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CCT6A promotes esophageal squamous cell carcinoma cell proliferation, invasion and epithelial-mesenchymal transition by activating TGF- β/Smad/c-Myc pathway
ConclusionCCT6A facilitates ESCC malignant activities by activating the TGF- β/Smad/c-Myc pathway, which sheds light on the identification of a possible therapeutic target in the management of ESCC.
Source: Irish Journal of Medical Science - April 5, 2023 Category: General Medicine Source Type: research

A novel role for CRIM1 in the corneal response to UV and pterygium development.
In this study, a Northern Irish family affected by pterygium but reporting little direct exposure to UV was identified carrying a missense variant in CRIM1 NM_016441.2: c.1235 A > C (H412P) through whole-exome sequencing and subsequent analysis. CRIM1 is expressed in the developing eye, adult cornea and conjunctiva, having a role in cell differentiation and migration but also in angiogenesis, all processes involved in pterygium formation. We demonstrate elevated CRIM1 expression in pterygium tissue from additional individual Northern Irish patients compared to unaffected conjunctival controls. UV irradiation of HCE-...
Source: Experimental Eye Research - October 23, 2018 Category: Opthalmology Authors: Maurizi E, Schiroli D, Atkinson SD, Mairs L, Courtney DG, O'Hagan B, McGilligan VE, Pagnamenta AT, Taylor JC, Vasquez JJD, Illanes-Velarde DE, Goldsmith D, Gouws P, Moore JE, Nesbit MA, Moore CBT Tags: Exp Eye Res Source Type: research

Long non-coding RNA TRPM2-AS as a potential biomarker for hepatocellular carcinoma
ConclusionLong non-coding RNA TRPM2-AS is upregulated in HCC and represents a new biomarker for HCC and the inhibition of TRPM2-AS promotes apoptosis in HCC cells in vitro.
Source: Irish Journal of Medical Science - July 25, 2018 Category: General Medicine Source Type: research