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Radiation Induces Bone Microenvironment Disruption by Activating the STING-TBK1 Pathway
Conclusions: The STING-P-TBK1 signaling pathway plays a crucial role in the regulation of the secretion of inflammatory cytokines and osteoclastogenesis potential in IR-induced bone microenvironment disruption. The selective STING antagonist can be used to intervene to block the STING pathway and, thereby, repair IR-induced multicellular biological damage and mitigate the imbalance between osteoclastogenesis and osteoblastgenesis.PMID:37512126 | PMC:PMC10386124 | DOI:10.3390/medicina59071316
Source: Medicina (Kaunas) - July 29, 2023 Category: Universities & Medical Training Authors: Yuyang Wang Li Ren Linshan Xu Jianping Wang Jianglong Zhai Guoying Zhu Source Type: research
