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Paternal Expressed Gene 10 (PEG10) is decreased in early-onset preeclampsia
CONCLUSIONS: Placental PEG10 is reduced in patients with early-onset preeclampsia. In vitro studies suggest that hypoxia and inflammation may contribute to PEG10 downregulation. Reduced PEG10 alters canonical TGF-[Formula: see text] signalling, and thus may be involved in trophoblast dysfunction associated with this pathway.PMID:37464405 | PMC:PMC10355026 | DOI:10.1186/s12958-023-01116-3
Source: Reproductive Biology - July 18, 2023 Category: Reproduction Medicine Authors: Lydia Baird Ping Cannon Manju Kandel Tuong-Vi Nguyen Anna Nguyen Georgia Wong C íara Murphy Fiona C Brownfoot Elif Kadife Natalie J Hannan Stephen Tong Lucy A Bartho Tu'uhevaha J Kaitu'u-Lino Source Type: research

Small Interfering RNA (siRNA) Transfection in Epiblast Stem Cells
Methods Mol Biol. 2022;2490:47-55. doi: 10.1007/978-1-0716-2281-0_5.ABSTRACTLipid-based transfection of siRNA is a technique routinely used to investigate gene function in experiments using mammalian cells cultured in vitro. Due to innate differences in cellular characteristics, the efficiency of lipid-based transfection is variable across cell types. Pluripotent cells which exist in a "primed" state such as human embryonic stem cells (hESCs) and mouse epiblast stem cells (mEpiSCs) are notorious for being refractory to lipid-based transfection systems. Herein we describe a forward transfection protocol which we routinely u...
Source: Mol Biol Cell - April 29, 2022 Category: Molecular Biology Authors: Georgia R Kafer Source Type: research

SOCS and Herpesviruses, With Emphasis on Cytomegalovirus Retinitis
Christine I. Alston1,2 and Richard D. Dix1,2* 1Department of Biology, Viral Immunology Center, Georgia State University, Atlanta, GA, United States 2Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA, United States Suppressor of cytokine signaling (SOCS) proteins provide selective negative feedback to prevent pathogeneses caused by overstimulation of the immune system. Of the eight known SOCS proteins, SOCS1 and SOCS3 are the best studied, and systemic deletion of either gene causes early lethality in mice. Many viruses, including herpesviruses such as herpes simplex virus and cytomega...
Source: Frontiers in Immunology - April 10, 2019 Category: Allergy & Immunology Source Type: research