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Lycium barbarum Polysaccharides Promote Maturity of Murine Dendritic Cells through Toll-Like Receptor 4-Erk1/2-Blimp1 Signaling Pathway.
In conclusion, our results indicate that LBP can induce maturation of DCs through the TLR4-Erk1/2-Blimp1 signal pathway instead of the JNK/p38-Blimp1 pathway. Our findings may provide a novel evidence for understanding the molecular mechanisms of LBP on activating murine DCs. PMID: 33344654 [PubMed - in process]
Source: Journal of Immunology Research - December 23, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Lycium barbarum polysaccharide reduces hyperoxic acute lung injury in mice through Nrf2 pathway
ConclusionsLBP improves hyperoxic ALI via Nrf2-dependent manner. The LBP-induced activation of Nrf2 is mediated, at least in part, by AMPK pathway.
Source: Biomedicine and Pharmacotherapy - January 4, 2019 Category: Drugs & Pharmacology Source Type: research

Lycium barbarum polysaccharide reduces hyperoxic acute lung injury in mice through Nrf2 pathway.
CONCLUSIONS: LBP improves hyperoxic ALI via Nrf2-dependent manner. The LBP-induced activation of Nrf2 is mediated, at least in part, by AMPK pathway. PMID: 30611998 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - January 3, 2019 Category: Drugs & Pharmacology Authors: Zheng G, Ren H, Li H, Li X, Dong T, Xu S, Yan Y, Sun B, Bai J, Li Y Tags: Biomed Pharmacother Source Type: research

Lycium barbarum polysaccharide protects human keratinocytes against UVB-induced photo-damage.
Authors: Li H, Li Z, Peng L, Jiang N, Liu Q, Zhang E, Liang B, Li R, Zhu H Abstract Ultraviolet B (UVB) irradiation plays a key role in skin damage, which induces oxidative and inflammatory damages, thereby causing photoaging or photocarcinogenesis. Lycium barbarum polysaccharide (LBP), the most biologically active fraction of wolfberry, possesses significant antioxidative and anti-inflammatory effects on multiple tissues. In the present study, the photoprotective effects and potential underlying molecular mechanisms of LBP against UVB-induced photo-damage were investigated in immortalized human keratinocytes (HaCa...
Source: Free Radical Research - March 15, 2017 Category: Research Tags: Free Radic Res Source Type: research

Lycium barbarum polysaccharide attenuates alcoholic cellular injury through TXNIP-NLRP3 inflammasome pathway.
In conclusion, inhibition of hepatic TXNIP by LBP contributes to the reduction of cellular apoptosis, oxidative stress and NLRP3 inflammasome-mediated inflammation. PMID: 24858535 [PubMed - as supplied by publisher]
Source: International Journal of Biological Macromolecules - May 22, 2014 Category: Biochemistry Authors: Xiao J, Zhu Y, Liu Y, Tipoe GL, Xing F, So KF Tags: Int J Biol Macromol Source Type: research