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Total 202604 results found since Jan 2013.

Changes in the triglyceride glucose-body mass index estimate the risk of stroke in middle-aged and older Chinese adults: a nationwide prospective cohort study
Stroke was reported to be highly correlated with the triglyceride glucose-body mass index (TyG-BMI). Nevertheless, literature exploring the association between changes in the TyG-BMI and stroke incidence is sc...
Source: Cardiovascular Diabetology - September 16, 2023 Category: Cardiology Authors: Rong-Rui Huo, Lu Zhai, Qian Liao and Xue-Mei You Tags: Research Source Type: research

Prevalence, pattern, and correlates of dyslipidemia in Bangladeshi individuals
Stroke and ischaemic heart disease accounted for the top two causes of death in Bangladesh1. Dyslipidemia is identified as a significant independent modifiable risk factor for cardiovascular diseases (CVDs) that has been strongly connected to the pathophysiology of CVDs2. Dyslipidemia is defined as the presence of abnormal blood concentrations of one or more of the following lipids (fat): total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C), and triglycerides (TG)3.
Source: Journal of Clinical Lipidology - September 16, 2023 Category: Lipidology Authors: Md Tauhidul Islam, Md Taqbir Us Samad Talha, Sabit Saad Shafiq, Tapas Mazumder, Rajat Das Gupta, Shahjahan Siraj Tags: Original Research Source Type: research

Brain Pathology in COVID-19: Clinical Manifestations and Potential Mechanisms
AbstractNeurological manifestations of coronavirus disease 2019 (COVID-19) are less noticeable than the respiratory symptoms, but they may be associated with disability and mortality in COVID-19. Even though Omicron caused less severe disease than Delta, the incidence of neurological manifestations is similar. More than 30% of patients experienced “brain fog”, delirium, stroke, and cognitive impairment, and over half of these patients presented abnormal neuroimaging outcomes. In this review, we summarize current advances in the clinical findings of neurological manifestations in COVID-19 patients and compare them with ...
Source: Neuroscience Bulletin - September 16, 2023 Category: Neuroscience Source Type: research

Mouse model hints at pharmacogenomic strategies for stroke treatment in patients possessing a risk variant
Source: Journal of Clinical Investigation - September 15, 2023 Category: Biomedical Science Authors: Douglas E. Vaughan Source Type: research

The predominant PAR4 variant in individuals of African ancestry worsens murine and human stroke outcomes
Protease-activated receptor 4 (PAR4) (gene F2RL3) harbors a functional dimorphism, rs773902 A/G (encoding Thr120/Ala120, respectively) and is associated with greater platelet aggregation. The A allele frequency is more common in Black individuals, and Black individuals have a higher incidence of ischemic stroke than White individuals. However, it is not known whether the A allele is responsible for worse stroke outcomes. To directly test the in vivo effect of this variant on stroke, we generated mice in which F2rl3 was replaced by F2RL3, thereby expressing human PAR4 (hPAR4) with either Thr120 or Ala120. Compared with hPAR...
Source: Journal of Clinical Investigation - September 15, 2023 Category: Biomedical Science Authors: Frederik Denorme, Nicole D. Armstrong, Michelle L. Stoller, Irina Portier, Emilia A. Tugolukova, Rikki M. Tanner, Emilie Montenont, Seema Bhatlekar, Mark Cody, John L. Rustad, Abigail Ajanel, Neal D. Tolley, Darian C. Murray, Julie L. Boyle, Marvin T. Nie Source Type: research

Platelet glycoprotein IIb/IIIa inhibitor tirofiban in clopidogrel-na ïve patients undergoing elective percutaneous coronary intervention
CONCLUSION: Ad-hoc PCI in clopidogrel-naïve patients who were treated with high-dose bolus of tirofiban followed by a clopidogrel loading dose immediately after the procedure appeared to be safe.PMID:37713051 | DOI:10.1007/s12471-023-01810-2
Source: Netherlands Heart Journal - September 15, 2023 Category: Cardiology Authors: Zarina Habibi Jasper Luijkx Ben C G Gho Mustafa Ilhan Leo F Veenstra Lex A W Ruiters Mera Stein Arnoud W J van 't Hof Saman Rasoul Source Type: research

