Pathology Review After Splenectomy Often Unnecessary Pathology Review After Splenectomy Often Unnecessary
The vast majority of tissue reviews in patients who have undergone trauma-related splenectomy reveal no new medical conditions, new research shows, leading some to suggest that guidelines be amendedMedscape Medical News (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - August 19, 2021 Category: Surgery Tags: Pathology & Lab Medicine News Source Type: news
A leukotriene-dependent spleen-liver axis drives TNF production in systemic inflammation
Production of the proinflammatory cytokine tumor necrosis factor (TNF) must be precisely regulated for effective host immunity without the induction of collateral tissue damage. Here, we showed that TNF production was driven by a spleen-liver axis in a rat model of systemic inflammation induced by bacterial lipopolysaccharide (LPS). Analysis of cytokine expression and secretion in combination with splenectomy and hepatectomy revealed that the spleen generated not only TNF but also factors that enhanced TNF production by the liver, the latter of which accounted for nearly half of the TNF secreted into the circulation. Using...
Source: Signal Transduction Knowledge Environment - April 20, 2021 Category: Science Authors: Fonseca, M. T., Moretti, E. H., Marques, L. M. M., Machado, B. F., Brito, C. F., Guedes, J. T., Komegae, E. N., Vieira, T. S., Festuccia, W. T., Lopes, N. P., Steiner, A. A. Tags: STKE Research Articles Source Type: news
A single-center prospective cohort study on postsplenectomy sepsis and its prevention
This study evaluated the impact of a dedicated outpatient service on vaccination uptake after splenectomy and on the incidence of postsplenectomy sepsis. Methods. From 2009 to 2016 at the University Hospital Freiburg (Germany), asplenic patients were referred to a dedicated outpatient service, provided with comprehensive preventive care including vaccinations, and enrolled in a prospective cohort study. The impact of the service on vaccination uptake and the occurrence of severe sepsis/septic shock was compared between patients who had splenectomy (or were asplenic) within 3 months of study entry ( " early study entry " ) ...
Source: Current Awareness Service for Health (CASH) - October 9, 2020 Category: Consumer Health News Source Type: news
How Long Does It Take to Recover From a Splenectomy?
Title: How Long Does It Take to Recover From a Splenectomy?Category: Procedures and TestsCreated: 7/1/2020 12:00:00 AMLast Editorial Review: 7/1/2020 12:00:00 AM (Source: MedicineNet Digestion General)
Source: MedicineNet Digestion General - July 1, 2020 Category: Nutrition Source Type: news
Falling Splenectomy Rates in ITP Raise Questions Over Role Falling Splenectomy Rates in ITP Raise Questions Over Role
Splenectomy is being performed less and less often in immune thrombocytopenia due to the increased availability of medical therapies, resulting in a lower benefit of the procedure to patients, suggests UK data.Medscape News UK (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - May 11, 2020 Category: Allergy & Immunology Tags: Hematology-Oncology News Source Type: news
Guidance on shielding for Children and Adults with splenectomy or splenic dysfunction during the COVID-19 pandemic, BSH
This document aims to provide a clear and consistent summary of the recommendations as to which patients with splenectomy or functional asplenia should be classed as being at high risk of developing Covid-19-related complications and, as a consequence, be placed on the Shielded Patient List (SPL). (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - May 7, 2020 Category: Consumer Health News Source Type: news
U-turn as splenectomy patients added to COVID-19 shielding list
Patients who have undergone a splenectomy have been added to the COVID-19 shielding list, NHS England has confirmed, reversing its previous advice. (Source: GP Online News)
Source: GP Online News - April 24, 2020 Category: Primary Care Tags: Coronavirus Source Type: news
Later Onset of Infections After Splenectomy Seen With Vaccination Later Onset of Infections After Splenectomy Seen With Vaccination
Vaccination is associated with later onset of infection in adults who undergo splenectomy, according to findings from the Rochester (Minnesota) Epidemiology Project (REP).Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - September 3, 2019 Category: Consumer Health News Tags: General Surgery News Source Type: news
A 52-Year-Old Woman With Splenomegaly
A 52-year-old woman presents with abdominal discomfort, which on physical examination revealed the presence of splenomegaly. A splenectomy is performed. What is your diagnosis? (Source: CancerNetwork)
Source: CancerNetwork - April 4, 2019 Category: Cancer & Oncology Authors: Cesar A. Moran, MD Source Type: news
Amgen Submits Supplemental Biologics License Application For Nplate ® (romiplostim)
Application Seeks to Include Adult Patients who Have had Immune Thrombocytopenia for 12 Months or Less
THOUSAND OAKS, Calif., Dec. 19, 2018 /PRNewswire/ -- Amgen (NASDAQ:AMGN) today announced the submission of a Supplemental Biologics License Application (sBLA) to the U.S. Food and Drug Administration (FDA) for Nplate® (romiplostim) to include the treatment of adult patients with immune thrombocytopenia (ITP) who have had ITP for 12 months or less and an insufficient response to corticosteroids, immunoglobulins or splenectomy.
"Patients living with ITP need more flexibility in their treatment options, and we believe...
Source: Amgen News Release - December 19, 2018 Category: Pharmaceuticals Tags: Uncategorized Source Type: news
FDA Approves Nplate ® (Romiplostim) For Use In Pediatric Patients With Immune Thrombocytopenia
Application Granted Priority Review Designation
Approval Based on Results That Demonstrated Nplate Successfully Increased and Sustained Platelet Counts in Children Affected by Rare Blood Disorder THOUSAND OAKS, Calif., Dec. 14, 2018 /PRNewswire/ -- Amgen (NASDAQ:AMGN) today announced that the U.S. Food and Drug Administration (FDA) has approved the supplemental Biologics License Application (sBLA) for Nplate® (romiplostim) for the treatment of pediatric patients one year of age and older with immune thrombocytopenia (ITP) for at least six months who have had an insufficient response to corticosteroids, immunoglobuli...
Source: Amgen News Release - December 14, 2018 Category: Pharmaceuticals Tags: Uncategorized Source Type: news
Ruptured Spleen Samples in Patients With Mononucleosis Ruptured Spleen Samples in Patients With Mononucleosis
Histology of splenectomy specimens removed after spontaneous rupture due to infectious mononucleosis may resemble that of malignant lymphoma.American Journal of Clinical Pathology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 8, 2018 Category: Consumer Health News Tags: Pathology & Lab Medicine Journal Article Source Type: news
Low Booster Vaccination Rates After Trauma Splenectomy Low Booster Vaccination Rates After Trauma Splenectomy
Timely booster vaccination rates are very low after trauma splenectomy, according to a study of medical records.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - December 21, 2017 Category: Consumer Health News Tags: General Surgery News Source Type: news
A 25-Year-Old Man With Injuries From a Vehicle Accident A 25-Year-Old Man With Injuries From a Vehicle Accident
A 25-year-old man presents after sustaining extensive injuries in a motor vehicle accident. After splenectomy, which functions are likely to be deficient in this patient?Osmosis (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 17, 2017 Category: Consumer Health News Tags: Med Students Interactive Quiz Source Type: news
The Spleen The Spleen
This article reviews the importance of splenic pathology and the implications of concurrent disease in a variety of clinical situations.BJA Education (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 26, 2017 Category: Consumer Health News Tags: General Surgery Journal Article Source Type: news
