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Drug: Sevoflurane

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Total 39 results found since Jan 2013.

Neuroprotective effect of dexmedetomidine pretreatment on sevoflurane-initiated neurotoxicity via the miR-204-5p/SOX4 axis
CONCLUSION: Dex pretreatment decreased miR-204-5p expression levels and upregulated SOX4 expression levels, palliating Sev-initiated neurotoxicity.PMID:37259215 | DOI:10.2174/0929866530666230530164913
Source: Protein and Peptide Letters - June 1, 2023 Category: Biochemistry Authors: Run Wang Pengfei Liu Fan Li Hui Qiao Source Type: research

γ-Aminobutyric Acid-Ergic Development Contributes to the Enhancement of Electroencephalogram Slow-Delta Oscillations Under Volatile Anesthesia in Neonatal Rats
CONCLUSIONS: Enhancement of cortical EEG slow-delta oscillations by volatile anesthetics may require mature GABAergic inhibitory transmission during neonatal development.PMID:36753442 | DOI:10.1213/ANE.0000000000006396
Source: Anesthesia and Analgesia - February 8, 2023 Category: Anesthesiology Authors: Mingyue Zhang Yali Chen Ting Xu Jingyao Jiang Donghang Zhang Han Huang Charles D Kurth Ian Yuan Rurong Wang Jin Liu Tao Zhu Cheng Zhou Source Type: research

4.8% sevoflurane induces activation of autophagy in human neuroblastoma SH-SY5Y cells by the AMPK/mTOR signaling pathway
Neurotoxicology. 2022 Apr 23:S0161-813X(22)00056-0. doi: 10.1016/j.neuro.2022.04.008. Online ahead of print.ABSTRACTProlonged sevoflurane exposure leads to neurotoxicity. Autophagy plays an important role in promoting cell survival in different conditions. However, the role and mechanism of autophagy in sevoflurane-induced neurotoxicity were not fully elucidated. We attempted to indicate whether sevoflurane could activate the AMP-activated protein kinase (AMPK)/mechanistic target of rapamycin (mTOR)-mediated autophagy to attenuate anesthetics-induced neuronal injury in this study. Sevoflurane treatment significantly decrea...
Source: Neurotoxicology - April 26, 2022 Category: Neurology Authors: Jingjing Lv Hao Cheng Weidong Yao Can Liu Yongquan Chen Xiaoju Jin Zeyong Yang Yuanhai Li Source Type: research

Sevoflurane Induces Ferroptosis of Glioma Cells Through Activating the ATF4-CHAC1 Pathway
ConclusionsIn summary, this study suggested that Sev exposure-induced ferroptosis by the ATF4-CHAC1 pathway in glioma cells.
Source: Frontiers in Oncology - March 17, 2022 Category: Cancer & Oncology Source Type: research

Sevoflurane preconditioning promotes mesenchymal stem cells to relieve myocardial ischemia/reperfusion injury via TRPC6-induced angiogenesis
CONCLUSION: The current findings reveal that sevoflurane preconditioned MSCs boost angiogenesis in HUVECs subjected to H/R insult and attenuate myocardial I/R injury, which may be mediated by TRPC6 up-regulated HIF-1α, CXCR4 and VEGF.PMID:34809715 | DOI:10.1186/s13287-021-02649-3
Source: Cell Research - November 23, 2021 Category: Cytology Authors: Jinting Yang Lihui Tang Fengjiang Zhang Tingting Yang Ting Lu Kai Sun Na Sun Jinxuan Ren Min Yan Source Type: research

Sevoflurane postconditioning reduces hypoxia/reoxygenation injury in cardiomyocytes via up-regulating heat shock proteins 70
In conclusion, this study demonstrated that SPostC reduced the HR injury of cardiomyocytes by inducing HSP70 expression.PMID:34226409 | DOI:10.4014/jmb.2103.03040
Source: Journal of Microbiology and Biotechnology - July 6, 2021 Category: Biotechnology Authors: Jun Zhang Haiyan Wang Xizhi Sun Source Type: research