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Epigenetic Metabolic Reprogramming of Right Ventricular Fibroblasts in Pulmonary Arterial Hypertension: A Pyruvate Dehydrogenase Kinase-Dependent Shift in Mitochondrial Metabolism Promotes Right Ventricular Fibrosis.
Conclusions: MCT-RVfib manifest a DNMT1-HIF-1α-PDK-mediated, chamber-specific, metabolic memory that promotes collagen production and RV fibrosis. This epigenetic mitochondrial-metabolic pathway is a potential antifibrotic therapeutic target. PMID: 32216531 [PubMed - as supplied by publisher]
Source: Circulation Research - March 26, 2020 Category: Cardiology Authors: Tian L, Wu D, Dasgupta A, Chen KH, Mewburn J, Potus F, Lima PA, Hong Z, Zhao YY, Hindmarch C, Kutty S, Provencher S, Bonnet S, Sutendra G, Archer SL Tags: Circ Res Source Type: research

Uric Acid Induces Cardiomyocyte Apoptosis via Activation of Calpain-1 and Endoplasmic Reticulum Stress
Conclusions: These findings suggest that UA induces cardiomyocyte apoptosis through activation of calpain-1 and ER stress. These results may provide new insights into the mechanisms of hyperuricemia-associated cardiovascular risks and hopefully identify new treatment targets.Cell Physiol Biochem 2018;45:2122 –2135
Source: Cellular Physiology and Biochemistry - March 13, 2018 Category: Cytology Source Type: research