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L-theanine induces skeletal muscle fiber type transformation by activation of prox1/CaN signaling pathway in C2C12 myotubes
Biol Chem. 2022 Jul 18. doi: 10.1515/hsz-2022-0165. Online ahead of print.ABSTRACTThe aim of this study was to investigate the effect and mechanism of L-theanine (LT) on muscle fiber type transformation in C2C12 myotubes. Our data showed that LT exhibited significantly higher slow oxidative muscle fiber expression and lower glycolytic fibers expression. In addition, LT significantly increased the activities of malate dehydrogenase (MDH) and succinic dehydrogenase (SDH), and decreased lactate dehydrogenase (LDH) activity, the calcineurin (CaN) activity and the protein expressions of nuclear factor of activated T cell 1 (NFA...
Source: Biological Chemistry - July 19, 2022 Category: Chemistry Authors: Xiaoling Chen Man Zhang Gang Jia Hua Zhao Guangmang Liu Zhiqing Huang Source Type: research
