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Source: Gene
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Total 132 results found since Jan 2013.
Simvastatin prevents BMP-2 driven cell migration and invasion by suppressing oncogenic DNMT1 expression in breast cancer cells
This study emphasized to decipher the molecular mechanism of endogenous regulation of DNMT1 expression for finding upstream signaling molecules. Cancer database analyses found an upregulated DNMT1 expression in most cancer types including breast cancer. Overexpression of DNMT1 showed an increased cell migration, invasion, and stemness potential whereas 5-azacytidine (DNMT1 inhibitor) and siRNA mediated knockdown of DNMT1 exhibited inhibition of such cancer activities in breast cancer MDA-MB-231 and MCF-7 cells. Infact, cancer database analyses further found a positive correlation of DNMT1 transcript with both cholesterol p...
Source: Gene - July 13, 2023 Category: Genetics & Stem Cells Authors: Pooja Yadav Shreetama Bandyopadhayaya Sneha Soni Sunil Saini Lokendra K Sharma Sandeep K Shrivastava Chandi C Manda Source Type: research
Effect of siRNA-mediated silencing of p53R2 gene on sensitivity of T-ALL cellsto Daunorubicin
CONCLUSION: The results of the present study showed that silencing of p53R2 using siRNA can significantly increase the antitumor effects of Daunorubicin on T-ALL cells. Therefore, p53R2 siRNA has the potential to be used as an adjuvant therapy in combination with Daunorubicin in T-ALL.PMID:37419428 | DOI:10.1016/j.gene.2023.147622
Source: Gene - July 7, 2023 Category: Genetics & Stem Cells Authors: Omid KianiGhalesardi Farhad Zaker Abbas Ghotaslou Hassan Boustani Mohammad Reza Rezvani Jafar Kiani Minoo Shahidi Source Type: research
Effects and regulatory pathway of proopinmelanocortin on feeding habit domestication in mandarin fish
Gene. 2023 Jun 17:147581. doi: 10.1016/j.gene.2023.147581. Online ahead of print.ABSTRACTProopiomelanocortin (POMC) is a hormone precursor, and has been reported to participate in domestication. However, its effects on feeding habit domestication in fish are poorly understood. Mandarin fish (Siniperca chuatsi) feeds solely on live prey fish since first-feeding. In the present study, the high expression of pomc in mandarin fish, both the pomc siRNA and MC4R inhibitor treatments increased the success rate of domestication from live prey fish to dead prey fish and food intake of dead prey fish, suggesting the role of pomc on ...
Source: Gene - June 19, 2023 Category: Genetics & Stem Cells Authors: Hai-Lin Lu Ling Li Yun-Liang Miao Hui Liang Jia-Ming Zou Jun-Jie You Xu-Fang Liang Shan He Source Type: research
A Novel Angiogenic Effect of PCSK9- Regulated Genes
CONCLUSION: PCSK9 might play an essential role in angiogenesis, unlike its typical role in lipid metabolism, and MMP9, Caspase3, LEFTY1, NODAL, and EGR1 may be involved in the regulation of angiogenesis as critical genes.PMID:36427678 | DOI:10.1016/j.gene.2022.147051
Source: Gene - November 25, 2022 Category: Genetics & Stem Cells Authors: Xiaopeng Zhan Li Jiang Lufeng Wang Jiwen Liu Sheng Kang Haibo Liu Li Lin Source Type: research
Gallic Acid has an inhibitory effect on skin squamous cell carcinoma and acts on the heat shock protein HSP90AB1
Gene. 2022 Nov 11:147041. doi: 10.1016/j.gene.2022.147041. Online ahead of print.ABSTRACTDifferences in the features of aggressiveness of non-melanoma skin cancer (NMSC) subtypes, between basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are relevant characteristics. Comparing the characteristics between NMSC subtypes might help identify molecules associated with cancer metastasis and invasion. Considering these facts, the current study aimed to identify a molecular target for inhibiting skin cancer metastasis and invasion. Proteomic analysis suggested that heat shock protein 90 kDa, alpha, class B member 1 (HSP...
