• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Late Breaking Abstract - Aldo-keto reductases expression correlate corticoids efficacy in vitro and on chronic rhinosinusitis with nasal polyps
Conclusion: AKR1C1, and possibly AKR1C2, seem to participate in the corticoid response by a non-catalytic mechanism, which may be related to GRα nuclear localization. Based on in vitro evidence, the high expression of AKR1C1 in CRSwNP patients may relate to corticoid resistance.
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Morell, A., Milara, J., Lastovickova, L., Roger, I., Garcia-Lliberos, A., Zapater-Latorre, E., Armengot, M., Cortijo, J., Wsol, V. Tags: Airway pharmacology and treatment Source Type: research

Oligonucleotides —A Novel Promising Therapeutic Option for IBD
Conclusions In this review, we focused on recent and past approaches to test the therapeutic efficacy of oligonucleotide based therapies in IBD. The combining mechanistic mode of oligonucleotide based therapeutics is a targeted action on specific pro-inflammatory molecules, which are over activated in IBD patients and contribute significantly to disease pathogenesis. The proposed high selectivity of the agents is derived from its mode of action, that aims to specifically block certain inflammatory molecular patterns, without a general systemic effect on other molecular targets. It would be important for each oligonucleot...
Source: Frontiers in Pharmacology - April 23, 2019 Category: Drugs & Pharmacology Source Type: research

Prevention of esophageal stricture after endoscopic submucosal dissection using RNA-based silencing of carbohydrate sulfotransferase 15 in a porcine model
Conclusion CHST15 siRNA alleviated esophageal post-ESD stricture formation via repression of fibrosis, revealing a novel therapeutic role for antifibrotic agents in the prevention of post-ESD strictures. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Endoscopy - March 5, 2017 Category: Gastroenterology Authors: Sato, Hiroki Sagara, Seiji Nakajima, Nao Akimoto, Teppei Suzuki, Kenji Yoneyama, Hiroyuki Terai, Shuji Yahagi, Naohisa Tags: Innovations and brief communication Source Type: research

MUC4 overexpression correlates corticoid resistance in chronic rhinosinusitis with nasal polyps
Conclusion: MUC4 participates in the corticoid response that mediates GRα nuclear translocation. The high expression of MUC4 in patients with CRSwNP may participate in corticoid resistance.
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Contreras, S., Serrano, A., Diaz, L., Ballester, B., Banuls, P., Milara, J., Morell, A. Tags: 5.1 Airway Pharmacology and Treatment Source Type: research