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Yangonin protects against estrogen-induced cholestasis in a farnesoid X receptor-dependent manner.
In conclusion, yangonin alleviates estrogen-induced cholestasis, due to FXR-mediated gene regulation. PMID: 31220436 [PubMed - as supplied by publisher]
Source: European Journal of Pharmacology - June 16, 2019 Category: Drugs & Pharmacology Authors: Dong R, Wang J, Gao X, Wang C, Liu K, Wu J, Liu Z, Sun H, Ma X, Meng Q Tags: Eur J Pharmacol Source Type: research

Licorice Root Components in Dietary Supplements are Selective Estrogen Receptor Modulators with a Spectrum of Estrogenic and Anti-Estrogenic Activities
Publication date: Available online 26 November 2015 Source:Steroids Author(s): Nittaya Boonmuen, Ping Gong, Zulfiqar Ali, Amar G. Chittiboyina, Ikhlas Khan, Daniel R. Doerge, William G. Helferich, Kathryn E. Carlson, Teresa Martin, Pawinee Piyachaturawat, John A. Katzenellenbogen, Benita S. Katzenellenbogen Licorice root extracts are often consumed as botanical dietary supplements by menopausal women as a natural alternative to pharmaceutical hormone replacement therapy. In addition to their components liquiritigenin (Liq) and isoliquiritigenin (Iso-Liq), known to have estrogenic activity, licorice root extra...
Source: Steroids - November 27, 2015 Category: Drugs & Pharmacology Source Type: research

Follicle-stimulating hormone induces postmenopausal dyslipidemia through inhibiting hepatic cholesterol metabolism.
CONCLUSIONS: FSH may interact with its receptors in hepatocytes and reduce LDLR levels, which subsequently attenuates the endocytosis of LDL-C, resulting in an elevated circulating LDL-C level. PMID: 26583582 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - November 19, 2015 Category: Endocrinology Authors: Song Y, Wang ES, Xing LL, Shi S, Qu F, Zhang D, Li JY, Shu J, Meng Y, Sheng JZ, Zhou JH, Huang HF Tags: J Clin Endocrinol Metab Source Type: research

GR-mediated Regulation of Cytokine Genes by MPA Signal Transduction
This study shows that P4 and MPA significantly increase the expression of the IL-12p40 and IL-12p35 genes, whereas IL-10 gene expression is suppressed in a dose-dependent manner. Moreover, these effects were abrogated when reducing the glucocorticoid receptor (GR) levels with siRNA. Using a combination of chromatin immunoprecipitation (ChIP), siRNA, and re-ChIP assays, we show that recruitment of the P4- and MPA-bound GR to the IL-12p40 promoter requires CCAAT enhancer-binding protein (C/EBP)-β and nuclear factor κB (NFκB), although recruitment to the IL-10 promoter requires signal transducer and activator of transcript...
Source: Journal of Biological Chemistry - November 6, 2014 Category: Chemistry Authors: Louw-du Toit, R., Hapgood, J. P., Africander, D. Tags: Gene Regulation Source Type: research

Phytoestrogen-Induced Apoptosis
Phytoestrogens have been investigated as natural alternatives to hormone replacement therapy and their potential as chemopreventive agents. We investigated the effects of equol, genistein, and coumestrol on cell growth in fully estrogenized MCF7 cells, simulating the perimenopausal state, and long-term estrogen-deprived MCF7:5C cells, which simulate the postmenopausal state of a woman after years of estrogen deprivation, and compared the effects with that of steroidal estrogens: 17β estradiol (E2) and equilin present in conjugated equine estrogen. Steroidal and phytoestrogens induce proliferation of MCF7 cells at phys...
Source: Cancer Prevention Research - September 1, 2014 Category: Cancer & Oncology Authors: Obiorah, I. E., Fan, P., Jordan, V. C. Tags: Preclinical Intervention, Preclinical Intervention: In Vivo (Animals): Drugs, Nutritional Interventions, Mechanisms Research Articles Source Type: research

Oestrogen induced downregulation of TFPI expression is mediated by ERα
Conclusion: Our data establish a direct and time dependent regulation of TFPI expression by oestrogens through the ERα at the transcriptional level.
Source: Thrombosis Research - April 30, 2014 Category: Hematology Authors: Huda Omar Ali, Benedicte Stavik, Elisabeth Dørum, Nina Iversen, Per Morten Sandset, Grethe Skretting Tags: Coagulation and Fibrinolysis Source Type: research