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In silico, in vitro and in vivo analysis identifies endometrial circadian clock genes in recurrent implantation failure
CONCLUSION: Aberrant expression of endometrial PER2 might contribute to impaired endometrial receptivity and development of RIF via regulating SHTN1, KLF5, and STEAP4.PMID:33619544 | DOI:10.1210/clinem/dgab119
Source: The Journal of Clinical Endocrinology and Metabolism - February 23, 2021 Category: Endocrinology Authors: Junyu Zhai Shang Li Jingwen Hu Minzhi Gao Yun Sun Zi-Jiang Chen Linda C Giudice Yanzhi Du Source Type: research

Characterization of GAB1 expression over the menstrual cycle in women with and without Polycystic Ovarian Syndrome provides a new insight into its pathophysiology.
Conclusions: GAB1 mRNA expression is positively modulated by E2. Endometrial GAB1 protein and mRNA expression are reduced in women with PCOS, suggesting that the endometrium of PCOS women have a defect in insulin signaling due to GAB1 down-regulation. PMID: 25144631 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - August 21, 2014 Category: Endocrinology Authors: Roemer KL, Young SL, Savaris RF Tags: J Clin Endocrinol Metab Source Type: research