Query: stroke

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Comparison of risk of stroke in patients treated with peritoneal dialysis and hemodialysis: a systematic review and meta-analysis.
Conclusions: We observed that PD patients were less likely to develop hemorrhagic stroke than HD patients, and the risk for ischemic stroke was significantly higher for PD patients than for HD patients among the non-Asian patients. However, our findings could be biased due to the heterogeneity of the included studies. PMID: 31296101 [PubMed - in process]
Source: Renal Failure - July 14, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Factors associated with delayed presentation at the emergency department in patients with acute ischemic stroke.
Conclusions: A considerable proportion of patients with acute ischemic stroke arrives at the ED after the 4.5-h threshold for performing intravenous thrombolysis. Non-smokers, patients with a family history of CVD, with moderately severe stroke and those who use the EMS are more likely to arrive on time. PMID: 31293186 [PubMed - as supplied by publisher]
Source: Brain Injury - July 13, 2019 Category: Neurology Tags: Brain Inj Source Type: research

Cerebellar contribution to vocal emotion decoding: Insights from stroke and neuroimaging
Publication date: Available online 12 July 2019Source: NeuropsychologiaAuthor(s): Marine Thomasson, Arnaud Saj, Damien Benis, Didier Grandjean, Frédéric Assal, Julie PéronAbstractWhile the role of the cerebellum in emotion recognition has been explored with facial expressions, its involvement in the auditory modality (i.e., emotional prosody) remains to be demonstrated. The present study investigated the recognition of emotional prosody in 15 patients with chronic cerebellar ischaemic stroke and 15 matched healthy controls, using a validated task, as well as clinical, motor, neuropsychological, and psychiatric assessmen...
Source: Neuropsychologia - July 13, 2019 Category: Neurology Source Type: research

The Author's Reply: Cerebellar Stroke-like Lesions?
Authors: Muramatsu D, Yamaguchi H, Iwasa K, Yamada M PMID: 31292407 [PubMed - as supplied by publisher]
Source: Internal Medicine - July 13, 2019 Category: Internal Medicine Tags: Intern Med Source Type: research

Cerebellar Stroke-like Lesions?
Authors: Josef F PMID: 31292385 [PubMed - as supplied by publisher]
Source: Internal Medicine - July 13, 2019 Category: Internal Medicine Tags: Intern Med Source Type: research

Poststroke seizures as stroke mimics: Clinical assessment and management
This article is part of the Special Issue “Seizures & Stroke”.
Source: Epilepsy and Behavior - July 13, 2019 Category: Neurology Source Type: research

Higher Coated-Platelet Levels in Acute Stroke are Associated with Lower Cognitive Scores at Three Months Post Infarction
We examined whether coated-platelet levels measured at the time of the stroke correlate with cognitive scores at 3 months following the brain infarction. Methods: Coated-platelets were assayed in consecutive patients with nonlacunar stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - July 13, 2019 Category: Neurology Authors: Angelia C. Kirkpatrick, Julie A. Stoner, George L. Dale, Meheroz Rabadi, Calin I. Prodan Source Type: research

Randomized Controlled Trial of Gait Training Using Gait Exercise Assist Robot (GEAR) in Stroke Patients with Hemiplegia
This trial aimed to validate the effectiveness of using the Gait Exercise Assist Robot (GEAR) in patients with hemiplegia after primary stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - July 13, 2019 Category: Neurology Authors: Ken Tomida, Shigeru Sonoda, Satoshi Hirano, Akira Suzuki, Genichi Tanino, Kenji Kawakami, Eiichi Saitoh, Hitoshi Kagaya Source Type: research

