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Vitamin D inhibits osteosarcoma by reprogramming nonsense-mediated RNA decay and SNAI2-mediated epithelial-to-mesenchymal transition
In this study, we assessed the impact of vitamin D and its receptor (VDR) on NMD-ROS-EMT signaling in in vitro and in vivo osteosarcoma animal models. Initiation of VDR signaling facilitated the enrichment of EMT pathway genes, after which 1,25(OH)2D, the active vitamin D derivative, inhibited the EMT pathway in osteosarcoma subtypes. The ligand-bound VDR directly downregulated the EMT inducer SNAI2, differentiating highly metastatic from low metastatic subtypes and 1,25(OH)2D sensitivity. Moreover, epigenome-wide motif and putative target gene analysis revealed the VDR’s integration with NMD tumorigenic and immunogenic ...
Source: Frontiers in Oncology - May 9, 2023 Category: Cancer & Oncology Source Type: research

Activation of Vitamin D/VDR Signaling Reverses Gemcitabine Resistance of Pancreatic Cancer Cells Through Inhibition of MUC1 Expression
ConclusionThese findings demonstrate a previously unidentified vitamin D/VDR-MUC1 signaling axis involved in the regulation of gemcitabine resistance in PDA and suggests that combinational therapies that include targeted activation of vitamin D/VDR signaling may improve the outcomes of patients with PDA.
Source: Digestive Diseases and Sciences - April 18, 2023 Category: Gastroenterology Source Type: research

Calcipotriol inhibits α‐synuclein aggregation in SH‐SY5Y neuroblastoma cells by a Calbindin‐D28K‐dependent mechanism
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - February 5, 2017 Category: Neuroscience Authors: Alexandre N. Rcom ‐H'cheo‐Gauthier, Adrian C. B. Meedeniya, Dean L. Pountney Tags: Original Article Source Type: research

Zinc finger protein A20 is involved in the antipsoriatic effect of calcipotriol
ConclusionsCalcipotriol exhibits its antipsoriatic function through suppressing A20 expression and stabilizing negative regulators of the NF‐κB pathway.
Source: British Journal of Dermatology - May 13, 2016 Category: Dermatology Authors: X. Liu, Y. Liu, M. Xu, J. Li, X. Teng, H. Cheng, Y. Xia Tags: Translational Research Source Type: research

Zinc finger protein A20 is involved in the anti‐psoriatic effect of calcipotriol
ConclusionsCalcipotriol exhibits anti‐psoriatic function through suppressing A20 expression and stabilizing negative regulators of NF‐κB pathway.This article is protected by copyright. All rights reserved.
Source: British Journal of Dermatology - February 15, 2016 Category: Dermatology Authors: X. Liu, Y. Liu, M. Xu, J. Li, X. Teng, H. Cheng, Y. Xia Tags: Original Article Source Type: research

Zinc finger protein A20 is involved in the anti-psoriatic effect of calcipotriol.
CONCLUSIONS: Calcipotriol exhibits anti-psoriatic function through suppressing A20 expression and stabilizing negative regulators of NF-κB pathway. This article is protected by copyright. All rights reserved. PMID: 26875609 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - February 15, 2016 Category: Dermatology Authors: Liu X, Liu Y, Xu M, Li J, Teng X, Cheng H, Xia Y Tags: Br J Dermatol Source Type: research