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UCP2 attenuates apoptosis of tubular epithelial cells in renal ischemia-reperfusion injury
Uncoupling protein-2 (UCP2) plays critical roles in energy metabolism and cell survival. Previous investigations showed that UCP2 regulated the production of extracellular matrix and renal fibrosis. However, little is known about UCP2 in acute kidney injury (AKI). Here, we used Ucp2 knockout mice to investigate the role of UCP2 in an AKI model generated by renal ischemia-reperfusion (I/R) injury. The Ucp2 global knockout mice were born and grew normally without kidney histological abnormality or renal dysfunction. Compared with littermates, deletion of Ucp2 exacerbated I/R-induced AKI whereas increase of UCP2 by conjugated...
Source: AJP: Renal Physiology - October 1, 2017 Category: Urology & Nephrology Authors: Zhou, Y., Cai, T., Xu, J., Jiang, L., Wu, J., Sun, Q., Zen, K., Yang, J. Tags: RESEARCH ARTICLE Source Type: research

UCP2 attenuates apoptosis of tubular epithelial cells in renal ischemia/reperfusion injury.
Abstract Uncoupling protein 2 (UCP2) plays critical roles in energy metabolism and cell survival. Previous investigations showed that UCP2 regulated the production of extracellular matrix and renal fibrosis. However, little is known about UCP2 in acute kidney injury. Here, we used UCP2 knockout mice to investigate the role of UCP2 in AKI model generated by renal ischemia/reperfusion (I/R) injury. The UCP2 global knockout mice were born and growth normal without kidney histological abnormality or renal dysfunctions. As compared with littermates, deletion of UCP2 exacerbated I/R-induced AKI while increase of UCP2 by...
Source: American Journal of Physiology. Renal Physiology - April 19, 2017 Category: Physiology Authors: Zhou Y, Cai T, Xu J, Jiang L, Wu J, Sun Q, Zen K, Yang J Tags: Am J Physiol Renal Physiol Source Type: research

Proteomic Analysis Reveals PGAM1 Altering cis -9 , trans -11 Conjugated Linoleic Acid Synthesis in Bovine Mammary Gland
In conclusion, our data suggested that PGAM1 may have a negative relationship with SCD1 and seemed to be involved in cis-9, trans-11 CLA synthesis by facilitating the absorption of trans-11 C18:1 in the bovine mammary gland.
Source: Lipids - March 29, 2015 Category: Lipidology Source Type: research

Diacylglycerol kinase inhibitor R59022 attenuates conjugated linoleic acid-mediated inflammation in human adipocytes Research Articles
Diacylglycerol kinases (DGK) convert diacylglycerol to phosphatidic acid, which has been reported to stimulate calcium release from the endoplasmic reticulum. Based on our published data showing that trans-10, cis-12 conjugated linoleic acid (t10,c12 CLA)-mediated intracellular calcium accumulation is linked to inflammation and insulin resistance, we hypothesized that inhibiting DGKs with R59022 would prevent t10,c12 CLA-mediated inflammatory signaling and insulin resistance in human adipocytes. Consistent with our hypothesis, R59022 attenuated t10,c12 CLA-mediated i) increased gene expression and protein secretion of inte...
Source: The Journal of Lipid Research - February 12, 2013 Category: Lipidology Authors: Martinez, K., Shyamasundar, S., Kennedy, A., Chuang, C. C., Marsh, A., Kincaid, J., Reid, T., McIntosh, M. Tags: Research Articles Source Type: research