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Cancers, Vol. 11, Pages 701: Transglutaminase-2 Mediates the Biomechanical Properties of the Colorectal Cancer Tissue Microenvironment that Contribute to Disease Progression
In conclusion, this study demonstrates a role for TG2 in the stromal response to invading tumour, leading to tissue stiffening and poor outcome in patients.
Source: Cancers - May 20, 2019 Category: Cancer & Oncology Authors: Robin Delaine-Smith Nicola Wright Chris Hanley Rebecca Hanwell Rahul Bhome Marc Bullock Cole Drifka Kevin Eliceiri Gareth Thomas Martin Knight Alex Mirnezami Nicholas Peake Tags: Article Source Type: research
PKC ε Increases Extracellular Elastin and Fibulin-5/DANCE in Dermal Fibroblasts
Conclusion: The results of the present study indicate that PKC ε, activated by DCP-LA, increases elastin and fibulin-5/DANCE in the extracellular space of cultured fibroblasts by the mechanism independent of transcriptional and translational modulation or inhibition of elastolysis.Cell Physiol Biochem 2018;46:291 –302
Source: Cellular Physiology and Biochemistry - March 28, 2018 Category: Cytology Source Type: research
