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Approaches to Identifying Synthetic Lethal Interactions in Cancer.
Authors: Thompson JM, Nguyen QH, Singh M, Razorenova OV Abstract Targeting synthetic lethal interactions is a promising new therapeutic approach to exploit specific changes that occur within cancer cells. Multiple approaches to investigate these interactions have been developed and successfully implemented, including chemical, siRNA, shRNA, and CRISPR library screens. Genome-wide computational approaches, such as DAISY, also have been successful in predicting synthetic lethal interactions from both cancer cell lines and patient samples. Each approach has its advantages and disadvantages that need to be considered d...
Source: The Yale Journal of Biology and Medicine - June 2, 2015 Category: Universities & Medical Training Tags: Yale J Biol Med Source Type: research