Off-Label Reduced Dose Apixaban in Older Adults With Atrial Fibrillation and Associated Outcomes
CONCLUSION AND RELEVANCE: Older adults with nonvalvular AF are commonly prescribed lower-than-recommended doses of apixaban. However, no significant association was found between empiric off-label reduced dosing and stroke or bleeding outcomes.PMID:37712551 | DOI:10.1177/10600280231199137
Source: The Annals of Pharmacotherapy - September 15, 2023 Category: Drugs & Pharmacology Authors: Ashley M Campbell Elizabeth Pae Eunice Lee Timothy Jacisin Alina Price Jessica DeAngelo Source Type: research

Report on Cardiovascular Health and Diseases in China 2022: an Updated Summary
Biomed Environ Sci. 2023 Aug 20;36(8):669-701. doi: 10.3967/bes2023.106.ABSTRACTIn the past 30 years, the accessibility and quality index of medical care have made remarkable progress in China, ranking the first among middle-income countries. Many cardiovascular technologies are at or near the world's leading level, and significant progress has been achieved in China solving the problem of "treatment difficulty" of cardiovascular diseases (CVD). However, due to the prevalence of unhealthy lifestyles among Chinese residents, a huge population with CVD risk factors, accelerated population aging, and other reasons, the incide...
Source: Biomedical and Environmental Sciences : BES - September 15, 2023 Category: Biomedical Science Authors: Writing Committee Of The Report On Cardiovascular Health And Diseases In China The Source Type: research

Short Versus Long Duration of Dual Antiplatelet Therapy After Second-Generation Drug-Eluting Stents Implantation in Patients with Diabetes
CONCLUSION: This meta-analysis showed no statistically significant benefit of longer DAPT over shorter DAPT therapy in patients undergoing PCI with drug-eluting stent in patients with diabetes.PMID:37713685 | DOI:10.1097/MJT.0000000000001519
Source: Atherosclerosis - September 15, 2023 Category: Cardiology Authors: Manesh Kumar Gangwani Muhammad Aziz Paul Chacko Asif Mahmood Muhammad Ali Fnu Priyanka Siraj Munir Abeer Aziz Shazib Sagheer Wade Lee-Smith Om Parkash Devesh Rai Bipul Baibhav Wilbert S Aronow Source Type: research

Computed tomography angiography-based radiomics model to identify high-risk carotid plaques
CONCLUSIONS: The combined model of the radiomics features of carotid plaques and PVAT and the traditional CTA features significantly contributes to identifying high-risk carotid plaques compared with traditional CTA model.PMID:37711840 | PMC:PMC10498225 | DOI:10.21037/qims-23-158
Source: Atherosclerosis - September 15, 2023 Category: Cardiology Authors: Chao Chen Wei Tang Yong Chen Wenhan Xu Ningjun Yu Chao Liu Zenghui Li Zhao Tang Xiaoming Zhang Source Type: research

Oral microbiome mediated inflammation, a potential inductor of vascular diseases: a comprehensive review
Front Cardiovasc Med. 2023 Aug 30;10:1250263. doi: 10.3389/fcvm.2023.1250263. eCollection 2023.ABSTRACTThe dysbiosis of the oral microbiome and vascular translocation of the periodontopathic microorganism to peripheral blood can cause local and systemic extra-oral inflammation. Microorganisms associated with the subgingival biofilm are readily translocated to the peripheral circulation, generating bacteremia and endotoxemia, increasing the inflammation in the vascular endothelium and resulting in endothelial dysfunction. This review aimed to demonstrate how the dysbiosis of the oral microbiome and the translocation of oral...
Source: Atherosclerosis - September 15, 2023 Category: Cardiology Authors: Diego F Gualtero Gloria In és Lafaurie Diana Marcela Buitrago Yormaris Castillo Paula Katherine Vargas-Sanchez Diana Marcela Castillo Source Type: research

Steady solution and its stability of a mathematical model of diabetic atherosclerosis
J Biol Dyn. 2023 Dec;17(1):2257734. doi: 10.1080/17513758.2023.2257734.ABSTRACTAtherosclerosis is a leading cause of death worldwide. Making matters worse, nearly 463 million people have diabetes, which increases atherosclerosis-related inflammation. Diabetic patients are twice as likely to have a heart attack or stroke. In this paper, we consider a simplified mathematical model for diabetic atherosclerosis involving LDL, HDL, glucose, insulin, free radicals (ROS), β cells, macrophages and foam cells, which satisfy a system of partial differential equations with a free boundary, the interface between the blood flow and th...
Source: Atherosclerosis - September 15, 2023 Category: Cardiology Authors: Xuming Xie Source Type: research

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