Association between Bilateral Infarcts Pattern and Detection of Occult Atrial Fibrillation in Embolic Stroke of Undetermined Source (ESUS) Patients with Insertable Cardiac Monitor (ICM)
Increasingly, insertable cardiac monitors (ICM) have been used to detect Atrial Fibrillation (AF) in patients with cryptogenic stroke or embolic strokes of undetermined source (ESUS). We aim to examine the characteristics of these patients who were subsequently found to have AF.
Source: Journal of Stroke and Cerebrovascular Diseases - July 13, 2019 Category: Neurology Authors: Boi Yushan, Benjamin Y.Q. Tan, Nicholas Jinghao Ngiam, Bernard P.L. Chan, Teoh Hock Luen, Vijay K. Sharma, Ching-Hui Sia, Mayank Dalakoti, Seow Swee Chong, Pipin Kojodjojo, Leonard L.L. Yeo Source Type: research

Survey of the Erythrocyte EPA+DHA Levels in the Heart Attack/Stroke Belt
There is a clear geographical disparity in risk for cardiovascular disease (CVD) in the US, with a “heart attack/stroke belt” (hereafter the CVD belt) located primarily in the south east/central region (Figure 1). Low omega-3 fatty acid levels in the blood are known to be a risk factor for CVD independent of traditional lipid and inflammatory biomarkers, blood pressure, diabetes and smoking s tatus [1-6]. The extent to which a relatively low omega-3 levels contributes to this increased risk in this region is unknown.
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - July 13, 2019 Category: Biomedical Science Authors: W.S. Harris, K.H. Jackson, J.T. Brenna, J.C. Rodriguez, N.L. Tintle, L. Cornish Source Type: research

Efficacy of Combining Proximal Balloon Guiding Catheter and Distal Access Catheter in Thrombectomy with Stent Retriever for Anterior Circulation Ischemic Stroke.
CONCLUSION: The combined technique needs lesser attempts, decreases distal migration, increases TICI 3 reperfusion and achieves better clinical outcomes. PMID: 31290296 [PubMed]
Source: Journal of Korean Neurosurgical Society - July 12, 2019 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

Characteristics of intensity-based physical activity according to gait ability in people hospitalized with subacute stroke: a cross-sectional study.
CONCLUSION: During daytime and non-therapy time, the results suggested that gait independence is related to LIPA rather than gait speed, and gait speed and gait independence is related to MVPA. PMID: 31289708 [PubMed]
Source: Physical Therapy - July 12, 2019 Category: Physiotherapy Authors: Shimizu N, Hashidate H, Ota T, Suzuki T, Yatsunami M Tags: Phys Ther Res Source Type: research

The effect of electrical stimulation on impairment of the painful post-stroke shoulder.
Conclusion: This pilot study is the first to measure pain-free passive range of motion during electrical stimulation. Our findings demonstrate the lack of an acute effect of TENS and t-NMES on pain reduction. PMID: 31298627 [PubMed - as supplied by publisher]
Source: Topics in Stroke Rehabilitation - July 12, 2019 Category: Neurology Authors: Whitehair VC, Chae J, Hisel T, Wilson RD Tags: Top Stroke Rehabil Source Type: research

Comparing Outcomes of Patients With Idiopathic Subarachnoid Hemorrhage by Stratifying Perimesencephalic Bleeding Patterns
Background: To determine the clinical outcomes of perimesencephalic subarachnoid hemorrhages based on the computed tomography (CT) bleeding patterns. Methods: This retrospective cohort study included: (1) patients ( ≥18 years) admitted to a comprehensive stroke center (January 2015-May 2018), (2) with angiography-negative, nontraumatic subarachnoid hemorrhage in a perimesencephalic or diffuse bleeding pattern, and (3) had CT imaging performed in less than rqual to 72 hours of symptom onset. Patients were stra tified by location of bleeding on CT: Peri-1: focal prepontine hemorrhage; Peri-2: prepontine with suprasellar ci...
Source: Journal of Stroke and Cerebrovascular Diseases - July 12, 2019 Category: Neurology Authors: Benjamin Atchie, Constance McGraw, Kathryn McCarthy, Rebecca van Vliet, Donald Frei, Alicia Bennett, Russell Bartt, Alessandro Orlando, Jeffrey Wagner, David Bar-Or Source Type: research

