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Cationic dendritic starch as a vehicle for photodynamic therapy and siRNA co-delivery
This study demonstrates the versatility of cESG as a platform for dual delivery of small molecules and oligonucleotides, and the potential for further development of this system in combination therapy applications. Graphical abstract
Source: Journal of Photochemistry and Photobiology B: Biology - February 20, 2017 Category: Speech Therapy Source Type: research

UVB-dependent changes in the expression of fast-responding early genes is modulated by huCOP1 in keratinocytes
In this study, we report that stable siRNA-mediated silencing of huCOP1 affects the UVB response of several genes within 2h of irradiation, indicating that altered huCOP1 expression sensitizes the cells toward UVB. Pathway analysis identified a molecular network in which 13 of the 30 examined UVB-regulated genes were organized around three central proteins. Since the expression of the investigated genes was upregulated by UVB in the siCOP1 cell line, we hypothesize that huCOP1 is a repressor of the identified pathway. Several members of the network have been implicated previously in the pathogenesis of non-melanoma skin ca...
Source: Journal of Photochemistry and Photobiology B: Biology - November 7, 2014 Category: Speech Therapy Source Type: research