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Alanine-Serine-Cysteine Transporter 2 Inhibition Suppresses Prostate Cancer Cell Growth In Vitro
J Clin Med. 2022 Sep 16;11(18):5466. doi: 10.3390/jcm11185466.ABSTRACTAlanine-serine-cysteine transporter 2 (ASCT2) has been associated with increased levels of metabolism in various malignant tumors. However, its biological significance in the proliferation of prostate cancer (PCa) cells remains under investigation. We used the cBioPortal database to assess the effect of ASCT2 expression on the oncological outcomes of 108 PCa patients. To evaluate the function of ASCT2 in castration-sensitive PCa (CSPC) and castration-resistant PCa (CRPC), LNCaP cells and the ARV7-positive PCa cell line, 22Rv1, were assessed using cell pr...
Source: Clinical Prostate Cancer - September 23, 2022 Category: Cancer & Oncology Authors: Masanobu Saruta Kiyoshi Takahara Atsuhiko Yoshizawa Atsuko Niimi Toshiyuki Takeuchi Takuhisa Nukaya Masashi Takenaka Kenji Zennami Manabu Ichino Hitomi Sasaki Mamoru Kusaka Motoshi Suzuki Makoto Sumitomo Ryoichi Shiroki Source Type: research

Cancers, Vol. 13, Pages 5209: ARRDC4 and UBXN1: Novel Target Genes Correlated with Prostate Cancer Gleason Score
Byun To investigate potential markers of the prostate cancer (PCa) Gleason score (GS), genetic arrays in 841 PCa patients were conducted followed by functional validation in PCa cell lines. A total of 841 PCa patients who received radical prostatectomy (RP) from November 2003 to July 2019 were enrolled. HumanExome BeadChip 12v1-1 (Illumina, Inc.; San Diego, CA, USA) exomic arrays were performed on RP tissue samples. Unconditional logistic regression was used to calculate odds ratios to generate estimates of the relative risk of pathologic GS (≥8); SNPs with the highest association were selected and validated using P...
Source: Cancers - October 17, 2021 Category: Cancer & Oncology Authors: Jong Jin Oh Jin-Nyoung Ho Seok-Soo Byun Tags: Article Source Type: research

RPS7 promotes cell migration through targeting epithelial-mesenchymal transition in prostate cancer.
CONCLUSIONS: RPS7 is a newly verified tumor promoter in PCa, and promotes cell migration by targeting epithelial-to-mesenchymal transition pathway. Thus, inhibition of RPS7-epithelial to-mesenchymal transition signaling might represent a prospective approach toward limiting prostate tumor progression. PMID: 30737160 [PubMed - as supplied by publisher]
Source: Urologic Oncology - February 5, 2019 Category: Urology & Nephrology Authors: Wen Y, An Z, Qiao B, Zhang C, Zhang Z Tags: Urol Oncol Source Type: research