Integration of Real-Time Electronic Health Records and Wireless Technology in a Mobile Stroke Unit
Background: UCHealth's Mobile Stroke Unit (MSU) at University of Colorado Hospital is an ambulance equipped with a computed tomography (CT) scanner and tele-stroke capabilities that began clinical operation in Aurora, Colorado January 2016. As one of the first MSU's in the United States, it was necessary to design unique and dynamic information technology infrastructure. This includes high-speed cellular connectivity, Health Insurance Portability and Accountability Act compliance, cloud-based and remote access to electronic medical records (EMR), and reliable and rapid image transfer.
Source: Journal of Stroke and Cerebrovascular Diseases - July 12, 2019 Category: Neurology Authors: Brandi Schimpf, Kathy Deanda, David A. Severenuk, Tara M. Montgomery, Gregory D. Cooley, Robert G. Kowalski, Daniel Vela-Duarte, William J. Jones Source Type: research

Left Atrial Appendage Closure Device Implantation in Patients at Very High Risk for Stroke
Little is known about the role of left atrial appendage closure using Watchman ™ device in patients who are at very high risk for stroke.
Source: Heart Rhythm - July 12, 2019 Category: Cardiology Authors: Erika Hutt, Oussama M. Wazni, Simrat Kaur, Walid I. Saliba, Khaldoun G. Tarakji, Samir Kapadia, Jose Aguilera, Amr F. Barakat, Mouin Abdallah, Wael Jaber, Peter Rasmussen, Shazam Hussain, Ken Uchino, Dolora Wisco, Bruce D. Lindsay, Mohamed Kanj, Ayman A. Source Type: research

Deficit of Motor Skill Acquisition on the Upper Limb Ipsilesional to the Injured Hemisphere in Individuals with Stroke.
CONCLUSIONS Our findings provide evidence that individuals with stroke might have difficulty in performing visuo-spatial movements and acquiring motor skills with the ipsilateral upper limb. Improvement of ipsilesional limb function increases self-care activity in daily life. Therefore, we recommend that clinicians adopt remedial strategies for ipsilesional limbs. PMID: 31283752 [PubMed - in process]
Source: Medical Science Monitor - July 11, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Outcomes of Endovascular Thrombectomy Performed 6-24 h after Acute Stroke from Extracranial Internal Carotid Artery Occlusion.
This study investigated the outcomes of thrombectomy performed 6-24 h after stroke onset caused by extracranial ICA occlusion. Of 586 stroke patients receiving thrombectomy during the past 3 years and registered in the Tama Registry of Acute Endovascular Thrombectomy database, 24 were identified with ICA occlusion (14 extracranial and 10 intracranial), known to be well 6-24 h before presentation, and with pre-stroke modified Rankin Scale (mRS) score of 0 or 1. Clinical outcomes measured were the rate of functional independence at 90 days according to mRS score of 0-2 and 90 day mortality rate. Of patients with extracranial...
Source: Neurologia Medico-Chirurgica - July 11, 2019 Category: Neurosurgery Tags: Neurol Med Chir (Tokyo) Source Type: research

Danhong injection facilitates recovery of  post-stroke motion deficit via Parkin-enhanced mitochondrial function.
CONCLUSIONS: The overall result shows that daily intervention with DHI provides neuroprotection and survival to improve gait motion in Wistar rats. PMID: 31282440 [PubMed - as supplied by publisher]
Source: Restorative Neurology and Neuroscience - July 11, 2019 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

The protective effect of persistent trigeminal artery in patients with ischemic stroke
Almost all case reports related to persistent trigeminal artery indicated that the existence of persistent trigeminal artery may increase the risk of ischemic stroke. However our case demonstrated that the per...
Source: BMC Neurology - July 11, 2019 Category: Neurology Authors: Yicheng Xu, Yong Kong, Yahui Xu and Peifu Wang Tags: Case report Source Type: research

