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Specialty: Intensive Care
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Total 3 results found since Jan 2013.
Y-Chromosome Gene, < em > Uty < /em > , Protects Against Pulmonary Hypertension by Reducing Proinflammatory Chemokines
CONCLUSIONS: Uty, is protective against PH. Reduction of Uty expression results in increased expression of proinflammatory chemokines CXCL9 and CXCL10 which trigger endothelial cell death and PH. Inhibition of Cxcl9 and Cxcl10 rescues PH development in multiple experimental models.PMID:35504005 | DOI:10.1164/rccm.202110-2309OC
Source: Am J Respir Crit Car... - May 3, 2022 Category: Intensive Care Authors: Christine M Cunningham Min Li Gregoire Ruffenach Mitali Doshi Laila Aryan Jason Hong John Park Haley Hrncir Lejla Medzikovic Soban Umar Arthur P Arnold Mansoureh Eghbali Source Type: research
Fragile Histidine Triad (FHIT), a Novel Modifier Gene in Pulmonary Arterial Hypertension.
CONCLUSIONS: This study highlights the importance of the novel BMPR2 modifier FHIT in PH and the clinical value of the repurposed drug Enzastaurin as a potential novel therapeutic strategy to improve PAH.
PMID: 30107138 [PubMed - as supplied by publisher]
Source: Am J Respir Crit Car... - August 14, 2018 Category: Intensive Care Authors: Dannewitz Prosseda S, Tian X, Kuramoto K, Boehm M, Sudheendra D, Miyagawa K, Zhang F, Solow-Cordero D, Saldivar JC, Austin ED, Loyd JE, Wheeler L, Andruska A, Donato M, Wang L, Huebner K, Metzger RJ, Khatri P, Spiekerkoetter E Tags: Am J Respir Crit Care Med Source Type: research
