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Source: International Journal of Pharmaceutics

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Total 111 results found since Jan 2013.

Innovative lipoplexes formulations with enhanced siRNA efficacy for cancer treatment: Where are we now?
Publication date: Available online 1 July 2021Source: International Journal of PharmaceuticsAuthor(s): Manon Berger, Anna Lechanteur, Brigitte Evrard, Géraldine Piel
Source: International Journal of Pharmaceutics - July 3, 2021 Category: Drugs & Pharmacology Source Type: research

Nanotechnology-based siRNA delivery strategies for treatment of triple negative breast cancer
Publication date: Available online 28 June 2021Source: International Journal of PharmaceuticsAuthor(s): Rahul Chadar, Afsana, Prashant Kesharwani
Source: International Journal of Pharmaceutics - June 29, 2021 Category: Drugs & Pharmacology Source Type: research

Cationic lipid nanoparticle production by microfluidization for siRNA delivery
Publication date: Available online 5 June 2021Source: International Journal of PharmaceuticsAuthor(s): Xiaojing Liu, Badr Bahloul, René Lai Kuen, Karine Andrieux, Caroline Roques, Daniel Scherman
Source: International Journal of Pharmaceutics - June 5, 2021 Category: Drugs & Pharmacology Source Type: research

Fabricating nanoparticles co-loaded with survivin siRNA and Pt(IV) prodrug for the treatment of platinum-resistant lung cancer
Publication date: Available online 8 April 2021Source: International Journal of PharmaceuticsAuthor(s): Shuting Ma, Xiaowen Li, Meixin Ran, Muse Ji, Jingxin Gou, Tian Yin, Haibing He, Yanjiao Wang, Yu Zhang, Xing Tang
Source: International Journal of Pharmaceutics - April 10, 2021 Category: Drugs & Pharmacology Source Type: research

Combining dexamethasone and TNF-α siRNA within the same nanoparticles to enhance anti-inflammatory effect
Publication date: Available online 19 February 2021Source: International Journal of PharmaceuticsAuthor(s): Serra Gürcan, Nicolas Tsapis, Franceline Reynaud, Stéphanie Denis, Juliette Vergnaud, Özgen Özer, Elias Fattal
Source: International Journal of Pharmaceutics - February 20, 2021 Category: Drugs & Pharmacology Source Type: research

Hybrid Micelles Codelivering Shikonin and IDO-1 siRNA Enhance Immunotherapy by Remodeling Immunosuppressive Tumor Microenvironment
Publication date: Available online 2 February 2021Source: International Journal of PharmaceuticsAuthor(s): Ji Li, Ming Zhao, Yunhua Xu, Xiaoyun Hu, Yinghui Dai, Dongkai Wang
Source: International Journal of Pharmaceutics - February 2, 2021 Category: Drugs & Pharmacology Source Type: research

PLGA/PCADK Composite Microspheres Containing Hyaluronic Acid–Chitosan siRNA Nanoparticles: A Rational Design for Rheumatoid Arthritis Therapy
Publication date: Available online 23 January 2021Source: International Journal of PharmaceuticsAuthor(s): Menghui Zhao, Tianyu Zhu, Jicong Chen, Yaxin Cui, Xueyan Zhang, Robert J. Lee, Fengying Sun, Youxin Li, Lesheng Teng
Source: International Journal of Pharmaceutics - January 25, 2021 Category: Drugs & Pharmacology Source Type: research

Aerosolizable siRNA-Encapsulated Solid Lipid Nanoparticles Prepared by Thin-film Freeze-Drying for Potential Pulmonary Delivery
Publication date: Available online 21 January 2021Source: International Journal of PharmaceuticsAuthor(s): Jie-Liang Wang, Mahmoud S. Hanafy, Haiyue Xu, Jasmim Leal, Yufeng Zhai, Debadyuti Ghosh, Robert O. Williams III, Hugh David Charles Smyth, Zhengrong Cui
Source: International Journal of Pharmaceutics - January 22, 2021 Category: Drugs & Pharmacology Source Type: research

