patients present with...
Source: Blood - November 21, 2018 Category: Hematology Authors: Lee, H., Street, L., Tay, J., Grossman, J., Thaell, J. F., Goodyear, D., McCulloch, S., Duggan, P., Neri, P., Jimenez-Zepeda, V. Tags: 651. Myeloma: Biology and Pathophysiology, excluding Therapy: Poster III Source Type: research
Prostate Artery Embolization in Patients with Prostate Volumes of 80 mL or More: A Single-Institution Retrospective Experience of 93 Patients
ConclusionsPAE achieved a clinically and statistically significant improvement in symptom burden and secondary outcome measures in patients with PVs ≥ 80 mL. PAE may be an alternate treatment for patients for whom conventional surgical options are limited or associated with significant morbidity.
Source: Journal of Vascular and Interventional Radiology - September 12, 2018 Category: Radiology Source Type: research
Public health implications of overscreening for carotid artery stenosis, prediabetes, and thyroid cancer.
Conclusions: Screening for carotid artery stenosis, prediabetes, and thyroid cancer in an asymptomatic population can result in unnecessary, harmful, and costly care. Systemic challenges to lowering overscreening include lack of clinician awareness, examination of conflicts of interests, perverse financial incentives, and communication with the general public. PMID: 29988604 [PubMed]
Source: Public Health Reviews - July 11, 2018 Category: International Medicine & Public Health Tags: Public Health Rev Source Type: research
Metastatic prostate cancer mimicking a subdural hematoma: A case report and literature review
Publication date: Available online 4 July 2018Source: Journal of Clinical NeuroscienceAuthor(s): Andrew Nunno, Mahlon D. Johnson, Guan Wu, Yan Michael LiAbstractOccurrences of metastatic prostate cancer imitating a subdural hematoma are limited to a small number of case reports, even though prostate cancer spreads to the dura more than other types of cancer. Here, we present the case of a 64 year-old male whose prostate carcinoma’s metastasis mimicked a subdural hematoma, and he suffered a middle cerebral artery stroke. Prostate cancer’s high rate of progression to the dura is disproportionate to its relatively low r...
Source: Journal of Clinical Neuroscience - July 10, 2018 Category: Neuroscience Source Type: research
Metastatic prostate cancer mimicking a subdural hematoma: A case report and literature review.
Abstract Occurrences of metastatic prostate cancer imitating a subdural hematoma are limited to a small number of case reports, even though prostate cancer spreads to the dura more than other types of cancer. Here, we present the case of a 64 year-old male whose prostate carcinoma's metastasis mimicked a subdural hematoma, and he suffered a middle cerebral artery stroke. Prostate cancer's high rate of progression to the dura is disproportionate to its relatively low rate of brain metastasis. Furthermore, we explore the potential molecular implications of prostate cancer's propensity to spread to the dura. P...
Source: Clinical Prostate Cancer - July 4, 2018 Category: Cancer & Oncology Authors: Nunno A, Johnson MD, Wu G, Li YM Tags: J Clin Neurosci Source Type: research
Metastatic prostate cancer mimicking a subdural hematoma: A case report and literature review
Publication date: Available online 4 July 2018 Source:Journal of Clinical Neuroscience Author(s): Andrew Nunno, Mahlon D. Johnson, Guan Wu, Yan Michael Li Occurrences of metastatic prostate cancer imitating a subdural hematoma are limited to a small number of case reports, even though prostate cancer spreads to the dura more than other types of cancer. Here, we present the case of a 64 year-old male whose prostate carcinoma’s metastasis mimicked a subdural hematoma, and he suffered a middle cerebral artery stroke. Prostate cancer’s high rate of progression to the dura is disproportionate to its relatively low rate o...
Source: Journal of Clinical Neuroscience - July 4, 2018 Category: Neuroscience Source Type: research
Abstract 14: The Influence of Provider Specialty on Anticoagulation Prescription Fills and Stroke Risk in Atrial Fibrillation Patients With History of Cancer Session Title: Poster Session Reception: Young Investigator Award Semi-Finalists
Conclusion: AF patients with cancer were less likely to see a cardiologist, and less likely to fill an anticoagulant prescription than AF patients without cancer. However, cardiology involvement was associated with increased anticoagulant prescription fills and reduced risk of stroke, suggesting a beneficial role for cardiology providers to improve outcomes in AF patients with history of cancer.
