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Sialylation by β‑galactoside α‑2,6‑sialyltransferase and N‑glycans regulate cell adhesion and invasion in human anaplastic large cell lymphoma.
Abstract The interaction between cell surface glycans and extracellular matrix (ECM) including galectins is known to be closely associated with tumor cell adhesion, invasion and metastasis. We analyzed the roles of cell surface sialylation or glycosylation in galectin or ECM‑mediated cell adhesion and invasion of human malignant lymphoma cells. Neuraminidase from Arthrobacter ureafaciens (AU) treatment resulted in reduction of cell adhesion to galectin‑8 in human anaplastic large cell lymphoma (H‑ALCL) which was established in our laboratory. The knockdown of β‑galactoside α‑2,6‑sialyltrans-ferase...
Source: International Journal of Oncology - January 7, 2015 Category: Cancer & Oncology Authors: Suzuki O, Abe M, Hashimoto Y Tags: Int J Oncol Source Type: research