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MUC1 stimulates EGFR expression and function in endometrial cancer.
Authors: Engel BJ, Bowser JL, Broaddus RR, Carson DD Abstract The current standard of care for endometrial cancer patients involves hysterectomy with adjuvant radiation and chemotherapy, with no effective treatment for advanced and metastatic disease. MUC1 is a large, heavily glycosylated transmembrane protein that lubricates and protects cell surfaces and increases cellular signaling through the epidermal growth factor receptor (EGFR). We show for the first time that MUC1 stimulates EGFR expression and function in endometrial cancer. siRNA knockdown and CRISPR/Cas knockout of MUC1 reduced EGFR gene expression, mRN...
Source: Oncotarget - April 21, 2016 Category: Cancer & Oncology Tags: Oncotarget Source Type: research