Implementation of a pilot electronic stroke outcome reporting system for emergency care providers
Emergency department (ED) providers and clinicians find that feedback on acute stroke patients is rewarding, valuable to professional development, and helpful for practice improvement. However, feedback is rarely provided, particularly for patients with stroke. Here we describe the implementation of an electronic stroke outcome reporting tool for providing feedback to ED providers.
Source: The American Journal of Emergency Medicine - July 11, 2019 Category: Emergency Medicine Authors: William L. Scheving, Joseph M. Ebersole, Michael Froehler, Donald Moore, Kiersten Brown-Espaillat, James Closser, Wesley H. Self, Michael J. Ward Source Type: research

Cholesterol lowering and stroke: no longer room for pleiotropic effects of statins – confirmation from PCSK9 inhibitor studies
The relationship between cholesterol levels and stroke has been much less clear than between cholesterol levels and coronary heart disease. This is likely mostly due to the inadequate power of older studies and the low intensity of cholesterol-lowering interventions at that time available. Because a reduction in stroke has been, conversely, clearly observed in trials with statins, for long “pleiotropic” effects of such drugs, unrelated to cholesterol lowering, have been invoked. In a previous analysis of all randomized trials of cholesterol-lowering treatments reporting on stroke we had, however, reached the conclusion...
Source: The American Journal of Medicine - July 11, 2019 Category: General Medicine Authors: Tanya Salvatore, Riccardo Morganti, Roberto Marchioli, Raffaele De Caterina Tags: Clinical Research Study Source Type: research

Post-Stroke Microglia Induce Sirtuin2 Expression to Suppress the Anti-inflammatory Function of Infiltrating Regulatory T Cells
AbstractIschemic stroke is among the leading causes of death and disability across the globe. Post-stroke neuroinflammation contributes to the pathophysiology of ischemic stroke in the acute phase through damaging neurons in the penumbra region. Infiltrating regulatory T cells (Treg cells) provide neuronal protection in ischemic brains. In the current study using a mouse-transient middle cerebral artery occlusion (MCAO) model, we characterized the changes of sirtuin expression in infiltrating Treg cells in the acute phase of ischemia. We found that Sirt2 was remarkably upregulated in infiltrating Treg cells at day 3 post-M...
Source: Inflammation - July 11, 2019 Category: Allergy & Immunology Source Type: research

Prevalence of Stroke in Fayoum Governorate, Egypt: A Community-Based Study
This study was designed to find out the prevalence of stroke in Fayoum Governorate& to study some associated risk factors. Methods: through this community based cross-sectional study 4784 participants aged more than or equal to 18 years old were enrolled. A multi-stage random sample technique was followed to choose the study sample.
Source: Journal of Stroke and Cerebrovascular Diseases - July 11, 2019 Category: Neurology Authors: Hala A. Shaheen, Wafaa Y. Abdel Wahed, Sharbat T. Hasaneen Source Type: research

Analysis of the association between selected factors and outcomes of treadmill gait training with biofeedback in patients with chronic stroke.
CONCLUSION: Age, duration of time from stroke onset, and sex do not affect outcomes of gait re-education based on treadmill training in patients at a chronic stage post-stroke and Brunnstrom recovery stage 3-4. Side of paresis significantly differentiates rehabilitation outcomes measured with speed test. The best scores in all the performance measures before rehabilitation were identified in the group 3-6 years after stroke. PMID: 31282393 [PubMed - as supplied by publisher]
Source: Journal of Back and Musculoskeletal Rehabilitation - July 10, 2019 Category: Orthopaedics Tags: J Back Musculoskelet Rehabil Source Type: research

Erratum to: Impact of Functional Status on Noncardioembolic Ischemic Stroke Recurrence Within 1 Year: The Korean Stroke Cohort for Functioning and Rehabilitation Study.
Authors: Kim MS, Joo MC, Sohn MK, Lee J, Kim DY, Lee SG, Shin YI, Kim SY, Oh GJ, Lee YS, Han EY, Han J, Ahn J, Chang WH, Kim YH Abstract This corrects the article on p. 54 in vol. 15, PMID: 30618217. PMID: 31286724 [PubMed - in process]
Source: Journal of Clinical Neurology - July 10, 2019 Category: Neurology Tags: J Clin Neurol Source Type: research