Source: Gene - November 14, 2022 Category: Genetics & Stem Cells Authors: Sabrina Ferreira de Jesus Marcela Gon çalves de Souza Lorena Dos Reis Pereira Queiroz Daniela Paola Santos de Paula Angeliny Tamiarana Lima Tabosa Wislene Sarajane Moreira Alves Luiz Henrique da Silveira Andr é Teixeira da Silva Ferreira Ozires Jos é D Source Type: research
The lysine methyltransferases SET and MYND domain containing 2 (Smyd2) and Enhancer of Zeste 2 (Ezh2) co-regulate osteoblast proliferation and mineralization
Gene. 2022 Sep 30:146928. doi: 10.1016/j.gene.2022.146928. Online ahead of print.ABSTRACTBone formation is controlled by histone modifying enzymes that regulate post-translational modifications on nucleosomal histone proteins and control accessibility of transcription factors to gene promoters required for osteogenesis. Enhancer of Zeste homolog 2 (EZH2/Ezh2), a histone H3 lysine 27 (H3K27) methyl transferase, is a suppressor of osteoblast differentiation. Ezh2 is regulated by SET and MYND domain-containing protein 2 (SMYD2/Smyd2), a lysine methyltransferase that modifies both histone and non-histone proteins. Here, we exa...
Source: Gene - October 3, 2022 Category: Genetics & Stem Cells Authors: Parisa Dashti Jeroen van de Peppel Roman Thaler Christopher R Paradise Gary S Stein Martin A Montecino Johannes P T M van Leeuwen Bram J van der Eerden Amel Dudakovic Andre J van Wijnen Source Type: research
Survivin; a novel therapeutic target that correlates with survival of autoreactive T lymphocytes obtained from patients with Ankylosing Spondylitis
Gene. 2022 Aug 19:146829. doi: 10.1016/j.gene.2022.146829. Online ahead of print.ABSTRACTAnkylosing spondylitis (AS) is progressive immune-mediated arthritis. Persistent autoreactivity of T cells with an up-regulated Survivin expression is strongly implicated in AS immunopathogenesis. Besides, Survivin can inhibit proapoptotic caspase 9 activations. Moreover, microRNAs are small non-coding RNAs that are dysregulated in various diseases, in which their altered expression could modulate Survivin expression. The primary goal of this study was to assess the role of Survivin and its-targeting microRNAs in the immunopathogenesis...
Source: Gene - August 22, 2022 Category: Genetics & Stem Cells Authors: Navid Shomali Behzad Baradaran Amin Daei Sorkhabi Aila Sarkesh Mohammad Saeed Kahrizi Foad Tosan Ata Mahmoodpoor Amirhossein Mardi Hamed Mohammadi Ali Hasanzadeh Hossein Saeedi Mehrzad Hajialilo Maryam Hemmatzadeh Faroogh Marofi Siamak Sandoghchian Shotor Source Type: research
Silencing effects of FOXD1 inhibit metastatic potentials of the PCa via N-cadherin - Wnt/ β-catenin crosstalk
Gene. 2022 Jun 20:146680. doi: 10.1016/j.gene.2022.146680. Online ahead of print.ABSTRACTThe elucidation of the mechanisms controlling the metastatic processes is important for the development of new treatment methods to prevent the progression of localized disease to metastasis. Forkhead box D1 (FOXD1) is a member of the FOX transcription factor family and has been reported to play an important role in the development and progression of various cancers. However, its role in prostate cancer (PCa) remains only partially understood. Therefore, we aimed to explore the effects on the associated regulatory signal pathway of FOX...
Source: Gene - June 23, 2022 Category: Genetics & Stem Cells Authors: Cigdem Donmez Ece Konac Source Type: research
