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Organic Cation Transporter I and Na+/taurocholate Co ?Transporting Polypeptide are Involved in Retrorsine? and Senecionine?Induced Hepatotoxicity in HepaRG cells
ConclusionOur results confirm previous findings of active transport mechanisms of PAs into hepatocytes and highlight the importance of toxicokinetic studies for the risk assessment of PAs.
Source: Molecular Nutrition and Food Research - December 11, 2021 Category: Food Science Authors: Anne ?Margarethe Enge, Florian Kaltner, Christoph Gottschalk, Angelina Kin, Michael Kirstgen, Joachim Geyer, Anja These, Helen Hammer, Oliver P�tz, Albert Braeuning, Stefanie Hessel?Pras Tags: Research Article Source Type: research

Mblk ‐1 regulates sugar responsiveness in honey bee (Apis mellifera) foragers
This article is protected by copyright. All rights reserved
Source: Insect Science - September 28, 2021 Category: Biology Authors: Fang Liu, Lixian Wu, Yuan Zhang, Qiang Li, Liangbin Li, Zachary Y. Huang, Hongxia Zhao Tags: ORIGINAL ARTICLE Source Type: research

Effective Targeting of Raf-1 and Its Associated Autophagy by Novel Extracted Peptide for Treating Breast Cancer Cells
Breast cancer is one of the most common causes of death in women worldwide and has harmful influence on their psychological state during therapy. Multikinase inhibitors have become effective drugs for treating a variety of cancer diseases such as breast cancer. A purified short peptide (H-P) was isolated from the natural honey and tested for its potential regulatory role in breast cancer cells compared with the effectiveness of the anticancer drug, Sorafenib (SOR), using MCF-7, EFM-19, and MCF-10A cell lines. Furthermore, we investigated the direct connection between Raf-1 activation and cellular autophagy as potential tar...
Source: Frontiers in Oncology - August 27, 2021 Category: Cancer & Oncology Source Type: research

Targeting the honey bee gut parasite Nosema ceranae with siRNA positively affects gut bacteria
Gut microbial communities can contribute positively and negatively to host health. So far, eight core bacterial taxonomic clusters have been reported in honey bees. These bacteria are involved in host metaboli...
Source: BMC Microbiology - August 17, 2020 Category: Microbiology Authors: Qiang Huang and Jay D. Evans Tags: Research article Source Type: research

Bee’s honey attenuates non-alcoholic steatohepatitis-induced hepatic injury through the regulation of thioredoxin-interacting protein–NLRP3 inflammasome pathway
Conclusion Suppression of the TXNIP–NLRP3 inflammasome pathway may partly contribute to the amelioration of hepatic injury during the progression of NASH by honey. Targeting hepatic TXNIP–NLRP3 inflammasome pathway is a potential therapeutic way for the prevention and treatment of NASH.
Source: European Journal of Nutrition - July 2, 2015 Category: Nutrition Source Type: research

Characterization of viral siRNA populations in honey bee colony collapse disorder.
Abstract Colony Collapse Disorder (CCD), a special case of collapse of honey bee colonies, has resulted in significant losses for beekeepers. CCD-colonies show abundance of pathogens which suggests that they have a weakened immune system. Since honey bee viruses are major players in colony collapse and given the important role of viral RNA interference (RNAi) in combating viral infections we investigated if CCD-colonies elicit an RNAi response. Deep-sequencing analysis of samples from CCD-colonies from US and Israel revealed abundant small interfering RNAs (siRNA) of 21-22 nucleotides perfectly matching the Israel...
Source: Virology - April 1, 2014 Category: Virology Authors: Chejanovsky N, Ophir R, Schwager MS, Slabezki Y, Grossman S, Cox-Foster D Tags: Virology Source Type: research