Intravascular lymphoma as a Potential Cause of Recurrent Embolic Stroke of Undetermined Source.
Authors: Woo KA, Yoo D, Jung KH PMID: 31286720 [PubMed]
Source: Journal of Clinical Neurology - July 10, 2019 Category: Neurology Tags: J Clin Neurol Source Type: research

Global brain inflammation in stroke
Publication date: Available online 8 July 2019Source: The Lancet NeurologyAuthor(s): Kaibin Shi, De-Cai Tian, Zhi-Guo Li, Andrew F Ducruet, Michael T Lawton, Fu-Dong ShiSummaryStroke, including acute ischaemic stroke and intracerebral haemorrhage, results in neuronal cell death and the release of factors such as damage-associated molecular patterns (DAMPs) that elicit localised inflammation in the injured brain region. Such focal brain inflammation aggravates secondary brain injury by exacerbating blood–brain barrier damage, microvascular failure, brain oedema, oxidative stress, and by directly inducing neuronal cell dea...
Source: The Lancet Neurology - July 10, 2019 Category: Neurology Source Type: research

Neuroinflammation: friend and foe for ischemic stroke
Stroke, the third leading cause of death and disability worldwide, is undergoing a change in perspective with the emergence of new ideas on neurodegeneration. The concept that stroke is a disorder solely of bl...
Source: Journal of Neuroinflammation - July 10, 2019 Category: Neurology Authors: Richard L. Jayaraj, Sheikh Azimullah, Rami Beiram, Fakhreya Y. Jalal and Gary A. Rosenberg Tags: Review Source Type: research

Long-term use of implanted peroneal functional electrical stimulation for stroke-affected gait: the effects on muscle and motor nerve
Peripheral changes to muscle and motor nerves occur following stroke, which may further impair functional capacity. We investigated whether a year-long use of an implanted peroneal FES system reverses stroke-r...
Source: Journal of NeuroEngineering and Rehabilitation - July 10, 2019 Category: Rehabilitation Authors: Frank Berenpas, Vivian Weerdesteyn, Alexander C. Geurts and Nens van Alfen Tags: Research Source Type: research

A clinical study to assess the influence of acupuncture at “Wang’s Jiaji” acupoints on limb spasticity in patients in convalescent stage of ischemic stroke: study protocol for a randomized controlled trial
Stroke is characterized by high morbidity, high mortality, and high disability. Spasticity, one of the most common complications after stroke, may reduce the potential success of rehabilitation and has a detri...
Source: Trials - July 10, 2019 Category: General Medicine Authors: Huanqin Li, Dehuai Long, Bin Li, Huilin Liu, Tingting Ma, Tingying Wu, Martin Eriksson, Yali Wen, Jia Wei, Wei You, Yinxia Liu, Xiaobai Xu, Yajie Zhang, Linpeng Wang and Jingqing Sun Tags: Study protocol Source Type: research

A comparison of benign positional vertigo and stroke patients presenting to the emergency department with vertigo or dizziness
ConclusionsImaging utilization in BPPV patients presenting with VDS is high. The profile of patients with BPPV that received imaging was substantially more benign than that of stroke patients (a quarter had no neurologic symptoms, exam findings, or stroke RFs). The HINTS exam was underutilized, and computed tomography was heavily utilized despite well-established limitations in diagnosing posterior circulation strokes. This study highlights the need for increased training in the HINTS exam, narrowing of the scope for computed tomography, and a higher threshold for imaging patients with isolated VDS.
Source: American Journal of Otolaryngology - July 10, 2019 Category: Endocrinology Source Type: research

Effect of gene –gene and gene–environment interaction on the risk of first‐ever stroke and poststroke death
ConclusionsOur findings identified two novel genetic interactions ofVKORC1 andChr.9p21.3 and ofVEGFA andKDR for risk of stroke and subtypes as well as future stroke prognosis.
Source: Molecular Genetics & Genomic Medicine - July 10, 2019 Category: Genetics & Stem Cells Authors: Congrui Feng, Yunyun Yang, Shujun Yang, Xin Tu, Yibo Wang, Yiqing Song, Rutai Hui, Weili Zhang Tags: ORIGINAL ARTICLE Source Type: research

