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Activation of voltage-gated sodium current and inhibition of erg-mediated potassium current caused by telmisartan, an antagonist of angiotensin II type-1 receptor, in HL-1 atrial cardiomyocytes.
This article is protected by copyright. All rights reserved. PMID: 29617054 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Pharmacology and Physiology - April 4, 2018 Category: Drugs & Pharmacology Authors: Chang WT, Wu SN Tags: Clin Exp Pharmacol Physiol Source Type: research

Effect of Small Interference RNA on the Acetylcholine-Sensitive Potassium Channel in H9c2 Cells.
CONCLUSION: siRNA could effectively inhibit the IK(ACh) channel and is a potential therapy for atrial fibrillation. PMID: 25696012 [PubMed - as supplied by publisher]
Source: Annals of Clinical and Laboratory Science - January 1, 2015 Category: Laboratory Medicine Authors: He F, Zhao J, Li L, Guo R Tags: Ann Clin Lab Sci Source Type: research

Altered Surfactant Homeostasis and Alveolar Epithelial Cell Stress in Amiodarone-Induced Lung Fibrosis
Amiodarone (AD) is a highly efficient antiarrhythmic drug with potentially serious side effects. Severe pulmonary toxicity is reported in patients receiving AD even at low doses and may cause interstitial pneumonia as well as lung fibrosis. Apoptosis of alveolar epithelial type II cells (AECII) has been suggested to play an important role in this disease. In the current study, we aimed to establish a murine model of AD-induced lung fibrosis and analyze surfactant homeostasis, lysosomal, and endoplasmic reticulum (ER) stress in this model. AD/vehicle was instilled intratracheally into C57BL/6 mice, which were sacrificed on ...
Source: Toxicological Sciences - November 10, 2014 Category: Toxicology Authors: Mahavadi, P., Henneke, I., Ruppert, C., Knudsen, L., Venkatesan, S., Liebisch, G., Chambers, R. C., Ochs, M., Schmitz, G., Vancheri, C., Seeger, W., Korfei, M., Guenther, A. Tags: Inhalation and Respiratory Source Type: research