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MDA-7/IL-24 Alters Bcl-x RNA Splicing RNA
Melanoma differentiation-associated gene 7 (MDA-7/IL-24) exhibits cytotoxic effects on tumor cells while sparing untransformed cells, and Bcl-x(L) is reported to efficiently block the induction of cell death by MDA-7/IL-24. The expression of Bcl-x(L) is regulated at the level of RNA splicing via alternative 5′ splice site selection within exon 2 to produce either the pro-apoptotic Bcl-x(s) or the anti-apoptotic Bcl-x(L). Our laboratory previously reported that Bcl-x RNA splicing is dysregulated in a large percentage of human non-small cell lung cancer (NSCLC) tumors. Therefore, we investigated whether the alternative RNA...
Source: Journal of Biological Chemistry - October 6, 2016 Category: Chemistry Authors: Shapiro, B. A., Vu, N. T., Shultz, M. D., Shultz, J. C., Mietla, J. A., Gouda, M. M., Yacoub, A., Dent, P., Fisher, P. B., Park, M. A., Chalfant, C. E. Tags: Signal Transduction Source Type: research