Quality Management Program of Stroke Rehabilitation Using Adherence to Guidelines: A Nationwide Initiative in Japan
In recent years, interest in the quality of medical care has rapidly increased worldwide. However, quality indicators that contribute to establishing standard treatment in stroke medicine, especially rehabilitation, are not well-developed in Japan. Japan has established Kaifukuki (convalescent) rehabilitation wards, and the development of quality indicators for stroke rehabilitation in the convalescent phase is an urgent issue.
Source: Journal of Stroke and Cerebrovascular Diseases - July 10, 2019 Category: Neurology Authors: Seiji Miura, Ryuji Miyata, Shuji Matsumoto, Takahiro Higashi, Yoshinobu Wakisaka, Tetsuro Ago, Takanari Kitazono, Koji Iihara, Megumi Shimodozono Source Type: research

Targeted Drug Delivery to Stroke via Chemotactic Recruitment of Nanoparticles Coated with Membrane of Engineered Neural Stem Cells
Here a membrane ‐coating approach to display large transmembrane protein receptors to the surface of nanoparticles for drug delivery to the brain is developed and validated. The study also establishes a new formulation of glyburide that can be translated into clinical applications to improve clinical management of brain injuries. AbstractCell membrane coating has recently emerged as a promising biomimetic approach to engineering nanoparticles (NPs) for targeted drug delivery. However, simple cell membrane coating may not meet the need for efficient drug delivery to the brain. Here, a novel molecular engineering strategy ...
Source: Small - July 10, 2019 Category: Nanotechnology Authors: Junning Ma, Shenqi Zhang, Jun Liu, Fuyao Liu, Fenyi Du, Miao Li, Ann T. Chen, Youmei Bao, Hee Won Suh, Jonathan Avery, Gang Deng, Yu Zhou, Peng Wu, Kevin Sheth, Haijun Wang, Jiangbing Zhou Tags: Full Paper Source Type: research

Acute stroke rehabilitation for gait training with cyborg type robot Hybrid Assistive Limb: A pilot study
Robot-assisted gait training following acute stroke could allow patients with severe disability to receive a high dosage and intensity of gait training compared with conventional physical therapy (CP). However, given the limited data on gauging the efficacy of Hybrid Assistive Limb (HAL) on gait training in patients with acute stroke, we aimed to evaluate several outcome measures following gait training with HAL. Patients with first-ever stroke, who required a walking aid and were able to start gait training within 1  week of stroke onset were included in the current study.
Source: Journal of the Neurological Sciences - July 10, 2019 Category: Neurology Authors: Chiaki Yokota, Yukio Yamamoto, Masatoshi Kamada, Michikazu Nakai, Kunihiro Nishimura, Daisuke Ando, Takeo Sato, Masatoshi Koga, Masafumi Ihara, Kazunori Toyoda, Yasuyuki Fujimoto, Hirotaka Odani, Kazuo Minematsu, Takashi Nakajima Source Type: research

A Sandwich Piezoelectric Actuator with Long Stroke and Nanometer Resolution by the Hybrid of Two Actuation Modes
Publication date: Available online 8 July 2019Source: Sensors and Actuators A: PhysicalAuthor(s): Jie Deng, Weishan Chen, Kai Li, Liang Wang, Yingxiang LiuAbstractA piezoelectric actuator operating at direct actuation mode and inertial actuation mode was proposed for linear driving with long stroke, nanometer resolution and high scan rate. Different from the previous piezoelectric actuators constructed with stacked flexure structures, the proposed actuator used a sandwich structure with high resonance frequency. The operating principle was discussed. The structure was designed by the assistance of theoretical analysis and ...
Source: Sensors and Actuators A: Physical - July 9, 2019 Category: Physics Source Type: research

