• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

BK virus infection activates the TNFα/TNF receptor system in Polyomavirus-associated nephropathy.
Abstract Polyomavirus-associated nephropathy due to BK virus infection (BKVAN) is recognized as an important cause of significant kidney transplant dysfunction often leading to renal graft loss. The activation of innate immune defense mechanisms during BKVAN is still poorly understood and an altered regulation of inflammatory mediators by resident kidney cells upon viral infection can be expected to contribute to the onset and progression of disease. TNFα interacting with its receptors, TNF receptor 1 (TNFR1) and TNF receptor 2 (TNFR2), is largely accepted to be involved in viral responses, exhibiting both proinf...
Source: Molecular and Cellular Biochemistry - October 7, 2015 Category: Biochemistry Authors: Ribeiro A, Merkle M, Motamedi N, Nitschko H, Köppel S, Wörnle M Tags: Mol Cell Biochem Source Type: research

Host cell autophagy promotes BK virus infection.
Abstract Autophagy is important for a variety for virus life cycles. We sought to determine the role of autophagy in human BK polyomavirus (BKPyV) infection. The addition excess amino acids during viral infection reduced BKPyV infection. Perturbing autophagy levels using inhibitors, 3-MA, bafilomycin A1, and spautin-1, also reduced infection, while rapamycin treatment of host cells increased infection. siRNA knockdown of autophagy genes, ATG7 and Beclin-1, corresponded to a decrease in BKPyV infection. BKPyV infection not only correlated with autophagosome formation, but also virus particles localized to autophagy...
Source: Virology - May 1, 2014 Category: Virology Authors: Bouley SJ, Maginnis MS, Derdowski A, Gee GV, O׳Hara BA, Nelson CD, Bara AM, Atwood WJ, Dugan AS Tags: Virology Source Type: research