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Infectious Disease: H3N2
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Total 20 results found since Jan 2013.
Induction of IFN- β through both TLR-3- and RIG-I-mediated signaling pathways in canine respiratory epithelial cells infected with H3N2 canine influenza virus
In this study, we aimed to determine the signaling pathways leading to the induction of IFN-β in a canine respiratory epithelial cell line (i.e., KU-CBE) infected with the H3N2 subtype of CIV. Small interfering RNAs (siRNAs) specific to pattern recognition receptors (PRRs) and transcription factors were used to block the IFN-β-induction signals in H3N2 CIV-infected KU-CBE cells. Among the PRRs, only the TLR3 and RIG-I expression levels significantly (P < 0.001) increased in CIV-infected cells. Following transfection with siRNA specific to TLR3 (siTLR3) or RIG-I (siRIG-I), the mRNA expression levels of IFN-β significa...
Source: Journal of Microbiology and Biotechnology - June 8, 2021 Category: Biotechnology Authors: Woo-Jung Park Sang-Hoon Han Dong-Hwi Kim Young-Jo Song Joong-Bok Lee Seung-Yong Park Chang-Seon Song Sang-Won Lee In-Soo Choi Source Type: research