Hypertension and Stroke: Update on Treatment
Stroke is the second most common cause of mortality worldwide and the third most common cause of disability.1 Although there has been a global trend towards a reduction in stroke incidence, prevalence and mortality since the 1990s, the overall stroke burden in terms of absolute number of people affected continues to increase.2 More than 1 million people have a stroke every year in Europe and that figure is estimated to rise to 1.5 million by 2025, due to the ageing population.
Source: Radcliffe Cardiology - July 9, 2019 Category: Cardiology Authors: mehul Source Type: research

Status of prehospital delay and intravenous thrombolysis in the management of acute ischemic stroke in Nepal
The objective of this...
Source: BMC Neurology - July 9, 2019 Category: Neurology Authors: Gaurav Nepal, Jayant Kumar Yadav, Babin Basnet, Tirtha Man Shrestha, Ghanshyam Kharel and Rajeev Ojha Tags: Research article Source Type: research

The role of blood pressure in risk of ischemic and hemorrhagic stroke in type 1 diabetes
Hypertension is one of the strongest risk factors for stroke in the general population, while systolic blood pressure has been shown to independently increase the risk of stroke in type 1 diabetes. The aim of ...
Source: Cardiovascular Diabetology - July 9, 2019 Category: Cardiology Authors: Stefanie H ägg-Holmberg, Emma H. Dahlström, Carol M. Forsblom, Valma Harjutsalo, Ron Liebkind, Jukka Putaala, Turgut Tatlisumak, Per-Henrik Groop and Lena M. Thorn Tags: Original investigation Source Type: research

Evaluation of an OSA risk stratifying and treatment protocol during inpatient rehabilitation of post-stroke patients
ConclusionsThe use of APAP in high-risk patients was poorly tolerated and did not improve post-stroke recovery. Further studies with larger sample sizes are needed to determine the effect of APAP treatment on short-term recovery.
Source: Sleep and Breathing - July 9, 2019 Category: Respiratory Medicine Source Type: research

Stroke and Dementia Risk in Patients with and without Atrial Fibrillation and Carotid Arterial Disease
We sought to understand the risks of stroke, transient ischemic attack(TIA), and dementia in patients with and without atrial fibrillation (AF) and carotid arterial disease (CD), or a combination of both, and determine if therapies for each disease may influence risks. 11,572 patients were included and matched into 4 groups of 2,893 by the presence of AF and CD. CD and AF augment risk of stroke/TIA and dementia in the general population and the coexistence of both diseases is additive in risk. Ablation of AF was associated with lower risk, the magnitude of which was greater in those with CD.
Source: Heart Rhythm - July 9, 2019 Category: Cardiology Authors: T. Jared Bunch, Tami L. Bair, Brian G. Crandall, Michael J. Cutler, John D. Day, Kevin G. Graves, Victoria Jacobs, Charles Mallender, Jeffrey S. Osborn, J. Peter Weiss, Heidi T. May Source Type: research

Swallowing progression during the acute phase of cortical and subcortical ischemic stroke and its association with the extension of brain damage and cognitive impairment.
Conclusion: Dysphagia is a common complication in the acute phase of stroke, and is associated with the extension of brain damage and cognitive impairment. PMID: 31287384 [PubMed - as supplied by publisher]
Source: Topics in Stroke Rehabilitation - July 9, 2019 Category: Neurology Authors: Mourão AM, Vicente LCC, Abreu MNS, Tatiana Simões C, Romeu Vale S, De Souza LC, Teixeira AL Tags: Top Stroke Rehabil Source Type: research

Activation of Sigma-1 Receptor Enhanced Pericyte Survival via the Interplay Between Apoptosis and Autophagy: Implications for Blood –Brain Barrier Integrity in Stroke
This study identified the unique roles for σ-1R in mediating pericyte survival via the regulation of the interplay between apoptosis and autophagy, suggesting that a novel σ-1R agonist may be a promising therapeutic agent for the treatment of stroke patients.
Source: Translational Stroke Research - July 9, 2019 Category: Neurology Source Type: research

