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Nanoparticle delivery of RNA ‐based therapeutics to alter the vocal fold tissue response to injury
ConclusionsThe current study is the first to demonstrate targeted gene manipulation in the VFs as well as the potential utility of lipitoid for localized delivery of genetic material in vivo. Ideally, these data will serve as a platform for future investigation regarding the functional implications of therapeutic gene manipulation in the VFs. Level of EvidenceNA Laryngoscope, 2017
Source: The Laryngoscope - December 14, 2017 Category: ENT & OMF Authors: Nao Hiwatashi, Iv Kraja, Peter A. Benedict, Gregory R. Dion, Renjie Bing, Bernard Rousseau, Milan R. Amin, Danielle M. Nalband, Kent Kirshenbaum, Ryan C. Branski Tags: Laryngology Source Type: research

SMAD3 expression and regulation of fibroplasia in vocal fold injury
ConclusionCumulatively, these data support SMAD3 as a potential master regulator of TGF‐β‐mediated fibrosis. SMAD3 transcription peaked 7 days following injury. Multi‐gene analysis indicated that the therapeutic effectiveness of SMAD3 knockdown may be related to regulation of downstream mediators of fibroplasia and altered TGF‐β signaling. Level of EvidenceNA. Laryngoscope, 2017
Source: The Laryngoscope - May 21, 2017 Category: ENT & OMF Authors: Nao Hiwatashi, Peter A. Benedict, Gregory R. Dion, Renjie Bing, Iv Kraja, Milan R. Amin, Ryan C. Branski Tags: Laryngology Source Type: research

Preliminary study of a novel transfection modality for in vivo siRNA delivery to vocal fold fibroblasts
ConclusionLipitoid effectively knocked down Smad3 expression across multiple transfection conditions. These preliminary data are encouraging, and lipitoid warrants further investigation with the goal of clinical utility. Level of EvidenceNA. Laryngoscope, 2016
Source: The Laryngoscope - November 30, 2016 Category: ENT & OMF Authors: Iv Kraja, Renjie Bing, Nao Hiwatashi, Bernard Rousseau, Danielle Nalband, Kent Kirshenbaum, Ryan C. Branski Tags: Laryngology Source Type: research

The role of Smad3 in the fibrotic phenotype in human vocal fold fibroblasts
ConclusionTransforming growth factor‐β1 stimulated profibrotic cell activities in our cell line and these actions were largely reduced with Smad3 knockdown. These data provide continued support for therapeutic targeting of Smad3 for vocal fold fibrosis because it appears to regulate the fibrotic phenotype. Level of EvidenceN/A. Laryngoscope, 2015
Source: The Laryngoscope - September 30, 2015 Category: ENT & OMF Authors: Ryan C. Branski, Renjie Bing, Iv Kraja, Milan R. Amin Tags: Laryngology Source Type: research

Enhanced expression of SAM‐pointed domain–containing Ets‐like factor in Chronic rhinosinusitis with nasal polyps
ConclusionsOur findings suggested that SPDEF may be regarded as a promising therapeutic target for modulating mucus hypersecretion in CRSwNP. Level of EvidenceN/A. Laryngoscope, 2014
Source: The Laryngoscope - November 6, 2014 Category: ENT & OMF Authors: Jing Bai, Beiping Miao, Xingmei Wu, Xi Luo, Renqiang Ma, Jia Zhang, Lei Li, Jianbo Shi, Huabin Li Tags: Allergy/Rhinology Source Type: research

Smad3: An emerging target for vocal fold fibrosis
Conclusion. These data provide a foundation for further investigation regarding the development of novel RNA‐based therapeutics for the VF, specifically locally‐delivered siRNA for challenging fibrotic conditions of the VF.
Source: The Laryngoscope - April 16, 2014 Category: ENT & OMF Authors: Benjamin C. Paul, Benjamin Y. Rafii, Sonate Gandonu, Renjie Bing, Hayley Born, Milan R. Amin, Ryan C. Branski Tags: Original Report Source Type: research