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Autophagy Activation in Brain Endothelium by GBS Cell Biology
Bacterial meningitis occurs when bloodborne pathogens invade and penetrate the blood-brain barrier (BBB), provoking inflammation and disease. Group B Streptococcus (GBS), the leading cause of neonatal meningitis, can enter human brain microvascular endothelial cells (hBMECs), but the host response to intracellular GBS has not been characterized. Here we sought to determine whether antibacterial autophagy, which involves selective recognition of intracellular organisms and their targeting to autophagosomes for degradation, is activated in BBB endothelium during bacterial infection. GBS infection resulted in increased puncta...
Source: Journal of Biological Chemistry - December 26, 2014 Category: Chemistry Authors: Cutting, A. S., Del Rosario, Y., Mu, R., Rodriguez, A., Till, A., Subramani, S., Gottlieb, R. A., Doran, K. S. Tags: Molecular Bases of Disease Source Type: research