Use of Wearable Technology in Remote Evaluation of Acute Stroke Patients: Feasibility and Reliability of a Google Glass-Based Device
Background: Telestroke is an efficient, cost-effective way to standardize care and improve access to immediate neurologic expertise for rural hospitals and other underserved areas. Hands-free wearable technology potentially allows for faster evaluations that fit easily within prehospital workflows and could improve prehospital triage of stroke patients to appropriate receiving stroke centers. The goal of this study is to assess the feasibility and inter-rater reliability of wearable eyeglass video technology in assessing stroke-related neurologic deficits in patients with suspected acute stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - July 9, 2019 Category: Neurology Authors: Ali Reza Noorian, Mersedeh Bahr Hosseini, Gilda Avila, Richard Gerardi, Anne-Fleur Andrle, Michael Su, Sidney Starkman, Jeffrey L. Saver, Latisha K. Sharma Source Type: research

Application of Neck Circumference in Four-Variable Screening Tool for Early Prediction of Obstructive Sleep Apnea in Acute Ischemic Stroke Patients
Background: The purpose of this study was to validate and pilot the use of the four-variable screening tool (4V) and modified 4V tools to identify acute ischemic stroke and transient ischemic attack (TIA) patients at high risk of obstructive sleep apnea (OSA). Methods: Two modified scales, 4V-1 (ie, using neck circumference instead body mass index, regardless of gender) and 4V-2 (ie, as above but scored differently according to gender) were designed. These tools were used in a consecutive cohort of 124 acute ischemic stroke/TIA patients, together with the 4V-1, 4V-2, 4V, as well as the STOP-BANG, the Berlin questionnaire, ...
Source: Journal of Stroke and Cerebrovascular Diseases - July 9, 2019 Category: Neurology Authors: Lisan Zhang, Tingting Zeng, Yaxing Gui, Yi Sun, Fei Xie, Dan Zhang, Xingyue Hu Source Type: research

Evaluating the Effect of Comprehensive Intervention on Cerebro-Vascular Function in Population at High Risk of Stroke
Background: Today there exists few intervention researches on cerebro-vascular function in populations at high risk of stroke in China. Methods: Patients more than 40 years old, with at least 1 of stroke risk factors were recruited from outpatient department in 3 hospitals. A quasi-experimental design was performed by assigning participants into 3 groups: comprehensive intervention group, health education group, and control group. Participants in the control group received no intervention but were informed of risk factors of stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - July 9, 2019 Category: Neurology Authors: Xiangxiang Liu, Yaohua Gu, Yuting Zhang, Yanan Zhang, Xiaodong Tan Source Type: research

A meta-analysis on associations of IL-6 and IL-10 polymorphisms with susceptibility to ischemic stroke
Some previous studies already explored associations of interleukin-6 (IL-6) and interleukin-10 (IL-10) polymorphisms with ischemic stroke (IS). However, the results were conflicting. In this meta-analysis, we aimed to better analyze the relationship between IL-6/IL-10 polymorphisms and IS in a larger pooled population.
Source: Journal of Neuroimmunology - July 9, 2019 Category: Allergy & Immunology Authors: Miao Chen, Yue Yang Source Type: research

Neuroprotection by Exogenous and Endogenous Neuregulin-1 in Mouse Models of Focal Ischemic Stroke
In this study, we examined neuroprotection by exogenous and endogenous NRG-1 using a mouse model of ischemic stroke. C57BL6 mice were subjected to middle cerebral artery occlusion (MCAO) followed by reperfusion. NRG-1 or vehicle was infused intra-arterially (i.a.) or intravenously (i.v.) after MCAO and before the onset of reperfusion. NRG-1 treatment (16  μg/kg; i.a.) reduced cerebral cortical infarct volume by 72% in mice when delivered post-ischemia. NRG-1 also inhibited neuronal injury as measured by Fluoro Jade B labeling and rescued NeuN immunoreactivity in neurons. Neuroprotection by NRG-1 was also observed in mice...
Source: Journal of Molecular Neuroscience - July 9, 2019 Category: Neuroscience Source Type: research