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Tangshen Formula Alleviates Hepatic Steatosis by Inducing Autophagy Through the AMPK/SIRT1 Pathway
Conclusion In conclusion, the present study demonstrated that autophagy was involved in relieving the effects of TSF against NAFLD, which were mediated by the AMPK/SIRT1 pathway (Figure 7D). These findings may improve our current understanding of the role of TSF in treating hepatic steatosis and provide an experimental basis for the clinical application of TSF in NAFLD and its related metabolic syndrome. Ethics Statement This study was carried out in accordance with the recommendations in the Guide for the Care and Use of Laboratory Animals of the National Institutes of Health. The protocol was approved by the Ethics Co...
Source: Frontiers in Physiology - April 25, 2019 Category: Physiology Source Type: research

Rhein protects the myocardiac cells against hypoxia/reoxygention-induced injury by suppressing GSK3β activity
ConclusionRhein protects myocardial H9c2 cells against hypoxia/reoxygenation induced injury via AKT/ GSK3β/p38 pathway.Graphical abstract
Source: Phytomedicine - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Rhein protects the myocardiac cells against hypoxia/reoxygention-induced injury by suppressing GSK3 β activity
Conclusion Rhein protects myocardial H9c2 cells against hypoxia/reoxygenation induced injury via AKT/ GSK3β/p38 pathway. Graphical abstract
Source: Phytomedicine - June 22, 2018 Category: Drugs & Pharmacology Source Type: research