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Cannabidiol attenuates methamphetamine-induced conditioned place preference in male rats and viability in PC12 cells through the Sigma1R/AKT/GSK3 β/CREB signaling pathway
Conclusions: Cannabidiol seems to inhibit the rewarding effects of methamphetamine and the effects of this drug on cell viability. Sigma1R should be given further consideration as a potential target for cannabidiol.PMID:35881880 | DOI:10.1080/00952990.2022.2073450
Source: The American Journal of Drug and Alcohol Abuse - July 26, 2022 Category: Addiction Authors: Liu Liu Juan Li Chan Wang Yue Xu Chi-Kwan Leung Genmeng Yang Shucheng Lin Shuwei Zhang Yi Tan Huijie Zhang Haowei Wang Jianxing Liu Ming Li Xiaofeng Zeng Source Type: research

Gene knockdown of HCN2 ion channels in the ventral tegmental area reduces ethanol consumption in alcohol preferring rats
CONCLUSION: These results show that knockdown of HCN2 ionic channels in the VTA of UChB rats markedly reduces their voluntary ethanol intake, supporting the idea that HCN2 channels may constitute a therapeutic target for alcohol use disorders.PMID:35377277 | DOI:10.1080/00952990.2022.2033759
Source: The American Journal of Drug and Alcohol Abuse - April 4, 2022 Category: Addiction Authors: Catalina Salinas-Luypaert Felipe S áez-Cortez Mar ía Elena Quintanilla Mario Herrera-Marschitz Mario Rivera-Meza Source Type: research

KCNK13 potassium channels in the ventral tegmental area of rats are important for excitation of VTA neurons by ethanol
CONCLUSIONS: KCNK13 plays an important role in ethanol stimulation of rat VTA neurons, and KCNK13 is dynamically regulated by cell damage, by ethanol exposure, and during withdrawal. KCNK13 is a novel alcohol-sensitive protein and further investigation of this channel may offer new avenues for the development of agents useful in altering the rewarding effect of alcohol.PMID:33960499 | DOI:10.1111/acer.14630
Source: Alcoholism, Clinical and Experimental Research - May 7, 2021 Category: Addiction Authors: Chang You Bertha J Vandegrift Mark S Brodie Source Type: research

Specifically-sized hyaluronan (35 kDa) prevents ethanol-induced disruption of epithelial tight junctions through a Layilin-dependent mechanism in Caco-2 cells.
CONCLUSION: Taken together, these data indicate that HA35 interacts with Layilin on intestinal epithelial cells and maintains intestinal tight junction integrity during short-term ethanol exposure. This article is protected by copyright. All rights reserved. PMID: 31237689 [PubMed - as supplied by publisher]
Source: Alcoholism, Clinical and Experimental Research - June 24, 2019 Category: Addiction Authors: Bellos DA, Sharma D, McMullen MR, Wat J, Saikia P, de la Motte CA, Nagy LE Tags: Alcohol Clin Exp Res Source Type: research

p53-Mediated activities in NS-5 neural stem cells: effects of ethanol.
CONCLUSIONS: Thus, it appears that ethanol and TGFβ1 affect proliferation, DNA repair, and survival of NSCs via p53-mediated activities. This article is protected by copyright. All rights reserved. PMID: 30748015 [PubMed - as supplied by publisher]
Source: Alcoholism, Clinical and Experimental Research - February 12, 2019 Category: Addiction Authors: Miller MW Tags: Alcohol Clin Exp Res Source Type: research

CREB Protein Mediates Alcohol ‐Induced Circadian Disruption and Intestinal Permeability
ConclusionsTaken together, these data suggest that strategies to reduce alcohol‐induced oxidative stress may alleviate alcohol‐mediated circadian disruption and intestinal leakiness, critical drivers of ALD. CREB Mediates Alcohol‐Induced Circadian Disruption and Intestinal Permeability (A) CLOCK and BMAL1 initiate the transcription of circadian clock genes like PER2. PER2 forms a heterodimer with CRY1 inhibiting clock gene expression. This process takes approximately 24 h. (B) We hypothesize that Cyp2e1‐mediated alcohol metabolism activates cAMP response element‐binding (CREB) protein to induce circadian gene e...
Source: Alcoholism: Clinical and Experimental Research - October 30, 2017 Category: Addiction Authors: Booker T Davis, Robin M. Voigt, Maliha Shaikh, Christopher B. Forsyth, Ali Keshavarzian Tags: Original Article Source Type: research

CREB Mediates Alcohol-Induced Circadian Disruption and Intestinal Permeability.
CONCLUSIONS: Taken together, these data suggest that strategies to reduce alcohol-induced oxidative stress may alleviate alcohol mediated circadian disruption and intestinal leakiness, critical drivers of ALD. This article is protected by copyright. All rights reserved. PMID: 28960346 [PubMed - as supplied by publisher]
Source: Alcoholism, Clinical and Experimental Research - September 27, 2017 Category: Addiction Authors: Davis BT, Voigt RM, Shaikh M, Forsyth CB, Keshavarzian A Tags: Alcohol Clin Exp Res Source Type: research

MiR ‐21‐mediated suppression of Smad7 induces TGFβ1 and can be inhibited by activation of Nrf2 in alcohol‐treated lung fibroblasts
ConclusionsAlcohol treatment increases TGFβ1 in fibroblasts, at least in part, through augmentation of miR‐21, which then inhibits Smad7 expression. These effects can be attenuated by activation of Nrf2 with SFP.This article is protected by copyright. All rights reserved.
Source: Alcoholism: Clinical and Experimental Research - September 9, 2017 Category: Addiction Authors: Lucian T. Marts, David E. Green, Stephen T. Mills, Tamara Murphy, Viranuj Sueblinvong Tags: Original Research Article Source Type: research

MiR-21-mediated suppression of Smad7 induces TGF β1 and can be inhibited by activation of Nrf2 in alcohol-treated lung fibroblasts.
CONCLUSIONS: Alcohol treatment increases TGFβ1 in fibroblasts, at least in part, through augmentation of miR-21, which then inhibits Smad7 expression. These effects can be attenuated by activation of Nrf2 with SFP. This article is protected by copyright. All rights reserved. PMID: 28888052 [PubMed - as supplied by publisher]
Source: Alcoholism, Clinical and Experimental Research - September 9, 2017 Category: Addiction Authors: Marts LT, Green DE, Mills ST, Murphy T, Sueblinvong V Tags: Alcohol Clin Exp Res Source Type: research

CREB Mediates Alcohol ‐Induced Circadian Disruption and Intestinal Permeability
ConclusionsTaken together, these data suggest that strategies to reduce alcohol‐induced oxidative stress may alleviate alcohol mediated circadian disruption and intestinal leakiness, critical drivers of ALD.This article is protected by copyright. All rights reserved.
Source: Alcoholism: Clinical and Experimental Research - September 1, 2017 Category: Addiction Authors: Booker T Davis, Robin M. Voigt, Maliha Shaikh, Christopher B. Forsyth, Ali Keshavarzian Tags: Original Research Article Source Type: research

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