Aptamer-Protamine-siRNA nanoparticles in targeted therapy of ErbB3 positive breast cancer cells
Publication date: Available online 9 October 2020Source: International Journal of PharmaceuticsAuthor(s): Xiangshang Xu, Li Li, Xiaolan Li, Deding Tao, Peng Zhang, Jianping Gong
Source: International Journal of Pharmaceutics - October 9, 2020 Category: Drugs & Pharmacology Source Type: research

Hypoxia-sensitive micellar nanoparticles for co-delivery of siRNA and chemotherapeutics to overcome multi-drug resistance in tumor cells
Publication date: Available online 24 September 2020Source: International Journal of PharmaceuticsAuthor(s): Ujjwal Joshi, Nina Filipczak, Muhammad Muzamil Khan, Sara Aly Attia, Vladimir Torchilin
Source: International Journal of Pharmaceutics - September 26, 2020 Category: Drugs & Pharmacology Source Type: research

Charge-reversible Lipid Derivative: A Novel Type of pH-responsive Lipid for Nanoparticle-mediated siRNA Delivery
Publication date: Available online 27 May 2020Source: International Journal of PharmaceuticsAuthor(s): Yusuke Hirai, Ryoko Saeki, Furan Song, Hiroyuki Koide, Naofumi Fukata, Koji Tomita, Noriyuki Maeda, Naoto Oku, Tomohiro Asai
Source: International Journal of Pharmaceutics - May 28, 2020 Category: Drugs & Pharmacology Source Type: research

In silico design and 3D printing of microfluidic chips for the preparation of size-controllable siRNA nanocomplexes
Publication date: Available online 4 May 2020Source: International Journal of PharmaceuticsAuthor(s): Yongquan Li, Johan Bøtker, Jukka Rantanen, Mingshi Yang, Adam Bohr
Source: International Journal of Pharmaceutics - May 4, 2020 Category: Drugs & Pharmacology Source Type: research

Codelivery of STAT3 siRNA and BV6 by carboxymethyl dextran trimethyl chitosan nanoparticles suppresses cancer cell progression
Publication date: Available online 30 March 2020Source: International Journal of PharmaceuticsAuthor(s): Afshin Nikkhoo, Narges Rostami, Shohreh Farhadi, Maryam Esmaily, Sadaf Moghadaszadeh Ardebili, Fatemeh Atyabi, Masoumeh Baghaei, Navideh Haghnavaz, Mehdi Yousefi, Mohammad Reza Aliparasti, Ghasem Ghalamfarsa, Hamed Mohammadi, Mozhdeh Sojoodi, Farhad Jadidi-Niaragh
Source: International Journal of Pharmaceutics - March 31, 2020 Category: Drugs & Pharmacology Source Type: research

Cholic acid-based mixed micelles as siRNA delivery agents for gene therapy
In this study, we demonstrate the use of lipids as co-surfactants for the preparation of mixed micelles to improve the siRNA delivery of cholic acid-based block copolymers. Poly(allyl glycidyl ether) (PAGE) and poly(ethylene glycol) (PEG) were polymerized on the surface of cholic acid to afford a star-shaped block copolymer with four arms (CA-PAGE-b-PEG)4. The allyl groups of PAGE were functionalized to bear primary or tertiary amines and folic acid was grafted onto the PEG chain end to increase cell uptake. (CA-PAGE-b-PEG)4 functionalized with either primary or tertiary amines show high siRNA complexation with close to 10...
Source: International Journal of Pharmaceutics - January 26, 2020 Category: Drugs & Pharmacology Source Type: research

Characteristics of unique endocytosis induced by weak current for cytoplasmic drug delivery
In this study, we evaluated the characteristics of WC-mediated endocytosis for application of the technology to cytoplasmic delivery of macromolecular medicines. WC induced significantly higher cellular uptake of exogenous DNA fragments compared to untreated cells; the amount increased in a time-dependent manner, indicating that endocytosis was induced after WC. Moreover, following WC treatment of cells in the presence of an antibody (MW: 150,000) with the lysosomotropic agent chloroquine, the antibody was able to bind to its intracellular target. Thus, high molecular weight protein medicines delivered by WC-mediated endoc...
Source: International Journal of Pharmaceutics - January 1, 2020 Category: Drugs & Pharmacology Source Type: research