Source: Circulation: Cardiovascular Quality and Outcomes - April 5, 2018 Category: Cardiology Authors: ONeal, W. T., Claxton, J., MacLehose, R., Chen, L., Bengtson, L. G., Chamberlain, A. M., Norby, F., Lutsey, P., Alonso, A. Tags: Session Title: Poster Session Reception: Young Investigator Award Semi-Finalists Source Type: research
Stroke rates appear to be rising steadily in young adults
The rate of stroke among young people has apparently been rising steadily since 1995, according to a study published this week. Hospitalization rates for stroke increased for women between the ages of 18 and 44, and nearly doubled for men in that age range from 1995 through 2012. Using more-detailed data for 2003 through 2012, the researchers found that rates […]Related:California vaccination rate hits new high after tougher immunization lawRisk of a rare but deadly mouse-borne virus increases in the springThe federal panel that opposed prostate cancer screening just changed its mind
Source: Washington Post: To Your Health - April 15, 2017 Category: Consumer Health News Source Type: news
18F-Choline Uptake in Acute Ischemic Stroke
Abstract: A 75-year-old man with a history of prostate cancer was referred to our department to perform 18F-choline (FCH) PET/CT. FCH PET/CT showed a markedly increased uptake in the right temporoparietal junction brain. Three weeks earlier, acute ischemic stroke was diagnosed in the right temporoparietal junction brain on diffusion-weighted sequence and thrombosis in a distal branch of the right middle cerebral artery on MR angiography. Choline precursors promote repair and growth of cell membranes in neurologic diseases, so FCH PET/CT uptake could be explained by repair processes during early outcome of acute ischemic stroke.
Source: Clinical Nuclear Medicine - January 10, 2017 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
Subacute Stroke Mimicking Cerebral Metastasis in 68Ga-PSMA-HBED-CC PET/CT
Abstract: A 65-year-old man with disseminated bone metastases of prostate cancer was referred for 68Ga-PSMA-HBED-CC-PET/CT (short PSMA-PET/CT) to exclude visceral metastases before treatment of bone metastases with 223Ra-dichloride. Apart from disseminated bone metastases, PSMA-PET/CT revealed a focal cerebral tracer uptake in the right frontal lobe highly suspicious for cerebral spread. According to patient history, a cerebral infarction occurred 14 days before PSMA imaging in corresponding localization confirmed by MRI scanning. This case demonstrates the possibility of false-positive finding of cerebral metastases in PS...
Source: Clinical Nuclear Medicine - September 8, 2016 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
CHADS2 scores as a predictor of ischemic stroke after radical prostatectomy
This study assesses the predictive value of CHADS2 scores and CCIS for stroke among patients with prostate cancer. The study was conducted based on data taken from Taiwan's National Health Insurance Research Database (NHIRD). We identified a total of 5414 participants with nonatrial fibrillation (AF) prostate cancer diagnoses who underwent radical prostatectomy between 1997 and 2011. CHADS2 scores and CCIS were used to stratify the 5‐year ischemic stroke risk. All participants were followed from the date of enrollment until ischemic stroke, death, or the end of the 5‐year follow‐up period. The 5‐year risk of ischem...
Source: Cancer Medicine - November 21, 2015 Category: Cancer & Oncology Authors: Yu‐Wan Yang, Shang‐Sen Lee, Chi‐Cheng Chen, Hsin‐Ho Liu, Tsung‐Hsun Tsai, Tien‐Huang Lin, Teng‐Fu Hsieh Tags: Original Research Source Type: research
Risk of ischemic stroke after androgen deprivation therapy for prostate cancer in the Chinese population living in Hong Kong
Conclusions There was increased risk of ischemic stroke after androgen deprivation therapy for prostate cancer in the Chinese population. The risk of ischemic stroke should be considered while deciding on androgen deprivation therapy, especially in older patients with known history of hyperlipidemia.
Source: Japanese Journal of Clinical Oncology - April 28, 2015 Category: Cancer & Oncology Authors: Teoh, J. Y. C., Chiu, P. K. F., Chan, S. Y. S., Poon, D. M. C., Cheung, H. Y., Hou, S. S. M., Ng, C.-F. Tags: Urology, Original Articles Source Type: research
Association between Incident Cancer and Subsequent Stroke
This article is protected by copyright. All rights reserved.
Source: Annals of Neurology - December 1, 2014 Category: Neurology Authors: Babak B. Navi, Anne S. Reiner, Hooman Kamel, Costantino Iadecola, Mitchell S.V. Elkind, Katherine S. Panageas, Lisa M. DeAngelis Tags: Research Article Source Type: research
Prior Cancer in Patients with Ischemic Stroke: The Bergen NORSTROKE Study
Conclusions: The prevalence of prior cancer is higher in ISP than in the general population. ISPs with prior cancer are more prone to cardioembolism.
Source: Journal of Stroke and Cerebrovascular Diseases - September 27, 2013 Category: Neurology Authors: Henriette A. Selvik, Lars Thomassen, Nicola Logallo, Halvor Næss Tags: Original Articles Source Type: research