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Epigenetic upregulation of ssc-miR-124a following treatment with Clostridium perfringens beta2-toxin attenuates both apoptosis and inflammation in intestinal porcine epithelial cells.
Abstract Clostridium perfringens (C. perfringens) is a globally recognized zoonotic pathogen. It has been reported that the beta2-toxin produced by C. perfringens can cause a variety of gastrointestinal diseases and even systemic inflammation. MicroRNA-124a (miR-124a) has been reported to play important roles in the host response to pathogenic infection. Although C. perfringens beta2-toxin induced injury in intestinal porcine epithelial (IPEC-J2) cells has been established, the underlying molecular mechanism is not completely unraveled. Here we show that a significant upregulation of ssc-miR-124a in IPEC-J2 cells ...
Source: Archives of Biochemistry and Biophysics - February 12, 2021 Category: Biochemistry Authors: Gao X, Yang Q, Zhang S, Huang X, Yan Z, Wang P, Luo R, Wang W, Xie K, Gun S Tags: Arch Biochem Biophys Source Type: research

Role of P2X7 receptor in Clostridium perfringens beta-toxin-mediated cellular injury
Conclusions The results of this study indicate that the P2X7 receptor plays a role in beta-toxin-mediated cellular injury. General Significance P2X7 receptor is a potential target for the treatment of C. perfringens type C infection.
Source: Biochimica et Biophysica Acta (BBA) General Subjects - August 20, 2015 Category: Biochemistry Source Type: research