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Cancer: Soft Tissue Sarcoma

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Total 24 results found since Jan 2013.

Abstracts of Presentations at the Association of Clinical Scientists 143 < sup > rd < /sup > Meeting Louisville, KY May 11-14,2022
Conclusion: These assays are suitable for routine diagnostic. The UltraFast NextGenPCR is the fastest with average time (30mins), followed by Agilent (2 hrs) and MassArray (6hrs). Upon completion of this activity, participants should be able to examine, measure and compare results from different assays for SARS detection, evaluate and diagnose accurately, as well as being able to plan, organize and recommend a diagnostic procedure for diagnostic laboratory. Key words: SARS-CoV-2, RNA extraction, RT-PCR, limit of detection, quantification cycle, COVID-19, in vitro diagnostic tests, Agilent, Massarray, Ultrafast. [20] From t...
Source: Annals of Clinical and Laboratory Science - July 1, 2022 Category: Laboratory Medicine Source Type: research

Genes, Vol. 12, Pages 1373: High Frequency of Tumor Propagating Cells in Fusion-Positive Rhabdomyosarcoma
In this study we investigated the expression of key stem cell markers, developed a sphere assay, and investigated the seven most common FPRMS cell lines for subpopulations of tumor propagating cancer stem-like cells, also called cancer stem cells (CSCs). Moreover, loss- and gain-of-functions of the stem cell genes SOX2, OCT4, and NANOG were investigated in the same cells. Single-cell clonal analysis was performed in vitro as well as in vivo. We found that no stable CSC subpopulation could be enriched in FPRMS. Unlike depletion of PAX3-FOXO1, neither overexpression nor siRNA-mediated downregulation of SOX2, OCT4, and NANOG ...
Source: Genes - August 31, 2021 Category: Genetics & Stem Cells Authors: Melanie Generali Sampoorna Satheesha Peter K. Bode Debora Wanner Beat W. Sch äfer Elisa A. Casanova Tags: Article Source Type: research

Identification of Somatic Genetic Alterations Using Whole-Exome Sequencing of Uterine Leiomyosarcoma Tumors
ConclusionsExome sequencing revealed mutational heterogeneity of uLMS. The SHARPIN gene was amplified in uLMS and could be a candidate oncogene.
Source: Frontiers in Oncology - June 11, 2021 Category: Cancer & Oncology Source Type: research

GSE156344 A lncRNA HAR1B has a potential as a predictive marker for pazopanib therapy in patients with sarcoma
Contributors : Hideharu Yamada ; Masanobu Takahashi ; Munenori Watanuki ; Mika Watanabe ; Sakura Hiraide ; Ken Saijo ; Keigo Komine ; Chikashi IshiokaSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiensBone and soft tissue sarcomas are rare and highly heterogeneous mesenchymal malignancies. Their rarity makes it difficult to acquire clinical data of patients with specific histological subtypes of sarcoma from large clinical trials. The diagnoses and treatment of sarcomas need to be further developed. We show that a long non-coding RNA (lncRNA) HAR1B may serve as predictive biomarkers for pazopanib treatme...
Source: GEO: Gene Expression Omnibus - April 28, 2021 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by array Homo sapiens Source Type: research

Cancers, Vol. 12, Pages 2556: Impact of Wnt/ β-Catenin Inhibition on Cell Proliferation through CDC25A Downregulation in Soft Tissue Sarcomas
Cancers, Vol. 12, Pages 2556: Impact of Wnt/β-Catenin Inhibition on Cell Proliferation through CDC25A Downregulation in Soft Tissue Sarcomas Cancers doi: 10.3390/cancers12092556 Authors: Esther Martinez-Font Marina Pérez-Capó Rafael Ramos Irene Felipe Carmen Garcías Pablo Luna Josefa Terrasa Javier Martín-Broto Oliver Vögler Regina Alemany Antònia Obrador-Hevia The Wnt signaling pathway is an important cellular mechanism for regulating differentiation processes as well as cell cycle events, and different inhibitors of this pathway, for example, PRI-724, are showing promising results in cl...
Source: Cancers - September 7, 2020 Category: Cancer & Oncology Authors: Esther Martinez-Font Marina P érez-Capó Rafael Ramos Irene Felipe Carmen Garc ías Pablo Luna Josefa Terrasa Javier Mart ín-Broto Oliver V ögler Regina Alemany Ant ònia Obrador-Hevia Tags: Article Source Type: research

High Expression of DEPDC1 Promotes Malignant Phenotypes of Breast Cancer Cells and Predicts Poor Prognosis in Patients With Breast Cancer
In this study, the immunohistochemistry results demonstrated that DEPDC1 was high-expressed in breast cancer tissues compared with the paired adjacent normal breast tissues, and its tendency at protein level was consistent with mRNA level from TCGA data. Moreover, DEPDC1 mRNA level revealed the strongest association with poor prognosis and development in breast cancer. In vitro assays showed that DEPDC1 overexpression resulted in significant promotion of proliferation by regulating cell cycle in MCF-7 cells, whilst an opposite effect was found in the MDA-MB-231 cells with DEPDC1 deletion. Notably, further investigation ind...
Source: Frontiers in Oncology - April 11, 2019 Category: Cancer & Oncology Source Type: research