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Infectious Disease: Chagas Disease

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Total 5 results found since Jan 2013.

Genes of the cGMP-PKG-Ca2+ signaling pathway are alternatively spliced in cardiomyopathy: Role of RBFOX2
Publication date: Available online 25 November 2019Source: Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseAuthor(s): Xianxiu Wan, KarryAnne Belanger, Steven G. Widen, Muge N. Kuyumcu-Martinez, Nisha J. GargAbstractAberrations in the cGMP-PKG-Ca2+ pathway are implicated in cardiovascular complications of diverse etiologies, though involved molecular mechanisms are not understood. We performed RNA-Seq analysis to profile global changes in gene expression and exon splicing in Chagas disease (ChD) murine myocardium. Ingenuity-Pathway-Analysis of transcriptome dataset identified 26 differentially expressed gene...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - November 26, 2019 Category: Molecular Biology Source Type: research

Clathrin coated pit dependent pathway for trypanosoma cruzi internalization into host cells.
CLATHRIN COATED PIT DEPENDENT PATHWAY FOR TRYPANOSOMA CRUZI INTERNALIZATION INTO HOST CELLS. Acta Trop. 2019 Jun 13;:105057 Authors: Barrias E, Reignault L, de Carvalho TMU, de Souza W Abstract A number of intracellular pathogens are internalized by host cells via multiple endocytic pathways, including Trypanosoma cruzi, the etiological agent of Chagas disease. Clathrin-mediated endocytosis is the most characterized endocytic pathway in mammalian cells. Its machinery was described as being required in mammalian cells for the internalization of large particles, including pathogenic bacteria, fungi, and...
Source: Acta Tropica - June 12, 2019 Category: Infectious Diseases Authors: Barrias E, Reignault L, de Carvalho TMU, de Souza W Tags: Acta Trop Source Type: research

IL-10/STAT3/SOCS3 Axis Is Involved in the Anti-inflammatory Effect of Benznidazole
Anti-parasitic treatment for Chagas disease mainly relies on benznidazole, which is virtually the only drug available in the market. Besides its anti-parasitic effects, benznidazole has anti-inflammatory properties. In this work we studied the mechanisms involved in the latter, demonstrating the participation of the IL-10/STAT3/SOCS3 pathway. To achieve this goal, the anti-inflammatory properties of benznidazole were studied using an in vitro model of cardiomyocyte primary culture stimulated with LPS. LPS increased both SOCS3 expression and STAT3 phosphorylation. The addition of benznidazole increased their expression even...
Source: Frontiers in Immunology - June 3, 2019 Category: Allergy & Immunology Source Type: research

SNARE proteins required during Trypanosoma cruzi parasitophorous vacuole development
Abstract Trypanosoma cruzi, the etiologic agent of Chagas disease, is an obligate intracellular parasite that exploits different host vesicular pathways to invade the target cells. Vesicular and target SNAREs are key proteins of the intracellular membrane fusion machinery. During the early times of T. cruzi infection, several vesicles are attracted to the parasite contact sites in the plasma membrane. Fusion of these vesicles promotes the formation of the parasitic vacuole and parasite entry. In this work, we study the requirement and the nature of SNAREs involved in the fusion events which take place during T. cruzi infec...
Source: Cellular Microbiology - November 30, 2016 Category: Microbiology Authors: Juan Agust ín Cueto, María Cristina Vanrell, Betiana Nebaí Salassa, Sébastien Nola, Thierry Galli, María Isabel Colombo, Patricia Silvia Romano Tags: RESEARCH ARTICLE Source Type: research

The involvement of FAK and Src in the invasion of cardiomyocytes by Trypanosoma cruzi.
Abstract The activation of signaling pathways involving protein tyrosine kinases (PTKs) has been demonstrated during Trypanosoma cruzi invasion. Herein, we describe the participation of FAK/Src in the invasion of cardiomyocytes by T. cruzi. The treatment of cardiomyocytes with genistein, a PTK inhibitor, significantly reduced T. cruzi invasion. Also, PP1, a potent Src-family protein inhibitor, and PF573228, a specific FAK inhibitor, also inhibited T. cruzi entry; maximal inhibition was achieved at concentrations of 25μM PP1 (53% inhibition) and 40μM PF573228 (50% inhibition). The suppression of FAK expression in...
Source: Experimental Parasitology - February 25, 2014 Category: Parasitology Authors: de Melo TG, Tucci AR, Nogueira AR, Meirelles MD, Pereira MC Tags: Exp Parasitol Source Type: research