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A new Alzheimer's disease cell model using B cells to induce beta amyloid plaque formation and increase TNF alpha expression.
Abstract Different cell models have been developed for the study of Alzheimer's disease (AD) pathways. The neuronal dysfunction and cell death mechanisms that are commonly found in this disease are due to the production of high levels of cytokines and the formation of amyloid plaques. In the cell model introduced in the present study, the production of these two important factors is induced by using B cells from an AD patient. The B cells of an Alzheimer's patient and a normal control were immortalized by using EBV (Epstein-Barr virus) to produce a lymphoblastoid cell line (LCL). The amount of TNF alpha cytokine w...
Source: International Immunopharmacology - April 10, 2018 Category: Allergy & Immunology Authors: Dezfulian M Tags: Int Immunopharmacol Source Type: research