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Total 6 results found since Jan 2013.
Ability to Suppress TGF- β-Activated Myofibroblast Differentiation Distinguishes the Anti-pulmonary Fibrosis Efficacy of Two Danshen-Containing Chinese Herbal Medicine Prescriptions
Conclusion: This study suggests that a clinically efficacious cardiovascular Chinese herbal medicine (DLP) can be successfully repurposed to treat a lung disease in pulmonary fibrosis guided by TCM theory. Our comparative study between DLP and DHP demonstrated a critical requirement of suppressing both pro-inflammatory and pro-fibrotic pathways for the treatment of pulmonary fibrosis, supporting that a multi-component prescription capable of “removing both phlegm and blood stasis” will better achieve co-protection of heart and lung in PHD.
Introduction
Idiopathic pulmonary fibrosis (IPF) is a chronic ...
Source: Frontiers in Pharmacology - April 23, 2019 Category: Drugs & Pharmacology Source Type: research
Regulation of Chromatin Assembly and Cell Transformation by Formaldehyde Exposure in Human Cells
Conclusions:
We propose that the inhibition of chromatin assembly represents a novel mechanism of cell transformation induced by the environmental and occupational chemical carcinogen FA. https://doi.org/10.1289/EHP1275
Received: 25 October 2016
Revised: 19 May 2017
Accepted: 23 May 2017
Published: 21 September 2017
Address correspondence to C. Jin, Dept. of Environmental Medicine, New York University School of Medicine, 57 Old Forge Rd., Tuxedo Park, NY 10987 USA. Telephone: (845) 731-3602. Email: Chunyuan.jin@nyumc.org
*Current affiliation: Medical School of Nanjing University, Nanjing, China.
†Current affiliatio...
Source: EHP Research - September 21, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research
GSE73422 Expression data from human osteosarcoma cells treated with CDK11 siRNA
Contributors : Yong Feng ; Zhenfeng DuanSeries Type : Expression profiling by arrayOrganism : Homo sapiensThe U-2OS and KHOS osteosarcoma cell lines where seeded onto the 100mm cell culture plate, then treated with CDK11 siRNA (40nM) or nonspecificsiRNA (40nM). Change with regular medium 24 hour later. Total RNA was collected from these cells using TRIzol® Reagent (GIBCO Grand Island, NY) according to the manufacturer’s instructions. To account for and eliminate biologic noise, RNA was isolated from three distinct flasks of each cell line and pooled together. RNA quality was determined via ethidium bromide staining foll...
Source: GEO: Gene Expression Omnibus - October 7, 2015 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
Drug Repurposing Screen Identifies Foxo1-Dependent Angiopoietin-2 Regulation in Sepsis*
Conclusions: 3-hydroxy-3-methyl-glutaryl-CoA reductase inhibitors may operate through a novel Foxo1-angiopoietin-2 mechanism to suppress de novo production of angiopoietin-2 and thereby ameliorate manifestations of sepsis. Given angiopoietin-2’s dual role as a biomarker and candidate disease mediator, early serum angiopoietin-2 measurement may serve as a stratification tool for future trials of drugs targeting vascular leakage.
Source: Critical Care Medicine - June 17, 2015 Category: Emergency Medicine Tags: Online Laboratory Investigations Source Type: research
Abstract SY43-03: Screening for triple negative breast cancer vulnerabilities
There is no targeted therapy for triple negative breast cancers (TNBC), which have the worst prognosis of human breast cancers. TNBCs are prone to relapse and metastasize after cytotoxic drug treatment. This group of cancers, defined by low or absent expression of estrogen, progesterone and Her2 receptors, are heterogeneous in genetic, epigenetic and phenotypic features, making it difficult to identify specific drug targets suitable for this group of cancers as a whole. About half or more of TNBCs have an epithelial phenotype (classified based on gene expression profiling as basal-like or basal-A) and a large minority of t...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Petrocca, F., Altschuler, G., Tan, S. M., Mendillo, M. L., Yan, H., Jerry, D. J., Kung, A. L., Hide, W., Ince, T. A., Lieberman, J. Tags: Experimental and Molecular Therapeutics Source Type: research
Early animal research into blocking breast cancer
"'An injection that prevents breast cancer is being developed by scientists," is the news on the Mail Online website.
This news seems a heartening way to start the year, but a caveat is that the research is in the very early stages – as yet only tested in mice.
The researchers were interested in a type of breast cancer known as ductal carcinoma in situ (DCIS).
In DCIS the cancerous cells are contained within the ducts in the breast, and not spread to other breast tissue. The problem with DCIS is that it is currently impossible to predict whether the cancer will remain inside the duct (so will not require tr...
Source: NHS News Feed - January 2, 2014 Category: Consumer Health News Tags: Cancer Source Type: news
