Filtered By:
Infectious Disease: Meningitis

This page shows you your search results in order of date.

Order by Relevance | Date

Total 16 results found since Jan 2013.

AMPK protects endothelial cells against HSV-1 replication via inhibition of mTORC1 and ACC1
Microbiol Spectr. 2023 Sep 13:e0041723. doi: 10.1128/spectrum.00417-23. Online ahead of print.ABSTRACTHerpes simplex virus type 1 (HSV-1) is a widespread contagious pathogen, mostly causing mild symptoms on the mucosal entry side. However, systemic distribution, in particular upon reactivation of the virus in immunocompromised patients, may trigger an innate immune response and induce damage of organs. In these conditions, HSV-1 may infect vascular endothelial cells, but little is known about the regulation of HSV-1 replication and possible defense mechanisms in these cells. The current study addresses the question of whet...
Source: Herpes - September 13, 2023 Category: Infectious Diseases Authors: Heena Doshi Katrin Spengler Amod Godbole Yi Sing Gee Jonathan Baell Jonathan S Oakhill Andreas Henke Regine Heller Source Type: research

Synergistic regulation of microglia differentiation by CD93 and integrin β1 in the rat pneumococcal meningitis model
In conclusion, interaction between integrin β1 and CD93 promotes differentiation of microglia to the M1 phenotype, increases the release of pro-inflammatory factors, and leads to nervous system injury in pneumococcal meningitis.PMID:36336138 | DOI:10.1016/j.imlet.2022.11.001
Source: Immunology Letters - November 6, 2022 Category: Allergy & Immunology Authors: Nana Qiao Jinghui Zhang Ya Zhang Xinjie Liu Source Type: research

Poldip2 mediates blood-brain barrier disruption and cerebral edema by inducing AQP4 polarity loss in mouse bacterial meningitis model.
CONCLUSION: Poldip2 inhibition alleviated brain edema and preserved the integrity of BBB partially by relieving the loss of AQP4 polarity via MMPs/β-DG pathway. PMID: 32790044 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - August 11, 2020 Category: Neuroscience Authors: Gao M, Lu W, Shu Y, Yang Z, Sun S, Xu J, Gan S, Zhu S, Qiu G, Zhuo F, Xu S, Wang Y, Chen J, Wu X, Huang J Tags: CNS Neurosci Ther Source Type: research

HIF-1 α is involved in blood–brain barrier dysfunction and paracellular migration of bacteria in pneumococcal meningitis
AbstractBacterial meningitis is a deadly disease most commonly caused byStreptococcus pneumoniae, leading to severe neurological sequelae including cerebral edema, seizures, stroke, and mortality when untreated. Meningitis is initiated by the transfer ofS. pneumoniae from blood to the brain across the blood –cerebrospinal fluid barrier or the blood–brain barrier (BBB). The underlying mechanisms are still poorly understood. Current treatment strategies include adjuvant dexamethasone for inflammation and cerebral edema, followed by antibiotics. The success of dexamethasone is however inconclusive, ne cessitating new ther...
Source: Acta Neuropathologica - June 10, 2020 Category: Neurology Source Type: research

Autophagy Is a Defense Mechanism Inhibiting Invasion and Inflammation During High-Virulent Haemophilus parasuis Infection in PK-15 Cells
In this study, we sought to investigate whether SH0165 (serovar 5, high-virulent strain) and HN0001 (serovar 6, non-virulent strain) infection induces autophagy and the specific role of autophagy in bacterial invasion and inflammation during H. parasuis infection. Moreover, we explored the mechanism underlying autophagy regulated inflammation through inflammatory signaling cascades during H. parasuis infection. This observation could provide useful information for further understanding the role of autophagy in H. parasuis infection and improve our knowledge of new strategies against this pathogen. Materials and Methods B...
Source: Frontiers in cellular and infection microbiology - April 15, 2019 Category: Microbiology Source Type: research

Heat shock protein 70 as a supplementary receptor facilitates enterovirus 71 infections in vitro
In this study, siRNA interference technique and transgenic technique were used to investigate the interaction between HSP70 and EV71 virus. The result demonstrated that the cell surface HSP70 is not essential for EV71 infection but helps the initial binding of virus to host cells and that multiple receptors are involved during EV71 infection. In addition, HSP70 was upregulated in human neuroblastoma cells (SK-N-SH) infected with EV71.Graphical abstractEnterovirus 71 (EV71) is a causative agent of hand food and mouth disease (HFMD) in young children and it can cause the damage of nervous cells, cytokine storm and toxic subs...
Source: Microbial Pathogenesis - December 30, 2018 Category: Infectious Diseases Source Type: research

Heat shock protein 70 as a supplementary receptor facilitates enterovirus 71infections in vitro
In this study, siRNA interference technique and transgenic technique were used to investigate the interaction between HSP70 and EV71 virus. The result demonstrated that the cell surface HSP70 is not essential for EV71 infection but helps the initial binding of virus to host cells and that multiple receptors are involved during EV71 infection. In addition, HSP70 was upregulated in human neuroblastoma cells (SK-N-SH) infected with EV71.Graphical abstractEnterovirus 71 (EV71) is a causative agent of hand food and mouth disease (HFMD) in young children and it can cause the damage of nervous cells, cytokine storm and toxic subs...
Source: Microbial Pathogenesis - December 22, 2018 Category: Infectious Diseases Source Type: research