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Total 16 results found since Jan 2013.
Melatonin MT < sub > 2 < /sub > receptor is expressed and potentiates contraction in human airway smooth muscle
Am J Physiol Lung Cell Mol Physiol. 2021 Oct 6. doi: 10.1152/ajplung.00273.2021. Online ahead of print.ABSTRACTNocturnal asthma is characterized by heightened bronchial reactivity at night, and plasma melatonin concentrations are higher in patients with nocturnal asthma symptoms. Numerous physiological effects of melatonin are mediated via its specific G protein-coupled receptors (GPCRs) named the MT1 receptor which couples to both Gq and Gi proteins, and the MT2 receptor which couples to Gi. We investigated whether melatonin receptors are expressed on airway smooth muscle, whether they regulate intracellular cyclic AMP (c...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - October 6, 2021 Category: Cytology Authors: Haruka Sasaki Yi Zhang Charles W Emala Kentaro Mizuta Source Type: research
RSV Promotes Epithelial Neuroendocrine Phenotype Differentiation through NODAL Signaling Pathway
CONCLUSION: RSV promotes epithelial neuroendocrine phenotypes through the NODAL signaling pathway.PMID:34541002 | PMC:PMC8445725 | DOI:10.1155/2021/9956078
Source: Biomed Res - September 20, 2021 Category: Research Authors: Dan Liu Zhongxiang Tang Kezi Qiu Ousman Bajinka Lili Wang Ling Qin Yurong Tan Source Type: research
Stem Cell Factor-Inducible MITF-M Expression in Therapeutics for Acquired Skin Hyperpigmentation
Conclusion: We propose the targeting of SCF/KIT-inducible MITF-M expression as a strategy in the therapeutics for acquired pigmentary disorders.
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Cheong-Yong Yun, Eunmiri Roh, Song-Hee Kim, Jinhe Han, Jiyeon Lee, Da-Eun Jung, Ga Hyeon Kim, Sang-Hun Jung, Won-Jea Cho, Sang-Bae Han, Youngsoo Kim Tags: Research Paper Source Type: research
β-Arrestin2 regulates the rapid component of delayed rectifier K+ currents and cardiac action potential of guinea pig cardiomyocytes after adrenergic stimulation.
This study investigated the role of β-arrestin2 in the regulation of cardiac hERG/IKr potassium channel and AP during chronic adrenergic stimulation. Single left ventricular myocytes were isolated from guinea pig heart, and were transfected with adenovirus encoding β-arrestin2, or β-arrestin2 siRNA or an empty adenovirus. Cell cultures containing 10 nM isoproterenol, 1 nM phenylephrine or vehicle alone (control medium) were electro-physiologically examined after 48 h of incubation. Action potential duration at 50 and 90 % of repolarization (APD50 and APD90) were measured using whole-cell patch-clamp recording. Sustained...
Source: Cellular and Molecular Biology - December 29, 2019 Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research
